Mononitrates

Front Matter....Pages I-XI
Preface....Pages 1-2
Introductory Remarks on the Development of Isosorbide-5-Mononitrate....Pages 3-4
Front Matter....Pages 5-5
Nitrates: Mechanism of Vasodilation....Pages 7-16
Effect of Different Vasodilators on Epicardial Coronary Arteries....Pages 17-22
Effects of Isosorbide-5-Mononitrate on Hemodynamic Parameters and on Regional Myocardial Ischemia in Conscious Dogs....Pages 23-33
Isosorbide-5-Mononitrate Increases Cyclic Guanosine Monophosphate Concentration in Rat Aorta in Vitro and in Vivo....Pages 34-38
Activation of Counter-Regulatory Mechanisms on Administration of Equipotent Doses of Different Types of Vasodilators to Conscious Dogs....Pages 39-44
Differences in the Metabolism of Isosorbide-5-Mononitrate and Isosorbide Dinitrate and Their Consequences for Toxicologic Findings....Pages 45-49
Front Matter....Pages 51-51
Pharmacokinetics of ISDN, Sustained-Release ISDN, and IS-5-MN....Pages 53-66
Vascular Pharmacokinetics of Nitrates....Pages 67-72
Effect of Glyceryl Trinitrate, Isosorbide-5-Mononitrate, and Propranolol on Apparent Liver Blood Flow....Pages 73-77
Kinetics of IS-5-MN and Its Glucuronide in Patients with Renal Failure....Pages 78-85
Pharmacokinetics of IS-5-MN after Oral and Intravenous Administration in Patients with Hepatic Failure....Pages 86-91
Front Matter....Pages 93-93
Nitrate Tolerance: Animal Experiments and Clinical Studies in Heart Failure....Pages 95-100
Development and Disappearance of Tolerance to Organic Nitrates in Conscious Dogs....Pages 101-106
Tolerance and Rebound Phenomena in Nitrate Therapy....Pages 107-123
Tolerance to the Antiischemic Effect of Isosorbide Dinitrate during Continuous but not during Intermittent Oral Therapy....Pages 124-129
Clinical Relevance of Nitrate Tolerance....Pages 130-146
A Double-Blind Cross-Over Study on the Effectiveness and Possible Development of Tolerance during Long-Term Therapy with Isosorbide-5-Mononitrate or Isosorbide Dinitrate Slow-Release in Coronary Artery Disease....Pages 147-153
Nitrate Tolerance in Angina Pectoris....Pages 154-170
Front Matter....Pages 93-93
Comparison of the Hemodynamic Effects of Various Doses of Isosorbide-5-Mononitrate Following Single-Dose and Long-Term Administration in Patients with Coronary Heart Disease....Pages 171-187
Slow-Release Isosorbide-5-Mononitrate for the Treatment of Angina Pectoris: Duration of Effects....Pages 188-189
Front Matter....Pages 191-191
The Mechanism of Nitrates in the Relief of Rest Angina....Pages 193-200
Beneficial Effects of Isosorbide-5-Mononitrate on Exercise Performance in Patients with Chronic Stable Angina Pectoris....Pages 201-214
Comparison of Changes on Exercise-Induced Ischemia After a Single Oral Dose of IS-5-MN and ISDN....Pages 215-220
Double-Blind, Randomized Crossover Study on the Coronary Therapeutic Efficacy and Tolerance of IS-5-MN (ISMO 20) in Comparison with IS-5-MN + Metipranolol (ISMO-DISORAT 20/5) and Placebo....Pages 221-229
The Efficacy of IS-5-MN in Patients with Ischemic Heart Disease: A Pilot Study....Pages 230-234
Efficacy of Isosorbide-5-Mononitrate in the Prevention of Induced Attacks of Vasospastic Angina: Preliminary Results....Pages 235-244
Double-Blind-Comparison of the Effects of Nifedipine and Isosorbide-5-mononitrate on the Circulatory Response to Exercise, Exercise Tolerance, and ST-Segment Depression in Patients with Ischemic Heart Disease....Pages 245-253
Clinical Importance of the Coronary Steal Phenomenon: Are the Coronary Steal Phenomenon after Dipyridamole and the Antianginal Efficacy of Isosorbide Dinitrate or Nifedipine Related to Coronary Anatomy?....Pages 254-264
Effect of Nitroglycerin Patches on Hemodynamic and Exercise Parameters in Patients with Coronary Artery Disease compared with IS-5-MN and Placebo....Pages 265-269
Double-Blind, Cross-Over Study on the Antianginal Efficacy of IS-5-MN and ISDN s.r., a Multicenter Trial....Pages 270-276
Hemodynamic Effects of Isosorbide-5-Mononitrate in Patients with Coronary Artery Disease, at Rest and Under Exercise....Pages 277-287
The Effects of Isosorbide-5-Mononitrate on Left Ventricular Function Assessed by Systolic Time Intervals....Pages 288-291
Assessment of Changes in Left Ventricular Performance Induced by Nitrates at Rest Using an ECG-Gated Scintillation Probe Device....Pages 292-296
Front Matter....Pages 297-297
Nitrate Therapy of Congestive Heart Failure....Pages 299-305
Efficacy of IS-5-MN (ISMO 20) in Patients with Coronary Artery Disease and Impaired Left-Ventricular Function....Pages 306-310
Hemodynamic Effects of IS-5-MN in Patients with Congestive Heart Failure....Pages 311-315
Back Matter....Pages 317-320