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ویرایش: [I, 1 ed.] نویسندگان: Ramesh Chandra, Nidhi Gupta, Surendra Nimesh سری: ISBN (شابک) : 9781681087818, 9781681087832 ناشر: Bentham Science Publishers سال نشر: 2021 تعداد صفحات: 314 [316] زبان: English فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) حجم فایل: 17 Mb
در صورت تبدیل فایل کتاب Nanomaterials: Evolution and Advancement Towards Therapeutic Drug Delivery (Part I) به فرمت های PDF، EPUB، AZW3، MOBI و یا DJVU می توانید به پشتیبان اطلاع دهید تا فایل مورد نظر را تبدیل نمایند.
توجه داشته باشید کتاب نانومواد: تکامل و پیشرفت به سوی دارورسانی درمانی (قسمت اول) نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
توسعه ناقلی برای تحویل داروهای درمانی به شیوه ای کنترل شده و هدفمند هنوز یک چالش بزرگ در درمان بسیاری از بیماری ها است. کاربرد مرسوم داروها ممکن است به محدودیتهای زیادی از جمله توزیع ضعیف، اثربخشی محدود، عدم انتخابپذیری و سمیت وابسته به دوز منجر شود. یک سیستم دارورسانی کارآمد می تواند این مشکلات را برطرف کند. پیشرفتهای اخیر فناوری نانو در زمینه زیستپزشکی این پتانسیل را دارد که با این چالشها در توسعه سیستمهای دارورسانی مقابله کند. نانومواد در حال تغییر بستر زیست پزشکی از نظر تشخیص، درمان و پیشگیری از بیماری هستند. انتقال دارو به کمک نانومواد با افزایش حلالیت آبی که منجر به بهبود فراهمی زیستی، افزایش زمان مقاومت در بدن، کاهش عوارض جانبی با هدف قرار دادن داروها به محل خاص، کاهش سمیت وابسته به دوز و محافظت از داروها از انتشار زودرس میشود، مزیتی را فراهم میکند. در این جلد، مشارکتکنندگان گزارشهایی از مطالعات اخیر را گردآوری کردهاند که نشاندهنده نانومواد امیدوارکنندهای است که میتوانند به عنوان حامل دارو عمل کنند و میتوانند موانع فیزیولوژیکی معمولی را عبور دهند. شرح مفصلی از انواع مختلفی از نانومواد از جمله نانوذرات پلیمری، لیپوزوم ها، دندریمرها، میسل ها، نانومواد کربنی، نانوذرات مغناطیسی، نانوذرات جامد مبتنی بر لیپید، نانومواد سیلیسی و هیدروژل ها برای تحویل دارو در فصل های جداگانه ارائه شده است. مشارکتکنندگان همچنین بحثی را در مورد جنبههای بالینی تحقیقات در حال انجام با بینشهایی نسبت به چشمانداز آینده فناوریهای نانو خاص ارائه میکنند. این کتاب یک منبع آموزنده برای محققانی است که به دنبال به روز رسانی در نانوپزشکی با اشاره به نانومواد مورد استفاده در سیستم های دارورسانی هستند.
The development of a vector for the delivery of therapeutic drugs in a controlled and targeted fashion is still a major challenge in the treatment of many diseases. The conventional application of drugs may lead to many limitations including poor distribution, limited effectiveness, lack of selectivity and dose dependent toxicity. An efficient drug delivery system can address these problems. Recent nanotechnology advancements in the biomedical field have the potential to meet these challenges in developing drug delivery systems. Nanomaterials are changing the biomedical platform in terms of disease diagnosis, treatment and prevention. Nanomaterials aided drug delivery provides an advantage by enhancing aqueous solubility that leads to improved bioavailability, increased resistance time in the body, decreased side effects by targeting drugs to the specific location, reduced dose dependent toxicity and protection of drugs from early release. In this volume, the contributors have compiled reports of recent studies illustrating the promising nanomaterials that can work as drug carriers, that can navigate conventional physiological barriers. A detailed account of several types of nanomaterials including polymeric nanoparticles, liposomes, dendrimers, micelles, carbon nanomaterials, magnetic nanoparticles, solid lipid-based nanoparticles, silica nanomaterials and hydrogels for drug delivery is provided in separate chapters. The contributors also present a discussion on clinical aspects of ongoing research with insights towards future prospects of specific nanotechnologies. The book is an informative resource for scholars who seek updates in nanomedicine with reference to nanomaterials used in drug delivery systems.
Cover Title Copyright End User License Agreement Contents Foreword Preface List of Contributors Polymeric Nanoparticles as a Promising Drug Delivery Vehicle Nidhi Gupta1, Ramesh Chandra2 and Surendra Nimesh3,* INTRODUCTION POLYMERIC NANOPARTICLES FOR DNA/SIRNA DELIVERY ADVANTAGES AND LIMITATIONS OF NANOPARTICLES CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Characterization of Nanostructured Systems for Bioactive Compound Delivery Gabriel Silva Borges1, Flávia Lidiane Oliveira da Silva2, Osmar Patrício Almeida2, Taízia Dutra Silva2 and Guilherme Carneiro2,* INTRODUCTION SIZE ANALYSIS Dynamic Light Scattering Equipment Performing the Technique Analyzing the Results Laser Diffraction Equipment Performing the Technique Analyzing the Results Zeta Potential Equipment Performing the Technique Analyzing the Results MORPHOLOGY Optical Microscopy Types of Optical Microscopy Applications Scanning Electron Microscopy Principles of the Technique Equipment Environmental SEM Applications Transmission Electron Microscopy Equipment Principles of the Technique Scanning Transmission Electron Microscopy and Environmental Transmission Electron Microscopy Applications Atomic Force Microscopy Equipment Principles of the Technique Sample Preparation and Data Analysis Applications Confocal Fluorescence Microscopy Principles of Technique and Equipment Applications CRYSTALLINE STATE, POLYMORPHISM AND DRUG NANOSYSTEM INTERACTION Infrared Spectroscopy Ultraviolet-visible Spectroscopy X-ray Diffraction Small-angle Scattering of X-rays Thermal Analyses Differential Scanning Calorimetry Differential Thermal Analysis Events Detected in DSC and DTA Applications of DSC and DTA TGA Applications of TGA CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Liposomes: The New Developments in Topical Drug Delivery Gajanand Sharma1, Kanika Thakur1, Nitika Dehal1, Akanksha Mahajan1, Kaisar Raza2 and O.P. Katare1,* INTRODUCTION COMPOSITION OF LIPOSOMES Phospholipid Natural Phospholipids Synthetic Phospholipids Cholesterol CLASSIFICATION OF LIPOSOMES Based on Structural Parameters Based on the Method of Preparation Based on Composition and Applications PREPARATION OF LIPOSOMES Conventional Methods Novel Methods Supercritical Fluid Technology Dual Asymmetric Centrifugation (DAC) Freeze Drying Technology Cross-flow Filtration Technology Membrane Contactor Technology CHARACTERIZATION OF LIPOSOMES Physical Characterization Vesicle Shape and Lamellarity Vesicle Size and Size Distribution Optical Microscopy Negative Stain Transmission Electron Microscopy (TEM) Cryo-TEM Small Angle X-ray Scattering (SAXS) Atomic Force Microscopy (AFM) Dynamic Light Scattering (DLS) Field Flow Fractionation (FFF) Technique Size Exclusion Chromatography (SEC) Nanoparticle Tracking Analysis (NTA) Entrapment Efficiency (EE) Surface Charge Chemical Characterization Biological Characterization LIPOSOMAL DRUG LOADING METHODS Passive Loading Method Active (remote) Loading Method TARGETING STRATEGIES FOR LIPOSOMES Passive Targeting Active Targeting Triggered Drug Targeting pH Sensitive Liposomes External Stimuli-dependent Release Magnetically Sensitive Liposomes Electro Responsive Liposomes APPLICATIONS OF LIPOSOMES Liposomes for Topical Delivery Liposomes for Pulmonary Delivery Liposomes for Ophthalmic Delivery Liposomes for Parenteral Delivery Liposomes for Oral Delivery Liposomes as Vaccine Delivery CLINICAL USES OF LIPOSOMAL DRUGS CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Role of Dendrimers in Drug Delivery and Targeting Sarita Rani, Neetu Sehrawat, Sudhakar Rajoria and Umesh Gupta* INTRODUCTION Synthetic Approaches Divergent Method Convergent Method Dendrimer-drug Interactions Non-Covalent Interactions Covalent Interactions Properties Monodispersity Size and Shape Biocompatibility Surface Charge Toxicity and Surface Functionality Pharmacokinetics Types of Dendrimers PAMAM Dendrimers PPI Dendrimers Peptide Dendrimers Glycodendrimers Tecto/Core-shell Dendrimers Chiral Dendrimers Triazine Dendrimers Poly-L-lysine Dendrimers Applications of Dendrimers Dendrimers in Cancer Therapy Dendrimer in Infectious Diseases Dendrimers in Ocular Diseases Dendrimer in Dermatological Diseases Dendrimer in CNS Disorders Dendrimers in Cardiovascular Diseases/Hypertension Dendrimers in Ulcerative Colitis Diseases CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Chronicle of Nanomicelles in Drug Delivery: From Bench to Bedside Neha Bajwa1, Preet Amol Singh1, Vaskuri G.S. Sainaga Jyothi2, Rupinder Kaur Sodhi3, Ashish Baldi1, Satish Sardana4, Ramesh Chandra5,6 and Jitender Madan2,* INTRODUCTION Principle of Micelles Formation Amphiphilic Copolymers Micellization of Amphiphilic Block Copolymers Characterization of Polymeric Micelles Shape of Polymeric Micelles Size of Polymeric Micelles Critical Micelles Concentration (CMC) Determination Stability Studies of Polymeric Micelles Synthesis of Drug Conjugated Polymeric Micelles Drug Incorporation in Polymeric Micelles Drug Solubilization Capacity of the Polymeric Micelles Drug partitioning in Polymeric Micelles Drug Release from Polymeric Micelles Sustained and Controlled Drug Release pH Sensitive Drug Release Pharmaceutical Applications of Polymeric Micelles Polymeric Micelles as Solubilizing Agents for Poorly Soluble Drugs Sustained Release Profile of Polymeric Micelles Polymeric Micelles Drug Steering Application Application of Polymeric Micelles in Drug Delivery Through Different Routes of Administration Application of Polymeric Micelles in Diagnostics Clinical Applications of Nanomicelles and Regulatory Approval CONCLUSION CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Potential and Promises of Carbon Nanotubes in Drug Delivery Nagarani Thotakura, Vipin Kumar and Kaisar Raza* INTRODUCTION METHODS INVOLVED IN SYNTHESIS OF CNTS Arc Discharge Method Laser Ablation Method Chemical Vapor Deposition (CVD) Flame Pyrolysis COMMON CHEMICAL REACTIONS OF CNTS Covalent Attachment of Functional Groups Sidewall Halogenation of CNTs Hydrogenation Ozonolysis Mechanochemical Reactions Plasma Activation Nucleophilic Additions Noncovalent Interactions Endohedral Filling APPLICATIONS OF CNTS Artificial Implants Preservatives Diagnostic Tool As a Catalyst Formation of Batteries Solar Cells Transistors CNTS AS DELIVERY VEHICLES Peptide Delivery Cellular Uptake of CNTs Delivery of Nucleic Acids Drug Delivery Using CNTs PHARMACOKINETICS AND BIODISTRIBUTION STUDIES OF CNTS ABSORPTION Distribution Metabolism Elimination SAFETY CONCERNS AND CHALLENGES CONCLUSIONS CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Magnetic Nanoparticles for Advanced Drug Delivery System Arindam Saha* and P. Sujatha Devi* INTRODUCTION TYPES OF MAGNETIC NANOPARTICLES Metal Nanoparticles Magnetic Alloys Magnetic Oxide Nanoparticles Ferrite Nanoparticle SYNTHESIS OF MAGNETIC NANOPARTICLES Electron Beam Lithography Gas Phase Deposition Sol-Gel Technique Co-Precipitation Method Micro-Emulsion Method Thermal Decomposition Method Polyol Method Sonochemical Method Vapour Phase or Aerosol Method Electrochemical Method Flow Injection Method Super-Critical Fluid Method Oxidation Method Microbial Method SURFACE MODIFICATION OF MAGNETIC NANOPARTICLES Surface Coating Organic Material Inorganic Materials Surface Functionalization DRUG LOADING ON MAGNETIC NANOPARTICLES STIMULI RESPONSIVE DRUG RELEASE MULTIFUNCTIONAL APPLICATIONS OF MAGNETIC NANOPARTICLES Imaging Therapy Cell/Protein Separation EFFECT OF SHAPE/SIZE OF MAGNETIC NANOPARTICLES ON DRUG LOADING/RELEASE QUANTITATIVE ESTIMATION OF DRUG LOADING AND RELEASE ADVANTAGES AND DISADVANTAGES OF MAGNETIC NANOPARTICLES CONCLUSION AND FUTURE CHALLENGES CONSENT FOR PUBLICATION CONFLICT OF INTEREST ACKNOWLEDGEMENTS REFERENCES Subject Index Back Cover