Molecular Design and Modeling: Concepts and Applications Part B: Antibodies and Antigens, Nucleic Acids, Polysaccharides, and Drugs

Content: 
Contributors to volume 203
Pages ix-xi

Preface
Page xiii
John J. Langone

Volumes in series
Pages xv-xxxi

[1] Modeling of antibody combining sites Original Research Article
Pages 3-21
Eduardo A. Padlan, Elvin A. Kabat

[2] Computer modeling of combining site structure of anti-hapten monoclonal antibodies Original Research Article
Pages 21-45
Michael B. Bolger, Mark A. Sherman

[3] Protein engineering of single-chain Fv analogs and fusion proteins Original Research Article
Pages 46-52,IN1,53-88
James S. Huston, Meredith Mudgett-Hunter, Mei-Sheng Tai, John McCartney, Frederick Warren, Edgar Haber, Hermann Oppermann

[4] Construction of single-chain Fv derivatives of monoclonal antibodies and their production in Escherichia coli Original Research Article
Pages 88-98
Syd Johnson, Robert E. Bird

[5] Humanization of monoclonal antibodies Original Research Article
Pages 99-121
Detlef GГјssow, Gerhard Seemann

[6] Molecular modeling of antibody combining sites Original Research Article
Pages 121-153
Andrew C.R. Martin, Janet C. Cheetham, Anthony R. Rees

[7] X-ray crystallographic analysis of free and antigen-complexed Fab fragments to investigate structural basis of immune recognition Original Research Article
Pages 153-176
Ian A. Wilson, James M. Rini, Daved H. Fremont, Gail G. Fieser, Enrico A. Stura

[8] Predicting location of continuous epitopes in proteins from their primary structures Original Research Article
Pages 176-201
J.L. Pellequer, E. Westhof, M.H.V. Van Regenmortel

[9] Use of two-dimensional 1H nuclear magnetic resonance to study high-affinity antibody-peptide interactions Original Research Article
Pages 202-228
Janet C. Cheetham, Christina Redfield, Robert E. Griest, Daniel P. Raleigh, Christopher M. Dobson, Anthony R. Rees

[10] Nuclear magnetic resonance for studying peptide — Antibody complexes by transferred nuclear overhauser effect difference spectroscopy Original Research Article
Pages 228-241
Jacob Anglister, Fred Naider

[11] Isotope-edited nuclear magnetic resonance studies of fab-peptide complexes Original Research Article
Pages 241-261
P. Tsang, M. Rance, P.E. Wright

[12] Reductive methylation and carbon-13 nuclear magnetic resonance in structure—function studies of Fc fragment and its subfragments Original Research Article
Pages 261-274
Joyce E. Jentoft

[13] Immunoelectron microscopy and image processing for epitope mapping Original Research Article
Pages 274-295
Nicolas Boisset, Jean N. Lamy

[14] Characterization of antigenic structures by mapping on resin-bound epitope analogs Original Research Article
Pages 295-300
Wan-Jr Syu, Lawrence Kahan

[15] Epitope mapping of allergens for rapid localization of continuous allergenic determinants Original Research Article
Pages 301-311
Bradley J. Walsh, Merlin E. Howden

[16] Design and production of bispecific monoclonal antibodies by hybrid hybridomas for use in immunoassay Original Research Article
Pages 312-327
Miyoko Takahashi, Steven A. Fuller, Scott Winston

[17] Catalytic antibodies Original Research Article
Pages 327-351
Kevan M. Shokat, Peter G. Schultz

[18] Antibody catalysis of concerted, carbonо—ёcarbon bond-forming reactions Original Research Article
Pages 352-369
Donald Hilvert, Kenneth W. Hill

[19] Selection of T cell epitopes and vaccine engineering Original Research Article
Pages 370-386
Francesco Sinigaglia, Paola Romagnoli, Maria Guttinger, Bela Takacs, J.Richard L. Pink

[20] Design, construction, and characterization of poliovirus antigen chimeras Original Research Article
Pages 386-400
David J. Evans, Jeffrey W. Almond

[21] Computer simulation of DNA supercoiling Original Research Article
Pages 403-432
Wilma K. Olson, Peisen Zhang

[22] Molecular modeling to study DNA intercalation by anti-tumor drugs Original Research Article
Pages 433-458
Stephen Neidle, Terence C. Jenkins

[23] Molecular modeling in mutagenesis and carcinogenesis Original Research Article
Pages 458-476
Edward L. Loechler

[24] In Situ hybridization and immunodetection techniques for simultaneous localization of messenger RNAs and protein epitopes in tissue sections and cultured cells Original Research Article
Pages 476-484
Juha Peltonen, Sirkku Jaakkola, Jouni Uitto

[25] Transfer RNA with double identity for in Vitro kinetic modeling of transfer RNA identity in Vivo Original Research Article
Pages 485-500
Paul Schimmel, Jonathan J. Burbaum

[26] Design of simplified ribonuclease P RNA by phylogenetic comparison Original Research Article
Pages 500-510
Norman R. Pace, David S. Waugh

[27] Molecular modeling and electron diffraction of polysaccharides Original Research Article
Pages 510-556
Serge PГ©rez

[28] Molecular design and modeling of protein—heparin interactions Original Research Article
Pages 556-583
Alan D. Cardin, David A. Demeter, Herschel J.R. Weintraub, Richard L. Jackson

[29] Computer-assisted rational drug design Original Research Article
Pages 587-613
Yvonne Connolly Martin

[30] Pattern recognition methods in rational drug design Original Research Article
Pages 613-638
David J. Livingstone

[31] Molecular electrostatic potentials for characterizing drug-biosystem interactions Original Research Article
Pages 638-677
Pierre-Alain Carrupt, Nabil El Tayar, Anders KarlГ©n, Bernard Testa

[32] Pharmacophore for nicotinic agonists Original Research Article
Pages 677-690,IN3-IN6,691-693
T.M. Gund, C.E. Spivak

[33] Related chapters published in previous volumes of Methods in Enzymology
Pages 697-701

Author index
Pages 703-741

Subject index
Pages 743-764