Multiscale Modeling of Vascular Dynamics of Micro- and Nano-particles: Application to Drug Delivery System

PRELIMS.pdf
	Preface
	Acknowledgements
	Author biographies
		Huilin Ye
		Zhiqiang Shen
		Ying Li
	Symbols
CH001.pdf
	Chapter 1 Background
		1.1 Blood flow in human vasculature
		1.2 Vascular targeting and margination of particles in blood flow
		1.3 Adhesion of particles on endothelium wall
		References
CH002.pdf
	Chapter 2 Numerical methods: fluid–structure interaction and adhesive dynamics
		2.1 Fluid–structure interaction
			2.1.1 Plasma dynamics: lattice Boltzmann method
			2.1.2 Coarse-grained model for blood cells and particles
			2.1.3 Immersed boundary method
		2.2 Adhesive dynamics
		2.3 Validation of numerical method
			2.3.1 Validation of red blood cell model
			2.3.2 Validation of red blood cell suspension
		References
CH003.pdf
	Chapter 3 Anomalous vascular dynamics of nanoworms within blood flow
		3.1 Motivation
		3.2 Experimental and computational results
			3.2.1 Experiment
			3.2.2 Computational results
		References
CH004.pdf
	Chapter 4 Adhesion behavior of a single cell on the endothelial wall
		4.1 Introduction
		4.2 Computational model
		4.3 Results and discussion
			4.3.1 Four types of motion and demargination
			4.3.2 Effect of particle stiffness on the formation of bonds and adhesive force
			4.3.3 Phase diagram and scaling relationship
		References
CH005.pdf
	Chapter 5 Localization of soft particles: margination and adhesion
		5.1 Introduction
		5.2 Physical problem and computational method
			5.2.1 Physical problem
		5.3 Results and discussion
			5.3.1 Margination of elastic MPs without adhesion
			5.3.2 Adhesion effect on localization of elastic MPs at the wall
			5.3.3 Adhesion behavior of elastic MPs
			5.3.4 Mechanism of localization of elastic MPs under adhesion
		References
CH006.pdf
	Chapter 6 Shape-dependent transport of micro-particles in blood flow: from margination to adhesion
		6.1 Introduction
		6.2 Computational model setup
		6.3 Results and discussion
			6.3.1 Margination of MPs without adhesion
			6.3.2 Margination of MPs with adhesion
			6.3.3 Mechanism of adhesion effect on margination behavior
		References
CH007.pdf
	Chapter 7 Conclusion and perspective
		References
APP1.pdf
	Chapter