Mutation and Evolution

Front Matter....Pages i-2
Some evolutionary consequences of deleterious mutations....Pages 3-19
Risk of population extinction from fixation of deleterious and reverse mutations....Pages 21-27
Deleterious mutation accumulation in organelle genomes....Pages 29-39
Mutation-selection balance with multiple alleles....Pages 41-47
Mutation pressure, natural selection, and the evolution of base composition in Drosophila ....Pages 49-60
Deleterious mutations in animal mitochondrial DNA....Pages 61-69
Requisite mutational load, pathway epistasis, and deterministic mutation accumulation in sexual versus asexual populations....Pages 71-81
Evolution by nearly-neutral mutations....Pages 83-90
Compensatory neutral mutations and the evolution of RNA....Pages 91-101
The amount and pattern of DNA polymorphism under the neutral mutation hypothesis....Pages 103-107
Adaptive mutagenesis: a process that generates almost exclusively beneficial mutations....Pages 109-125
The fate of competing beneficial mutations in an asexual population....Pages 127-144
An embarrassment of riches: the stochastic generation of beneficial mutations....Pages 145-155
Selection, convergence, and intragenic recombination in HLA diversity....Pages 157-169
Mutation and conflicts between artificial and natural selection for quantitative traits....Pages 171-181
Measuring spontaneous deleterious mutation process....Pages 183-197
Polygenic mutation in Drosophila melanogaster : genotype × environment interaction for spontaneous mutations affecting bristle number....Pages 199-215
Environment-influenced expression of polygene mutations isolated from a natural population of Drosophila melanogaster ....Pages 217-228
Inferences on genome-wide deleterious mutation rates in inbred populations of Drosophila and mice....Pages 229-239
How should we explain variation in the genetic variance of traits?....Pages 241-253
The mutation rate and the distribution of mutational effects of viability and fitness in Drosophila melanogaster ....Pages 255-265
Evolution of intermediate selfing rates in plants: pollination ecology versus deleterious mutations....Pages 267-278
Mathematical properties of mutation-selection models....Pages 279-298
Mutation and senescence: where genetics and demography meet....Pages 299-314
Spontaneous mutation for life-history traits in Drosophila melanogaster ....Pages 315-324
Mutation rates in mangroves and other plants....Pages 325-331
Asymmetrical DNA replication promotes evolution: disparity theory of evolution....Pages 333-347
Distribution of fitness effects caused by random insertion mutations in Escherichia coli ....Pages 349-358
Mutation and evolution of microsatellites in Drosophila melanogaster ....Pages 359-367
The molecular clock revisited: the rate of synonymous vs. replacement change in Drosophila ....Pages 369-382
Directional mutational pressure affects the amino acid composition and hydrophobicity of proteins in bacteria....Pages 383-391
Mutation and selection at silent and replacement sites in the evolution of animal mitochondrial DNA....Pages 393-407
Enigma of Y chromosome degeneration: Neo-Y and Neo-X chromosomes of Drosophila miranda a model for sex chromosome evolution....Pages 409-420
The developmental basis for germline mosaicism in mouse and Drosophila melanogaster ....Pages 421-443
Major impacts of gonadal mosaicism on hereditary risk estimation, origin of hereditary diseases, and evolution....Pages 445-462
Discovery of numerous clusters of spontaneous mutations in the specific-locus test in mice necessitates major increases in estimates of doubling doses....Pages 463-487
Clusters of new identical mutants and the fate of underdominant mutations....Pages 489-505
Mutation and selection within the individual....Pages 507-524
Towards a theory of evolutionary adaptation....Pages 525-533
A pleiotropic model of phenotypic evolution....Pages 535-543
Population differentiation through mutation and drift — a comparison of genetic identity measures....Pages 545-558
Inferring the major genomic mode of dominance and overdominance....Pages 559-567
Genetic measurement theory of epistatic effects....Pages 569-580