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دانلود کتاب Molecular Pathology of Nervous System Tumors: Biological Stratification and Targeted Therapies
دانلود کتاب آسیب شناسی مولکولی تومورهای سیستم عصبی: طبقه بندی بیولوژیکی و درمان های هدفمند
مشخصات کتاب
Molecular Pathology of Nervous System Tumors: Biological Stratification and Targeted Therapies
ویرایش: 1 نویسندگان: Matthias A. Karajannis, David Zagzag (eds.) سری: Molecular Pathology Library 8 ISBN (شابک) : 9781493918294, 9781493918300 ناشر: Springer-Verlag New York سال نشر: 2015 تعداد صفحات: 256 زبان: English فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) حجم فایل: 21 مگابایت
قیمت کتاب (تومان) : 43,000
کلمات کلیدی مربوط به کتاب آسیب شناسی مولکولی تومورهای سیستم عصبی: طبقه بندی بیولوژیکی و درمان های هدفمند: آسیب شناسی، انکولوژی، جراحی مغز و اعصاب
در صورت تبدیل فایل کتاب Molecular Pathology of Nervous System Tumors: Biological Stratification and Targeted Therapies به فرمت های PDF، EPUB، AZW3، MOBI و یا DJVU می توانید به پشتیبان اطلاع دهید تا فایل مورد نظر را تبدیل نمایند.
توجه داشته باشید کتاب آسیب شناسی مولکولی تومورهای سیستم عصبی: طبقه بندی بیولوژیکی و درمان های هدفمند نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
توضیحاتی در مورد کتاب آسیب شناسی مولکولی تومورهای سیستم عصبی: طبقه بندی بیولوژیکی و درمان های هدفمند
این کتاب به‌عنوان راهنمای جامعی برای زمینه به سرعت در حال تکامل نوروپاتولوژی مولکولی تومورهای سیستم عصبی، و همچنین زیست‌شناسی زیربنایی و درمان‌های هدفمند مولکولی در حال ظهور است. تاکید ویژه بر تست‌های تشخیصی مولکولی در حال ظهور و ایجاد شده در آسیب‌شناسی عصبی، و همچنین درمان‌های هدفمند مولکولی داده می‌شود. این کتاب توسط نهادهای بیماری های بالینی- پاتولوژیک سازماندهی شده است و هر فصل توسط تیمی از متخصصان در زمینه آنها نوشته شده است.
آسیب شناسی مولکولی تومورهای سیستم عصبی برای پزشکان و دانشمندانی که درگیر یا علاقه مند به تشخیص و درمان به روز بیماران مبتلا به تومورهای مغزی هستند، بسیار مفید است.
توضیحاتی درمورد کتاب به خارجی
This book serves as a comprehensive guide to the rapidly evolving field of molecular neuropathology of nervous system tumors, as well as the underlying biology and emerging molecular targeted therapies. Special emphasis is given to already established and emerging molecular diagnostic tests in neuropathology, as well as molecular targeted therapies. The book is organized by clinico-pathologic disease entities, and each chapter is written by a team of experts in their field.
Molecular Pathology of Nervous System Tumors is of great value and utility for physicians and scientists involved with or interested in the up-to-date diagnosis and treatment of patients with brain tumors.
فهرست مطالب
Foreword Preface Contents Contributors 1: Hereditary Predisposition to Primary CNS Tumors Syndromes Associated with Glioma Neurofibromatosis Type I (NF1, von Recklinghausen’s Disease) Molecular Pathogenesis Gliomas Clinical Implications Molecular Targeted Therapies Li–Fraumeni Syndrome Molecular Pathogenesis Clinical Implications Constitutional Mismatch Repair Deficiency Syndrome Molecular Pathogenesis Brain Tumors Clinical Implications Melanoma Astrocytoma Syndrome Syndromes Associated with Medulloblastoma Gorlin Syndrome (Basal Cell Nevus Syndrome) Molecular Pathogenesis Medulloblastoma Meningioma Clinical Implications Brain Tumor-Polyposis Syndrome 2 (BTPS 2 or Turcot Type 2; Familial Adenomatosis Coli) Molecular Pathogenesis Clinical Implications Fanconi Anemia Cancer Predisposition Disorders Molecular Pathogenesis Clinical Implications Meningioma Tumor Specific Syndromes Subependymal Giant Cell Astrocytoma Molecular Pathogenesis Clinical Implications Atypical Teratoid Rhabdoid Tumor Molecular Pathogenesis Clinical Implications Hemangioblastoma Molecular Pathogenesis CNS Hemangioblastomas Clinical Implications Development of New Medications Cerebellar Dysplastic Gangliocytoma (Lhermitte–Duclos Disease) Brain Tumors Molecular Pathogenesis Clinical Implications Vestibular Schwannomas (Acoustic Neuromas) Molecular Pathogenesis Intracranial Tumors Spinal Tumors Clinical Implications Implications of Molecular Tumor Testing on Genetic Counseling Summary References 2: Brain Tumor Stem Cells Cancer Stem Cell Definition Brain Tumor Initiation Neurogenesis in the Adult Brain Gliomagenesis Identification of Brain Tumor Stem Cells Molecular Characteristics of Brain Tumor Stem Cells Molecular Markers Signaling Pathways Pathways Supporting Self-Renewal Pathways Promoting Differentiation Stem Cell Niche and Tumor Microenvironment Vascular Niche Hypoxic Niche Invasion Therapeutic Importance of Brain Tumor Stem Cells Therapy Resistance Chemotherapy Resistance Radioresistance Updates on Clinical Trials Targeting BTSCs Discussion References 3: Molecular Pathology Techniques Molecular Techniques in Clinical Practice Copy-Number Analysis Fluorescence In Situ Hybridization Array Comparative Genomic Hybridization Mutation Analysis Mutation-Specific Antibodies Sequencing MGMT Testing Expression Profiling Summary References 4: Low-Grade Gliomas Pathology Circumscribed Gliomas Pilocytic Astrocytoma Pilomyxoid Astrocytoma Subependymal Giant Cell Astrocytoma Pleomorphic Xanthoastrocytoma Diffuse Gliomas Angiocentric Glioma Diffuse Astrocytoma Oligodendroglial Tumors Pediatric Diffuse Gliomas New and Unclassifiable Entities Gene Expression Profiling Molecular Genetics and Signaling Pathways Genetic Predisposition to Low-Grade Glioma Circumscribed Gliomas BRAF and MAPK Alterations Oncogene-Induced Senescence PI3K/mTOR Diffuse Gliomas Whole Genome Sequencing Studies of Pediatric Low-Grade Glioma Compound Genetic Alterations Epigenetics Molecular Targeted Therapies MAP Kinase Pathway: BRAF Duplication/BRAF V600E/MAPK/ERK Targeting Agents mTOR Pathway: PI3-K/AKT/mTOR Targeting Agents IDH1/2 Mutation Inhibition References 5: Ependymoma Histopathology Cytogenetics and Molecular Genetics Gene Expression Profiling Prognostic Stratification Molecular Signaling Pathways Molecular Targeted Therapies Summary References 6: Adult High-Grade (Diffuse) Glioma Histopathology Cytogenetics and Molecular Genetics 1p/19q Co-deletion Chromosome 10 Deletion Chromosome 7 Amplification IDH1 and IDH2 ATRX Epigenetics and Gene Expression Profiling MGMT Glioma-CpG-Island Methylator Phenotype (G-CIMP) Gene Expression Subtypes Prognostic Stratification Molecular Signaling Pathways Molecular Targeted Therapies Conclusion References 7: Pediatric High-Grade Gliomas and DIPG Histopathology Epigenetics Cytogenetics Gene Expression Prognostic Stratification Molecular Signaling Pathways RTK/Ras/PI3K Pathway RB Pathway P53 Pathway Molecular Targeted Therapies Future Directions References 8: Oligodendroglial Tumors Oligodendroglioma: An Infiltrating Glioma Histopathology Clinical Behavior of Oligodendroglial Tumors Treatment of Oligodendroglial Tumors Molecular Genetics of ODG: Predictive, Prognostic, and the Impact on Treatment Decisions Gene Expression in OGD Epigenetics of ODG Future Directions References 9: Medulloblastoma and CNS Primitive Neuroectodermal Tumors Medulloblastoma Molecular Genetics of Medulloblastoma: A Historical Perspective Molecular Subgroups of Medulloblastoma: Discovery and Initial Characterization The Molecular Subgroup Concept WNT Medulloblastoma SHH Medulloblastoma Group 3 Medulloblastoma Group 4 Medulloblastoma Next-Generation Genomics of Medulloblastoma: Assigning Driver Genes to Medulloblastoma Subgroups Known Cancer Genes DDX3X Chromatin Modifiers Atypical Structural Variation in Medulloblastoma Preclinical Models of Medulloblastoma: Validating the Genetics of the Human Disease Translational Significance of the Medulloblastoma Genomics Era Molecular Classification and Risk-Stratification Targeting Medulloblastoma with Rational Therapies Summary CNS-PNET Somatic Copy Number Alterations Gene Mutations Signaling Pathways and Molecular Classification Medulloepithelioma, Ependymoblastoma, and ETANTR Summary References 10: Subependymal Giant Cell Astrocytoma Incidence and Prevalence Genetics and Oncogenesis Clinical Presentation Radiographic Characteristics Pathology Treatment Options Observation Surgery Medical Therapy Radiosurgery Outcomes References 11: Germ Cell Tumors Histopathology Germinoma Yolk Sac Tumor Embryonal Carcinoma Teratoma Mature Teratoma Immature Teratoma Congenital Teratoma Choriocarcinoma Mixed Germ Cell Tumors Ancillary Immunohistochemical Studies Histogenesis Cytogenetics and Molecular Genetics Gene Expression Profiling Prognostic Stratification and Treatment Molecular Signaling Pathways and Targeted Therapies References 12: Choroid Plexus Tumors Definition Clinical Features Epidemiology Clinical Presenting Features Imaging and Tumor Localization Pathology and Diagnostics Macroscopy Histopathology Immunohistochemistry Histological Differential Diagnosis Pathogenesis and Molecular Genetics Pathogenesis Clinical Aspects and Treatments Prognosis and Current Treatment Summary References 13: Atypical Teratoid Rhabdoid Tumors Definition Clinical Features Histopathology Macroscopy Histopathology Differential Diagnosis Immunohistochemistry Cytogenetics and Molecular Genetics Molecular Genetics Mutational Spectrum of SMARCB1 Found in AT/RT Molecular Diagnosis Prognostic Stratification and Treatments Prognosis and Treatment Chemotherapy High Dose Chemotherapy Radiation Therapy Molecular Signaling Pathways Molecular Targeted Therapies Summary References 14: Hemangioblastoma Genetics Pathogenesis Pathology Clinical Features Imaging Treatment Prognosis References 15: Schwannomas Pathology and Histopathology Macroscopic Findings Histological Features Conventional Schwannomas Cellular Schwannomas Plexiform Schwannomas Melanotic Schwannomas Sporadic and Syndromic Schwannomas Syndromic Schwannomas Neurofibromatosis Type 2 (NF2) Schwannomatosis Carney’s Complex Cytogenetics and Molecular Genetics Gene Expression Profiling Prognostic Stratification Molecular Signaling Pathways Molecular Targeted Therapies VEGF ErbB Receptor Family mTOR PDGFR and c-kit Other Targets and Future Outlook References 16: Malignant Peripheral Nerve Sheath Tumors Histopathology Cytogenetics and Molecular Genetics Gene Expression Profiling Prognostic Stratification Treatment of MPNSTS Molecular Signaling Pathways Molecular Targeted Therapies References 17: Meningiomas Histopathology Cytogenetics and Molecular Genetics Grade I Meningiomas High-Grade (Malignant) Meningiomas Gene Expression Profiling Prognostic Stratification Molecular Signaling Pathways Molecular Targeted Therapies References Index
