Multidisciplinary Management of Rectal Cancer: Questions and Answers

Front Matter....Pages i-xii
Front Matter....Pages 1-1
What Do We Consider Cancer of the Rectum?....Pages 3-8
What Is the Ongoing Recommendation in the Management of Rectal Cancer?....Pages 9-18
Front Matter....Pages 19-19
What Prognostic Clinical Factors Must Be Considered Before Treatment?....Pages 21-26
What Are the Relevant Imaging Factors to Optimize Treatment Decisions?....Pages 27-39
What Biochemical and Molecular Biological Factors Have Greater Relevance to Treatment Decisions?....Pages 41-48
Do Different Populations of Rectal Cancer Exist?....Pages 49-55
Front Matter....Pages 57-57
How Can We Identify Tumour Penetration?....Pages 59-65
How Can We Identify Mesorectal Fascia Involvement?....Pages 67-71
How Can We Identify Nodal Involvement?....Pages 73-75
How Can We Identify Pathologic Complete Responders After Radiochemotherapy?....Pages 77-93
How Can We Identify Local Relapse?....Pages 95-102
Front Matter....Pages 103-103
When Should Preoperative Short-Course Radiotherapy or Long-Course Chemoradiotherapy Be Performed?....Pages 105-116
Should We Tailor the Delineation of Pelvic Structures According to Tumor Presentation?....Pages 117-127
What Is the Role of IMRT and IGRT in Rectal Cancer?....Pages 129-148
What Are the Dose-Volume Constraints to Reduce Late Toxicity?....Pages 149-154
What Is the Contribution of Intraoperative Radiotherapy (IORT) in Tailoring Local Therapy in Primary or Recurrent Rectal Cancer?....Pages 155-161
What Is the Contribution of Brachytherapy in Tailoring Local Therapy?....Pages 163-169
Front Matter....Pages 171-171
Should Oxaliplatin Be Added to Preoperative Chemoradiation?....Pages 173-179
Should Biologic Targeted Agents Be Combined with Preoperative Chemoradiation in Rectal Cancer?....Pages 181-191
Should Upfront Chemotherapy Precede Preoperative Chemoradiation and Surgery?....Pages 193-203
Front Matter....Pages 171-171
How to Achieve Long-Term Survival in Patients with Metastatic Rectal Cancer?....Pages 205-216
Will Adjuvant Chemotherapy Improve Outcome After Preoperative Chemoradiation?....Pages 217-225
Front Matter....Pages 227-227
How to Evaluate the Quality of Surgery? Suggestions for Critical Reading of Surgical and Pathological Reports....Pages 229-232
How Is Nerve-Sparing Surgery Well Performed?....Pages 233-247
Is Laparoscopic Rectal Surgery the Gold Standard?....Pages 249-256
Is a Diverting Stoma Always Necessary for a Low Anterior Resection of a Rectal Cancer?....Pages 257-259
Will Extralevator Abdominoperineal Excision Become the New Gold Standard?....Pages 261-273
Which Patients Do Benefit from Extended Resections in Case of Locally Advanced Rectal Cancer?....Pages 275-290
Can Standard Surgical Procedure Reliably Be Avoided in Major Responders After Radio(chemo)therapy?....Pages 291-302
Front Matter....Pages 303-303
What Is the Correct Procedure for Handling the Surgical Specimen?....Pages 305-318
What Is the Prognostic Value of (y)pT and (y)pN?....Pages 319-326
What Is the Prognostic Value of CRM Involvement?....Pages 327-331
What Is the Prognostic Value of TRG?....Pages 333-337
Front Matter....Pages 339-339
What Are the Recommendations to Ensure a Successful Multidisciplinary Team in Rectal Cancer?....Pages 341-350
What Is the Appropriate Timetable for Tailored Follow-up?....Pages 351-354
How Should Data Be Shared and Rapid Learning Health Care Promoted?....Pages 355-364
Back Matter....Pages 365-367