National Institute of Allergy and Infectious Diseases, NIH: Frontiers in Research

Front Matter....Pages i-xviii
National Institute of Allergy and Infectious Diseases (NIAID): An Overview....Pages 3-8
Biotools for Determining the Genetics of Susceptibility to Infectious Diseases and Expediting Research Translation Into Effective Countermeasures....Pages 13-17
Spore Surface Components and Protective Immunity to Bacillus anthracis ....Pages 19-23
New Candidate Anthrax Pathogenic Factors....Pages 25-36
 Ehrlichiae and Ehrlichioses: Pathogenesis and Vector Biology....Pages 37-46
Multiple Locus Variable Number Tandem Repeat (VNTR) Analysis (MLVA) of Brucella spp. Identifies Species-Specific Markers and Insights into Phylogenetic Relationships....Pages 47-54
Expression of the MtrC-MtrD-MtrE Efflux Pump in Neisseria gonorrhoeae and Bacterial Survival in the Presence of Antimicrobials....Pages 55-63
What can Mycobacteriophages Tell Us About Mycobacterium tuberculosis ?....Pages 67-76
Clinical Mycobacterium tuberculosis Strains Differ in their Intracellular Growth in Human Macrophages....Pages 77-81
Mechanisms of Latent Tuberculosis: Dormancy and Resuscitation of Mycobacterium tuberculosis ....Pages 83-90
Separating Latent and Acute Disease in the Diagnosis of Tuberculosis....Pages 91-99
Mutant Selection Window Hypothesis: A Framework for Anti-mutant Dosing of Antimicrobial Agents....Pages 101-106
The NIAID Influenza Genome Sequencing Project....Pages 109-113
Lessons From the 1918 Spanish Flu Epidemic in Iceland....Pages 115-122
Control of Notifiable Avian Influenza Infections in Poultry....Pages 123-129
Understanding the Complex Pathobiology of High Pathogenicity Avian Influenza Viruses in Birds....Pages 131-141
Development of Prophylactics and Therapeutics Against the Smallpox and Monkeypox Biothreat Agents....Pages 145-161
The Hierarchic Informational Technology for QSAR Investigations: Molecular Design of Antiviral Compounds....Pages 163-177
Antivirals for Influenza: Novel Agents and Approaches....Pages 179-192
Anti-Infectious Actions of Proteolysis Inhibitor ε-Aminocaproic Acid (ε-ACA)....Pages 193-198
A New Highly Potent Antienteroviral Compound....Pages 199-202
Reduction and Possible Mechanisms of Evolution of the Bacterial Genomes....Pages 205-214
Interaction of Yersinia pestis Virulence Factors with IL-1R/TLR Recognition System....Pages 215-225
IS481-Induced Variability of Bordetella pertussis ....Pages 227-231
Microarray Immunophosphorescence Technology for the Detection of Infectious Pathogens....Pages 233-240
Development of Immunodiagnostic Kits and Vaccines for Bacterial Infections....Pages 241-248
Research in Emerging and Re-emerging Diseases in Central Asia and the Caucasus: Contributions by the National Institute of Allergy and Infectious Diseases and the National Institutes of Health....Pages 251-252
Disease Surveillance in Georgia: Benefits of International Cooperation....Pages 253-255
Epidemiology (Including Molecular Epidemiology) of HIV, Hepatitis B and C in Georgia: Experience From U.S.—Georgian Collaboration....Pages 257-261
The National Tuberculosis Program in the Country of Georgia: An Overview....Pages 263-267
Virus Receptor Wars: Entry Molecules Used for and Against Viruses Associated with AIDS....Pages 271-277
HIV Latency and Reactivation: The Early Years....Pages 279-287
HIV-1 Sequence Diversity as a Window Into HIV-1 Biology....Pages 289-297
Human Monoclonal Antibodies Against HIV and Emerging Viruses....Pages 299-308
Biological Basis and Clinical Significance of HIV Resistance to Antiviral Drugs....Pages 309-318
NIAID HIV/AIDS Prevention Research....Pages 319-325
Epidemiological Surveillance of HIV and AIDS in Lithuania....Pages 327-337
TACI, Isotype Switching, CVID, and IgAD....Pages 343-348
A Tapestry of Immunotherapeutic Fusion Proteins: From Signal Conversion to Auto-stimulation....Pages 349-356
A Role for Complement System in Mobilization and Homing of Hematopoietic Stem/Progenitor Cells....Pages 357-364
Post-translational Processing of Human Interferon- γ Produced in Escherichia coli and Approaches for its Prevention....Pages 365-373
B-cell Dysfunctions in Autoimmune Diseases....Pages 377-384
A Model System for Studying Mechanisms of B-cell Transformation in Systemic Autoimmunity....Pages 385-396
Breach and Restoration of B-cell Tolerance in Human Systemic Lupus Erythematosus (SLE)....Pages 397-406
Dendritic Cells: Biological and Pathological Aspects....Pages 409-427
Immunomic and Bioinformatics Analysis of Host Immunity in the Vaccinia Virus and Influenza A Systems....Pages 429-434
Immunoreactions to Hantaviruses....Pages 435-444
Innate Immunity to Mouse Cytomegalovirus....Pages 445-456
Research and Development of Chimeric Flavivirus Vaccines....Pages 459-471
Correlates of Immunity Elicited by Live Yersinia pestis Vaccine....Pages 473-480
Strategies for a Competitive Research Career....Pages 483-485
Selecting the Appropriate Funding Mechanism....Pages 487-495
Preparing and Submitting a Competitive Grant Application....Pages 497-505
Identifying Research Resources and Funding Opportunities....Pages 507-517
Back Matter....Pages 519-530