Myelination and Demyelination

Front Matter....Pages i-xii
Introduction and Comments....Pages 1-16
Front Matter....Pages 17-17
Biosynthesis of Myelin and Neurotoxic Factors in the Serum of Multiple Sclerosis Patients....Pages 19-25
Lipid and Fatty Acid Composition of Human Cerebral Myelin during Development....Pages 27-41
Enzymic Studies on Glial and Neuronal Cells during Myelination....Pages 43-53
Regional Developmental and Fractional Studies on Myelin and Other Carbonic Anhydrases in Rat CNS....Pages 55-69
Studies of Isolated, Maintained Oligodendroglia: Biochemistry, Metabolism, and In Vitro Myelin Synthesis....Pages 71-94
Studies on Myelin Proteins in Human Peripheral Nerve....Pages 95-115
Protein Heterogeneity in Rat CNS Myelin Subfractions....Pages 117-133
The Preparation and Analysis of Myelin from Small Quantities of Central Nervous Tissue: Regional Studies of the Quaking Mouse....Pages 135-145
Studies on the Action of Myelin Basic Protein (MBP) in Rat Brain....Pages 147-157
 In Vivo Incorporation of 32 P into Myelin Basic Protein from Normal and Quaking Mice....Pages 159-170
Abnormal Myelin Maturation In Vitro : the Role of Cerebrosides....Pages 171-178
Retardation of Brain Myelination by Malnourishment and Feeding Low Protein Irradiated Diet in Rats....Pages 179-186
The Molecular Architecture of Myelin: Identification of the External Surface Membrane Components....Pages 189-205
Conformation of Myelin Basic Protein and Its Role in Myelin Formation....Pages 207-220
Cross-Linking of Lipid Bilayers by Central Nervous System Myelin Basic Protein: Aggregation of Free and Vesicle-Bound Protein....Pages 221-234
Molecular Organisation in Central Nerve Myelin....Pages 235-248
Covalent Probe Investigations with Isolated Central Nerve Myelin Preparations....Pages 249-261
On the Accessibility and Localisation of Cerebrosides in Central Nervous System Myelin....Pages 263-273
Front Matter....Pages 275-275
Autoimmunity in Multiple Sclerosis: Do we have an Experimental Model?....Pages 277-288
Front Matter....Pages 275-275
Molecular Bases for the Difference in the Potency of Myelin Basic Protein from Different Species in Lewis Rats....Pages 289-301
Comparison of the Rat and Mouse Encephalitogenic Determinants....Pages 303-305
The Action of Trypsin on Central and Peripheral Nerve Myelin....Pages 307-328
Clearance of Myelin Basic Protein from Blood of Normal and EAE Rabbits....Pages 329-346
Basic Protein Hydrolysis in Lymphocytes of Lewis Rats with Experimental Allergic Encephalomyelitis....Pages 347-363
Neutral Proteinases Secreted by Macrophages Degrade Basic Protein: A Possible Mechanism of Inflammatory Demyelination....Pages 365-381
Virus Infection in Demyelinating Diseases....Pages 383-394
Early and Late CNS-Effects of Corona Virus Infection in Rats....Pages 395-409
A Search for the “Multiple Sclerosis Virus” — Lack of Effect of Brain Extracts on Myelin Development in Chickens, Mice and Rats....Pages 411-422
Plasmalogenase is Elevated in Early Demyelinating Lesions....Pages 423-438
Effect of Diphtheritic Demyelination on Axonal Transport in the Sciatic Nerve and Subsequent Muscle Changes in the Chicken....Pages 439-452
Myelin Deficiency in Experimental Phenylketonuria: Contribution of the Aromatic Acid Metabolites of Phenylalanine....Pages 453-469
Peripheral Nerves as Target Tissue of the Immune Response in Ean. A Neurochemical and Morphological Study....Pages 471-477
Biochemical Studies of CNS and PNS in Human and Experimental Diabetes....Pages 479-486
The Effect of Intoxication with Alkylnitrosourea Derivatives on Cerebral Myelin....Pages 487-498
Cellular and Humoral Responses to Myelin Basic Protein in Multiple Sclerosis: A Dichotomy....Pages 501-511
Cerebrospinal Fluid Myelin Basic Protein and Multiple Sclerosis....Pages 513-519
Proteolytic Activity in CSF....Pages 521-527
The Immune Response in Human Demyelinating Diseases....Pages 529-543
Isoelectric Focusing and Isotachophoresis for Investigation of CSF and Serum Proteins in Demyelinating and Infectious Neurological Diseases....Pages 545-559
Front Matter....Pages 275-275
Proliferating Cells in Demyelinating States....Pages 561-568
Topographic Analysis of MS and Control Brains....Pages 569-583
Biochemical Study on Myelin in Adrenoleukodystrophy....Pages 585-599
Metabolic Studies of Adrenoleukodystrophy....Pages 601-619
Virological Aspects of Multiple Sclerosis....Pages 623-624
The Role of Viruses in the Pathogenesis of Demyelinative Disorder....Pages 625-626
Jejunal Viral Antigen in Multiple Sclerosis and Amyotrophic Lateral Sclerosis....Pages 627-632
Aspects of the Viral Antibody Response in Multiple Sclerosis....Pages 633-635
Autoimmunity to Receptors as a Possible Cause of Multiple Sclerosis....Pages 637-638
Immunoglobulins in Multiple Sclerosis....Pages 639-640
Summary of the General Discussion on the Possible Viral Etiology of Multiple Sclerosis....Pages 641-642
Back Matter....Pages 643-651