Neoplastic Transformation in Human Cell Culture: Mechanisms of Carcinogenesis

Front Matter....Pages i-xxxi
Front Matter....Pages 1-1
Comparison of Human Versus Rodent Cell Transformation: Importance of Cell Aging....Pages 3-13
Deficient DNA Repair, an Early Step in Neoplastic Transformation of Human Cells in Culture....Pages 15-23
Use of Immortalized Human Keratinocytes for the Study of Squamous Differentiation and Mutagenesis....Pages 25-34
Studies of Mutagen-Activated Genes which Confer Anchorage-Independence: the c-sis Gene as a Model....Pages 35-46
Cytoskeletal Changes in Human Transformed Cells: Studies on HOS Cells....Pages 47-56
Polyamine Metabolism in Human Epidermal Keratinocytes Transformed with AD12-SV40, HPV16-DNA and K- ras Oncogene....Pages 57-64
Front Matter....Pages 65-65
Transformation of Human Diploid Fibroblasts by Radiation and Oncogenes....Pages 67-79
Ionizing Radiation-Mediated Protein Kinase C Activation and Gene Expression....Pages 81-92
Detection of Transforming Genes from Radiation Transformed Human Epidermal Keratinocytes by a Tumorigenicity Assay....Pages 93-101
Neoplastic Transformation of Human Epithelial Cells by Ionizing Radiation....Pages 103-111
Effects of Ionizing Radiation on Human Papillomavirus Immortalized Human Bronchial Epithelial Cells....Pages 113-117
Biochemical Purification of a CSF-1 like Molecule Released during Malignant Transformation of IL-3 Dependent Hematopoietic Progenitor cell lines Cocultivated with Gamma Irradiated Clonal Marrow Stromal cell lines....Pages 119-123
An Inherited P53 Point Mutation in a Cancer Prone Family with Li-Fraumeni Syndrome....Pages 125-134
p53, a Direct Target of Mutational Activation by Chemical Carcinogens?....Pages 135-139
Front Matter....Pages 141-141
The HIV tat Gene Induces Epidermal Hyperplasia in vivo and Transforms Keratinocytes in vitro ....Pages 143-152
Immortalization and Tumorigenic Transformation of Normal Human Cervical Epithelial Cells Transfected with Human Papillomavirus DNAs....Pages 153-161
Using the Papillomavirus E6/E7 Genes to Generate Well-Differentiated Epithelial Cell Lines....Pages 163-167
Tumor Progression in Breast Cancer....Pages 169-178
Growth Regulation of HPV-Positive Keratinocytes by TGF- β l....Pages 179-189
Cell Growth Transformation by Epstein Barr Virus....Pages 191-201
Front Matter....Pages 141-141
Isolation and Characterization of a Transformation-Associated Gene from Human Nasopharyngeal Carcinoma Cells....Pages 203-212
Molecular Pathogenesis of Lung Cancer....Pages 213-221
Molecular Control of Expression of Plasticity of Tumorigenic/Metastatic Phenotypes....Pages 223-232
Front Matter....Pages 233-233
Altered Regulation of Growth and Differentiation at Different Stages of Transformation of Human Skin Keratinocytes....Pages 235-250
Neoplastic Transformation and Suppression of Transformation of Human Bronchial Epithelial Cells in vitro ....Pages 251-258
An in vitro Human Mammary Epithelial Model System for Studies of Differentiation and Carcinogenesis....Pages 259-267
Transformation in vitro of Human Uroepithelial Cells....Pages 269-280
Multiple Steps in the in vitro Immortalisation and Neoplastic Conversion of Human Colonic Epithelial Cells....Pages 281-290
A Human Renal Epithelial Multistep Model of in vitro Carcinogenesis....Pages 291-296
Immortalization and Oncogene Transformation of Human Esophageal Epithelial Cells....Pages 297-305
A Non-Tumorigenic Human Liver Epithelial Cell Culture Model for Chemical and Biological Carcinogenesis Investigations....Pages 307-321
Establishment and Characterization of SV40 T-Antigen Immortalized Human Liver Cells....Pages 323-332
Transformation of Human Tracheal Gland Epithelial Cells in vitro ....Pages 333-341
Stable Expression of SV40 Large T-Antigen Gene in Primary Human Schwann Cells....Pages 343-346
Malignant Transformation of Human Fibroblasts in vitro ....Pages 347-357
Mitogen-independence and Autocrine Growth Factor Secretion Displayed by Human Mesothelioma Cells and Oncogene-Transfected Mesothelial Cells....Pages 359-366
Structure and Growth Regulation in Normal, Transformed and Malignant Human Endometrial Cell Cultures....Pages 367-376
Construction of a Unidirectional cDNA Library from a Radioresistant Laryngeal Squamous Cell Carcinoma Cell Line in an Epstein Barr Virus Shuttle Vector....Pages 377-386
Back Matter....Pages 387-396