Myocardial and Skeletal Muscle Bioenergetics

Front Matter....Pages i-xiv
The Physiological Significance of the Creatine Phosphate Shuttle....Pages 1-11
Organization of the Mitochondrial Matrix....Pages 13-25
The Time Course of ATP Cleavage by Contracting Amphibian and Mammalian Skeletal Muscles....Pages 27-40
Isozymes of Creatine Kinase in Mammalian Myocardial Cell Culture....Pages 41-53
Microcompartmentation at the Mitochondrial Surface: Its Function in Metabolic Regulation....Pages 55-69
The Effect of Inorganic Phosphate on Mitochondrial, Creatine Kinase....Pages 71-82
Hormonal Regulation of Creatine Kinase BB....Pages 83-101
Compartmentation of Adenine Nucleotides and Phosphocreatine Shuttle in Cardiac Cells: Some New Evidence....Pages 103-116
Compartmentation of Hormone Action in Adult Mammalian Cardiomyocytes....Pages 117-127
Function of Creatine Kinase Localization in Muscle Contraction....Pages 129-137
Isotope Labeling Ratios: A Tool for the Exploration of Metabolic Compartments....Pages 139-150
The Mitochondrial Creatine Phosphokinase is Associated with Inner Membrane Cardiolipin....Pages 151-156
A Role for Mitochondria in Myocardial Adenosine Production....Pages 157-167
Aspects of Heart Respiratory Control by the Mitochondrial Isozyme of Creatine Kinase....Pages 169-191
Control of Respiration in Intact Muscle....Pages 193-212
Energy Compartmentation and Active Transport in Proximal Kidney Tubules....Pages 213-228
The Oxygen Dependence of Cellular Energy Metabolism....Pages 229-239
Regulation of Mitochondrial Respiration in Liver....Pages 241-254
Quantitation of Fluxes in the Gluconeogenic, Glycolytic, and Pentose Phosphate Pathways in Isolated Rat Hepatocytes: Energetic Considerations....Pages 255-270
Why is There a Delay in the Increased Oxygen Consumption during the Rest-Work Transition in Skeletal Muscle?....Pages 271-281
Compartmentation and Functional Mechanisms in Myocardial Failure and Myocardial Infarction....Pages 283-296
Myocardial Protection of Hypertrophied Hearts by Administration of Cardioplegia According to Regional Myocardial Temperature....Pages 297-302
Heart Myocytes as Models of the Cellular Response to Ischemia....Pages 303-314
Biologic Basis for Limitation of Infarct Size....Pages 315-330
Mitochondrial Transmembrane Proton Electrochemical Potential, Di- and Tricarboxylate Distribution and the Poise of the Malate-Aspartate Cycle in the Intact Myocardium....Pages 331-341
Sarcomere Length-Tension Relationship in Toad Atrioventricular Pacemaker: Length Dependent Activation....Pages 343-353
Myocardial Acidosis and the Mitigation of Tissue ATP Depletion in Ischemic Cardiac Muscle: The Role of the Mitochondrial ATPase....Pages 355-373
Vascular Metabolism and Energetics....Pages 375-387
Myocardial Glutamate Dehydrogenase Activity....Pages 389-400
Long Term Model for Evaluation of Myocardial Metabolic Recovery following Global Ischemia....Pages 401-414
The Effect of Reperfusion and Streptokinase on Ischemic Myocardium Serum Creatine Kinase Activity, MM Subtypes and Myocardial Blood Flow....Pages 415-425
Post-Contracture Reperfusion: Effect of Elevated Potassium and Verapamil....Pages 427-437
Ultrastructure of the Human Myocardium after Intermittent Ischemia Compared to Cardioplegia....Pages 439-449
Cellular Injury in Phosphate Depletion: Pathogenesis and Mechanisms in the Myocardium....Pages 451-467
Diabetes Mellitus and Hypothyroidism Induce Changes in Myosin Isoenzyme Distribution in the Rat Heart — Do Alterations in Fuel Flux Mediate These Changes?....Pages 469-479
Glycerol Kinase Deficiency: Compartmental Considerations Regarding Pathogenesis and Clinical Heterogeneity....Pages 481-493
Phosphorylated Nucleotides and Glycolytic Intermediates in Diabetic and Non-Diabetic Rat Uterus in Late Pregnancy....Pages 495-501
Effect of Calcium Antagonists on Vasopressin Induced Changes in Myocardial and Renal Pyridine Nucleotides in the Intact Rat....Pages 503-517
The Effect of Creatine Analogue Substitution on the Post Tetanic Response of Fast Muscle....Pages 519-525
Calcium Compartmentation in Mammalian Myocardium....Pages 527-533
Calcium Channel Blockers, Beta Blockers and the Maintenance of Calcium Homeostasis....Pages 535-556
Sodium-Calcium Exchange: Calcium Regulation at the Sarcolemma....Pages 557-562
The Calcium Pumping ATPase of Heart Plasma Membrane....Pages 563-572
Calcium Compartmentation and Regulation in Myocytes....Pages 573-590
Ca ++ -Dependent and Ca ++ -Independent Effects of Mg ++ on Canine Right Atria....Pages 591-598
Chronotropic and Inotropic Effects of [Mg ++ ] o Not Dependent Upon [Ca ++ ] o ....Pages 599-600
Sodium Modulation of Resting Force, Contractile Properties, and Metabolism with Particular Emphasis on Its Role in the Development of Calcium Overload States....Pages 601-615
The Effect of Short Chain Fatty Acid Administration on Hepatic Glucose, Phosphate, Magnesium and Calcium Metabolism....Pages 617-646
Lessons for Muscle Energetics from 31 P NMR Spectroscopy....Pages 647-663
Metabolic Depletion Preceding Cytolysis Induced By Antibody And Complement As Revealed By 31 P-NMR Spectroscopy....Pages 665-674
Back Matter....Pages 675-678