Molecular Physiology and Pharmacology of Cardiac Ion Channels and Transporters

Front Matter....Pages i-xxii
Front Matter....Pages 1-1
Overview: Channels and channel proteins....Pages 3-15
The hyperpolarization-activated inward channel and cardiac pacemaker activity....Pages 17-30
The hyperpolarization-activated (i f ) current: Autonomic regulation and the control of pacing....Pages 31-37
Current understanding of the structure of the voltage-gated sodium channel....Pages 39-51
β-adrenergic regulation of cardiac Na + channel....Pages 53-62
L-type calcium channel structure and function....Pages 63-69
L-type Ca channel biophysics....Pages 71-80
ß-adrenergic and muscarinic regulation of L-type calcium current....Pages 81-91
Regulation of cardiac Ca 2+ channels by cGMP and NO....Pages 93-105
Diversity of voltage-dependent K channels....Pages 107-117
Cloned human heart delayed rectifier K+ channels....Pages 119-130
Primary structure and biophysical properties of inward rectifying K + channel family....Pages 131-139
Ca 2+ -independent transient outward current in mammalian heart....Pages 141-168
Delayed potassium channels in the heart: Regulatory and molecular properties....Pages 169-176
Muscarinic and purinergic regulation of cardiac K + channels....Pages 177-186
Chloride channels in heart....Pages 187-196
Properties of cardiac ATP-sensitive potassium channels....Pages 197-207
Physiological and molecular properties of cardiac gap junctions....Pages 209-221
Volume-regulated cardiac ion channels....Pages 223-229
Regulation of cardiac activity by ATP, a purine agonist....Pages 231-238
Front Matter....Pages 1-1
Developmental aspects of cardiac ion channels....Pages 241-249
Developmental changes and regulation of L-type calcium channels of myocardial cells and vascular smooth muscle cells....Pages 251-272
Pharmacology of calcium channel antagonists....Pages 275-289
Interactions of calcium antagonists and agonists with calcium channels in muscle cells....Pages 291-304
Pharmacological regulation of the cardiac ATP-sensitive K + channel....Pages 305-312
Fatty acids and cardiac K + channels....Pages 313-322
Sodium channels and block....Pages 323-329
Afterdepolarizations, triggered rhythms and cardiac arrhythmias....Pages 333-342
Transient inward current and triggered activity....Pages 343-349
The Na + -activated K + channel....Pages 351-355
Regulation of cardiac ATP-sensitive K channels during ischemia, hypoxia and impaired metabolism....Pages 357-371
Front Matter....Pages 373-373
Signaling of calcium release in cardiac muscle....Pages 375-380
Local calcium transients in voltage-clamped cardiac cells: Evoked ‘calcium sparks’....Pages 381-388
Sarcoplasmic reticulum ryanodine receptor/Ca 2+ release channel: A functional perspective....Pages 389-396
Molecular structure of calcium release channels....Pages 397-408
Sarcoplasmic reticulum Ca 2+ ATPases....Pages 411-425
Molecular structure and function of phospholamban....Pages 427-433
The Na + -Ca 2+ exchanger: Molecular aspects....Pages 435-445
Na/Ca exchanger: Molecular and cellular characteristics....Pages 447-455
The functional significance of sodium-calcium exchange....Pages 457-467
Front Matter....Pages 373-373
The physiology of the Na-Ca exchange....Pages 469-480
Regulation of cardiac relaxation....Pages 481-511
Evaluation of changes in myofibrillar Ca 2+ sensitivity in intact cardiac cells....Pages 513-529
α 1 -Adrenergic receptor-dependent regulation of myocardial contractility....Pages 531-539
Ca transport from the cytoplasm and dynamic cellular Ca balance in cardiac myocytes....Pages 541-551
Regulation of intracellular protons: Role of Na/H exchange in cardiac myocytes....Pages 555-561
Magnesium homeostasis and cardiac cell function....Pages 563-573
Na-K pump: Multiple isoforms and their roles in cardiac functions....Pages 575-581
Back Matter....Pages 583-602