Molecular Mechanisms of Desensitization to Signal Molecules

Front Matter....Pages N1-XIII
Front Matter....Pages 1-1
Behavioral Adaptation in Prokaryotes....Pages 3-13
Surface Receptor Mediated Activation and Adaptation of Adenylate Cyclase in Dictyostelium discoideum ....Pages 15-24
Adaptation of Dictyostelium Discoideum Cells to Chemotactic Signals....Pages 25-42
Adaptation, Periodic Signaling, and Receptor Modification....Pages 43-62
Front Matter....Pages 63-63
Glucagon Desensitization of Adenylate Cyclase in Hepatocytes: An Action Mediated by a Distinct Population of Glucagon Receptors Coupled to Stimulate Inositol Phospholipid Metabolism....Pages 65-81
Cellular Adaptation to Signal Molecules: Activation and Interaction of Different Signal Transduction Systems....Pages 83-94
Desensitization of the β-Adrenergic Coupled Adenylate Cyclase. The β-Adrenergic Receptor Kinase Phosphorylates Agonist-Occupied Cyclase-Coupled Receptors....Pages 95-115
Structural Microheterogeneity of ß 1 -Adrenoceptors in Turkey Erythrocytes and Their Functional Consequences....Pages 117-127
Adaptive Response of Beta-Adrenergic Sensitive Adenylate Cyclase System....Pages 129-146
Hormone Specific Desensitization of Sertoli Cell Adenylate Cyclase in a Cell-Free System....Pages 147-160
Front Matter....Pages 161-161
Adaptations of Receptor-Dependent Phosphatidylinositol 4,5-Bisphosphate Breakdown....Pages 163-175
Cell Responses to Phosphoinositide-Hydrolysing Receptors: Some Potential Sites of Modulation....Pages 177-195
The Kinase C Substrate Protein B-50 and Feedback Control of Synaptic Signal Transduction....Pages 197-211
Retroinhibition of the Calcium-Phosphatidylinositol Cascade by Diacylglycerol in Thyroid....Pages 213-222
Front Matter....Pages 223-223
Fast Termination and Adaptation Processes in the cGMP Cascade of Visual Transduction....Pages 225-239
Phosphorylation of Rhodopsin Involved in Terminating the Visual Response....Pages 241-254
Front Matter....Pages 255-255
Permeability Control and Desensitization by Nicotinic Acetylcholine Receptors....Pages 257-273
Front Matter....Pages 275-275
Regulation of Leukocyte Responses to Chemoattractants: Role of Receptors, Guanine Nucleotide Regulatory (N) Proteins and Phospholipase C....Pages 277-289
Modulation of Macrophage Oxygen Metabolism....Pages 291-300
Antibody Induced Down Regulation of Membrane Receptors in Human Diseases....Pages 301-317
Front Matter....Pages 319-319
Concluding Remarks....Pages 319-328
Back Matter....Pages 329-338