National Institute of Allergy and Infectious Diseases, NIH: Volume 3: Intramural Research

Front Matter....Pages i-xix
Front Matter....Pages 1-1
The Evolution of Gammaretrovirus Restriction Factors in the Mouse....Pages 3-11
Herpesvirus Research at the National Institute of Allergy and Infectious Diseases: Thirty Years of Progress....Pages 13-25
Why Study Mouse Retroviruses?....Pages 27-30
Functions of the Rotavirus RNA Polymerase in Virus Replication....Pages 31-40
Human T-Cell Leukemia Virus Type 1, Cellular Transformation, and Adult T-Cell Leukemia....Pages 41-49
Front Matter....Pages 51-51
Roles for Chemokine Receptors in HIV Pathogenesis....Pages 53-57
HIV-1 Accessory Proteins: Crucial Elements for Virus-Host Interactions....Pages 59-71
Front Matter....Pages 73-73
Exploring the Cause of Human Q Fever: Recent Advances in Coxiella burnetii Research....Pages 75-85
Plague in the 21st Century: Global Public Health Challenges and Goals....Pages 87-94
Molecular Biology of Staphylococcal Pathogenesis....Pages 95-99
Investigations of Relapsing Fever at Home and Abroad....Pages 101-106
Molecular Sleuthing with the Lyme Disease Agent....Pages 107-115
Modeling of Acute Respiratory Melioidosis and Glanders....Pages 117-120
Front Matter....Pages 121-121
Cryptococcosis: From Discovering the Natural Reservoir of its Etiology to the Genetic Manipulation of Cryptococcus neoformans : Milestones in Cryptococcal Research by Intramural Investigators at NIAID....Pages 123-134
Front Matter....Pages 135-135
Lessons from Parasites on CD4 + T-Cell Subset Differentiation and Function....Pages 137-142
Molecular Aspects of Parasite – Vector Interactions In Leishmaniasis....Pages 143-149
Front Matter....Pages 151-151
Mosquito Strategies Against Plasmodium : A Tale of Restrained Response and Immune Evasion....Pages 153-159
The Plasmodial Surface Anion Channel: A Model Microbial Ion Channel and Target for Antimalarial Drug Development....Pages 161-167
Genomics and Genetics of Drug Resistance and Regulation of Malaria Parasite Development....Pages 169-175
Front Matter....Pages 177-177
Modulation of Human Dendritic Cells by Highly Virulent Pathogens....Pages 179-183
Front Matter....Pages 177-177
Making Friends in Out-of-the- Way Places: How Cells of the Immune System Get Together and How They Conduct Their Business as Revealed by Intravital Imaging....Pages 185-202
Role of Regulatory/Suppressor T Cells in Immune Responses....Pages 203-213
Proliferation versus Contraction of Immune Cells, the Non-Apoptotic Role of Caspase 8 In Immune Homeostasis....Pages 215-220
Features of Plasma Cell-Related Neoplasms in Mice....Pages 221-230
A Role of IRF8 in Transcriptional Control of B-Cell Development....Pages 231-241
Laboratory of Molecular Immunology....Pages 243-247
Front Matter....Pages 249-249
Structure and Function of Immunoreceptors....Pages 251-259
Role of the NKG2D Receptor in Health and Disease....Pages 261-273
Front Matter....Pages 275-275
G-Protein-Evoked Signaling Mechanisms in Asthma and Allergic Disease....Pages 277-281
Mast Cell Precursors and Signaling Pathways....Pages 283-295
Front Matter....Pages 297-297
Prion Biochemistry and Therapeutics....Pages 299-303
Neutrophils in the Resolution of Infection....Pages 305-310
Reactive Oxidant-Dependent Innate Immune Defenses of the Airway Epithelium: The Dual Oxidase-Lactoperoxidase-Thiocyanate System....Pages 311-318
Chronic Granulomatous Disease: From Lethal Pediatric Mystery to Complex Chronic Disease....Pages 319-352
Pneumonia Virus of Mice (PVM): Exploring Novel Therapeutic Options In a Severe Respiratory Disease Model....Pages 353-359
The 1918 Influenza Pandemic: Pathology and Pathogenesis....Pages 361-368
Front Matter....Pages 369-369
Mind Your Xs and Ys: Genetics of the Autoimmune Disease Systemic Lupus Erythematosus....Pages 371-376
A Bench-to-Bedside Trail of Research Leading to the Understanding and Treatment of Ulcerative Colitis....Pages 377-383
Front Matter....Pages 385-385
Structural Biology and the Design of Effective Vaccines for HIV-1 and Other Viruses....Pages 387-402
How Do You Say “B-Cell Biology” In “Vaccinology”: Translational Research In the NIAID....Pages 403-407
Front Matter....Pages 385-385
Malaria Vaccine Development....Pages 409-422
The Development of Live-Attenuated Vaccines for Pandemic Influenza....Pages 423-430
Targeting the Messenger: Vector-Based Vaccines to Control Leishmania Infection and Transmission....Pages 431-436
Back Matter....Pages 437-449