Monooxygenase, Peroxidase and Peroxygenase Properties and Mechanisms of Cytochrome P450

Front Matter....Pages i-xv
Monooxygenase, Peroxidase and Peroxygenase Properties and Reaction Mechanisms of Cytochrome P450 Enzymes....Pages 1-61
Oxidizing Intermediates in P450 Catalysis: A Case for Multiple Oxidants....Pages 63-81
Current Approaches for Investigating and Predicting Cytochrome P450 3A4-Ligand Interactions....Pages 83-105
Acyl-Carbon Bond Cleaving Cytochrome P450 Enzymes: CYP17A1, CYP19A1 and CYP51A1....Pages 107-130
Regioselective Versatility of Monooxygenase Reactions Catalyzed by CYP2B6 and CYP3A4: Examples with Single Substrates....Pages 131-149
Cytochrome P450 Enzymes in the Bioactivation of Polyunsaturated Fatty Acids and Their Role in Cardiovascular Disease....Pages 151-187
Monooxygenation of Small Hydrocarbons Catalyzed by Bacterial Cytochrome P450s....Pages 189-208
Use of Chemical Auxiliaries to Control P450 Enzymes for Predictable Oxidations at Unactivated C-H Bonds of Substrates....Pages 209-228
Cytochrome P450 Enzymes and Electrochemistry: Crosstalk with Electrodes as Redox Partners and Electron Sources....Pages 229-246
Mechanistic Basis of Electron Transfer to Cytochromes P450 by Natural Redox Partners and Artificial Donor Constructs....Pages 247-297
Biological Diversity of Cytochrome P450 Redox Partner Systems....Pages 299-317
Cytochrome P450cin (CYP176A1)....Pages 319-339
Fungal Unspecific Peroxygenases: Heme-Thiolate Proteins That Combine Peroxidase and Cytochrome P450 Properties....Pages 341-368