Molecular imaging for integrated medical therapy and drug development

Front Matter....Pages I-XXI
Advances in Molecular Imaging....Pages 1-4
Front Matter....Pages 5-5
Hypoxia Imaging for Image-Guided Radiotherapy....Pages 7-18
Molecular Imaging for the Assessment of Tumor Malignancy and Response to Therapy....Pages 19-29
Development of a Prototype 3D PET Scanner Using Semiconductor Detectors and Depth of Interaction Information....Pages 30-41
A New PET Scanner with Semiconductor Detector Reveals Intratumoral Inhomogeneous Cell Activity with High Spatial and Energy Resolution....Pages 42-51
A New Positron Emission Tomography (PET) Scanner with Semiconductor Detectors for Target Volume Delineation and Radiotherapy Treatment Planning in Patients with Nasopharyngeal Carcinoma....Pages 52-59
Initial Performance Measurement of an Integrated PET/SPECT/CT System for Small-Animal Imaging....Pages 60-68
Molecular Imaging of Atherosclerotic Plaque Vulnerability: Comparison between 18 F-FDG and 99m Tc-Annexin A5....Pages 69-77
Quantification of Myocardial Blood Flow Using Rubidium-82 PET....Pages 78-90
Front Matter....Pages 91-91
New Concepts for Molecular and Functional Imaging of the Heart: Implications for Regenerative Treatments....Pages 93-104
Molecular Imaging of Angiogenesis....Pages 105-115
Spontaneous In Vivo Regeneration of the Articular Cartilage Using a Novel Double-Network Hydrogel....Pages 116-125
Bone Marrow Stromal Cell Transplantation for Central Nervous System Disorders: Perspectives for Translational Research and Clinical Application....Pages 126-138
Noninvasive Optical Tracking of Bone Marrow Stromal Cells Transplanted into Rat Cerebral Infarct....Pages 139-144
Thermoreversible Gelation Polymer (TGP) Hydrogel as a Degradable Scaffold for Bone Marrow Stromal Cell Transplantation....Pages 145-151
Beneficial Effects of Bone Marrow Stromal Cell Transplantation on Axonal Regeneration in Injured Spinal Cord....Pages 152-157
Transplanted Bone Marrow Stromal Cells Improve Cognitive Function after Diffuse Axonal Injury in Rats....Pages 158-164
Front Matter....Pages 165-165
Ultra-High Throughput Screening (uHTS) Chemical Genetics to Identify Novel Chronotherapeutics....Pages 167-175
Cell Death and Autophagy....Pages 176-188
Bioluminescent Imaging for Assessing Heterogeneous Cell Functions in the Mammalian Central Circadian Clock....Pages 189-196
Front Matter....Pages 165-165
Early Postnatal Stress and the Serotonergic System in the Brain....Pages 197-206
Neural Circuit Development and Plasticity Shaped by Glutamate Transporters....Pages 207-221
Molecular and Functional Imaging for Drug Development and Elucidation of Disease Mechanisms Using Positron Emission Tomography (PET)....Pages 222-234
Front Matter....Pages 235-235
The Sea as a Source of New Drugs....Pages 237-249
PET/AMS Applications in Drug Development....Pages 250-259
Functional and Structural Analysis Reveals Dual Function on C-Terminal α Helix of Alg13 Protein....Pages 260-280
Discovery of a First-in-Class Drug, a Prostaglandin D 2 Antagonist, for the Treatment of Allergic Diseases....Pages 281-287
Towards Developing a Golgi Simulator: Microfluidic Device Enabling Synthesis of a Tetrasaccharide....Pages 288-293
An Efficient Strategy for the Exploration of Specific Inhibitors of Sialyltransferases....Pages 294-301
Back Matter....Pages 302-303