Molecular Biology of the Lung: Volume I: Emphysema and Infection

Front Matter....Pages I-VIII
Application of Transgenic and Gene-Targeted Mice to Dissect Mechanisms of Lung Disease....Pages 1-15
Front Matter....Pages 17-17
Models of Genetic Emphysema: The C57B1/6J Mice and their Mutants: Tight-Skin, Pallid and Beige....Pages 19-36
α 1 -Antitrypsin Deficiency....Pages 37-53
Recombinant SLPI: Emphysema and Asthma....Pages 55-67
Elastase Inhibitors in the Lung: Expression and Functional Relationships....Pages 69-94
Regulation of Neutrophil Proteinases....Pages 95-112
Control of Connective Tissue Genes....Pages 113-130
Front Matter....Pages 131-131
Genetic Models of Bacterial Lung Infection....Pages 133-147
Genetics of Bacteria: Role in Pathogenesis of Infection of the Respiratory Tract....Pages 149-162
Polymerase Chain Reaction in the Diagnosis of Respiratory Tract Infections....Pages 163-180
Cystic Fibrosis....Pages 181-198
Respiratory Bacterial Infections in Patients with Cystic Fibrosis: Pathogenicity and Implications for Serine Proteinase Inhibitor Therapy....Pages 199-214
Back Matter....Pages 215-216