Molecular Mechanisms for Repair of DNA: Part A

Front Matter....Pages i-xxiv
Front Matter....Pages 1-1
Repairable Damage in DNA: Overview....Pages 3-12
The Nature of the Alkylation Lesion in Mammalian Cells....Pages 13-24
“Excision” of Bases from DNA Methylated by Carcinogens in Vivo and Its Possible Significance in Mutagenesis and Carcinogenesis....Pages 25-28
Alkali-Labile Lesions in DNA from Cells Treated with Methylating Agents, 4-Nitroquinoline- N -oxide, or Ultraviolet Light....Pages 29-30
Apurinic and Apyrimidinic Sites in DNA....Pages 31-38
Maintenance of DNA and Repair of Apurinic Sites....Pages 39-46
DNA Turnover and Strand Breaks in Escherichia coli ....Pages 47-50
Excision-Repair of γ-Ray-Damaged Thymine in Bacterial and Mammalian Systems....Pages 51-59
Formation of Dimers in Ultraviolet-Irradiated DNA....Pages 61-65
An Enzymatic Assay for Pyrimidine Dimers in DNA....Pages 67-69
Front Matter....Pages 71-71
Enzymatic Photoreactivation: Overview....Pages 73-87
Kinetics of Photoreactivation....Pages 89-101
Purifying the Escherichia coli Photoreactivating Enzyme....Pages 103-106
The Human Leukocyte Photoreactivating Enzyme....Pages 107-113
Photorepair of RNA....Pages 115-121
Front Matter....Pages 123-123
Dark Repair in Bacteriophage Systems: Overview....Pages 125-133
Enzymic Mechanism of Excision-Repair in T4-Infected Cells....Pages 135-142
The Repair of Ultraviolet Damage by Phage T4: The Role of the Early Phage Genes....Pages 143-147
Repair of Heteroduplex DNA in Bacteriophage T4....Pages 149-154
Recovery of Phage λ from Ultraviolet Damage....Pages 155-171
Front Matter....Pages 173-173
Enzymology of Excision-Repair in Bacteria: Overview....Pages 175-182
The Escherichia coli UV Endonuclease (Correndonuclease II)....Pages 183-190
Endonuclease II of Escherichia coli ....Pages 191-196
Endonuclease III: An Endonuclease from Escherichia coli That Introduces Single Polynucleotide Chain Scissions in Ultraviolet-Irradiated DNA....Pages 197-200
An Escherichia coli Endonuclease Which Acts on X-Irradiated DNA....Pages 201-204
Substrate Specificity of Micrococcus luteus UV Endonuclease and Its Overlap with DNA Photolyase Activity....Pages 205-208
Two Temperature-Sensitive polA Mutants: An Approach to the Role in Vivo of DNA Polymerase I....Pages 209-211
The Role of DNA Polymerase I in Excision-Repair....Pages 213-218
Involvement of Escherichia coli DNA Polymerase-I-Associated 5′→3′ Exonuclease in Excision-Repair of UV-Damaged DNA....Pages 219-223
Exonuclease VII of Escherichia coli ....Pages 225-234
Enzymatic Repair of UV-Irradiated DNA in Vitro ....Pages 235-243
Repair Replication in Permeabilized Escherichia Coli ....Pages 245-254
Requirement for uvrAB Function for Postirradiation DNA Synthesis in Vitro ....Pages 255-257
DNA Polymerase II-Dependent DNA Synthesis in Toluenized Bacillus subtilis Cells....Pages 259-262
Front Matter....Pages 263-263
Repair by Genetic Recombination in Bacteria: Overview....Pages 265-274
Genetic Exchanges Induced by Structural Damage in Nonreplicating Phage λ DNA....Pages 275-281
The Beginning of an Investigation of the Role of recF in the Pathways of Metabolism of Ultraviolet-Irradiated DNA in Escherichia coli ....Pages 283-291
The Degradation of Duplex DNA by the recBC DNase of Escherichia coli ....Pages 293-299
Analysis of Temperature-Sensitive recB and recC Mutations....Pages 301-306
Recombination and Postreplication Repair....Pages 307-312
Front Matter....Pages 263-263
Ultraviolet-Light-Induced Incorporation of Bromodeoxyuridine into Parental DNA of an Excision-Defective Mutant of Escherichia coli ....Pages 313-316
Distribution of Pyrimidine Dimers During Postreplication Repair in UV-Irradiated Excision-Deficient Cells of Escherichia coli K12....Pages 317-320
Experiments on the Filling of Daughter-Strand Gaps During Postreplication Repair....Pages 321-324
Postreplication Repair Gap Filling in an Escherichia coli Strain Deficient in dnaB Gene Product....Pages 325-329
Involvement of uvrD, exrA , and recB Genes in the Control of the Postreplicational Repair Process....Pages 331-333
Replication and Expression of Constructed Plasmid Chimeras in Transformed Escherichia coli —A Review....Pages 335-344
Front Matter....Pages 345-345
Relationships Among Repair, Mutagenesis, and Survival: Overview....Pages 347-353
SOS Repair Hypothesis: Phenomenology of an Inducible DNA Repair Which is Accompanied by Mutagenesis....Pages 355-367
Thermal Enhancement of Ultraviolet Mutability in a dnaB uvrA Derivative of Escherichia coli B/r: Evidence for Inducible Error-Prone Repair....Pages 369-378
 lexB : A New Gene Governing Radiation Sensitivity and Lysogenic Induction in Escherichia coli K12....Pages 379-382
Indirect Suppression of Radiation Sensitivity of a recA − Strain of Escherichia coli K12....Pages 383-388
The Two-Lesion Hypothesis for UV-Induced Mutation in Relation to Recovery of Capacity for DNA Replication....Pages 389-392
The Effect of Genes Controlling Radiation Sensitivity on Chemical Mutagenesis in Yeast....Pages 393-395
Influence of Repair on the Specificity of Ultraviolet-Induced Reversion of an Ochre Allele of the Structural Gene for Iso-1- cytochrome c ....Pages 397-398
The Role of DNA Polymerase I in Genetic Recombination and Viability of Escherichia coli ....Pages 399-404
The Role of the rec Genes in the Viability of Escherichia coli K12....Pages 405-418
Back Matter....Pages xxv-xliii