Molecular Biology of the Arterial Wall

Front Matter....Pages I-IX
Front Matter....Pages 1-1
LDL Receptor Mutations in Patients with Familial Hypercholesterolemia....Pages 2-4
Lipoprotein Receptors and Their Ligands: Structure and Function of Apoproteins E and B....Pages 5-7
The Role of HDL in Cholesterol Homeostasis of Macrophages and Reversed Cholesterol Transport....Pages 8-9
Lipoproteins, Macrophages and Atherosclerosis....Pages 10-12
Arterial Lipoprotein Metabolism: Site-Specific Differences Related to Susceptibility to Atherosclerotic Lesions....Pages 13-16
Lipoprotein disposition by the liver: A concerted action of various cell types....Pages 17-18
The Macrophage and Endothelial Cell Scavenger Receptor....Pages 19-21
Characterization of the Hepatic Scavenger Receptor....Pages 22-24
Front Matter....Pages 25-25
The Role of PDGF in Health and Disease....Pages 26-29
Role of PDGF-like growth factors in autocrine stimulation of cell growth....Pages 30-31
The PDGF Receptor As A Mediator of Mitogenesis....Pages 32-35
α- and β-Heparin Binding Growth Factors: Chemistry and Biology of Acidic and Basic Fibroblast Growth Factors....Pages 36-40
Structure, Homologies and Activities of Acidic Fibroblast Growth Factor....Pages 41-43
Endothelial Cell Growth Factor and Its Receptor....Pages 44-46
Front Matter....Pages 47-47
Intracellular Transport Of Human Class I Antigens And An Adenoviral Glycoprotein....Pages 48-50
Molecular Mechanisms of Endocytic Sorting....Pages 51-55
Characterisation of a fusion event from the endocytic pathway....Pages 56-58
Membrane Boundaries Involved in the Selective Trafficking of Cell Surface Receptors....Pages 59-60
The Molecular Basis of Human Cellular Iron Metabolism....Pages 61-64
Front Matter....Pages 65-65
Molecular Features Involved in Cell Surface Receptor Function and Their Role in Oncogenesis....Pages 66-68
Front Matter....Pages 65-65
Transforming Activity of the fms Oncogene (CSF-1 Receptor)....Pages 69-70
Functional and Structural Analysis of the v-src and c-src Genes....Pages 71-72
Ras Oncogenes and Cell Transformation....Pages 73-75
Cis Regulatory Control of mos Oncogene Expression....Pages 76-80
Analysis of the Function of the fos Oncogene Product....Pages 81-83
Cooperative Interactions Involving Cellular and Viral Oncogenes in the Development of Malignant Tumors....Pages 84-84
Front Matter....Pages 85-85
The Motor of Leukocytes and Platelets: 1986....Pages 86-87
Heterogeneity of Murine and Human Fc γ Receptors....Pages 88-90
Complement Receptors....Pages 91-93
Cachectin: A Macrophage Protein that Induces a Catabolic State in Infected Animals....Pages 94-94
The role of cytosolic free calcium, (Ca 2+ ) i , and phosphoinositides as intracellular signals....Pages 95-96
The macrophage-blood interface: Cell localisation and recruitment in bone marrow, liver and brain....Pages 97-100
Normal and Neoplastic Early Lymphocyte Maturation....Pages 101-101
Molecular Regulation of Complement Gene Expression....Pages 102-103
Front Matter....Pages 105-105
The role of GTP-binding proteins in coupling prostaglandin and leukotriene receptors to intracellular second messenger systems....Pages 106-109
Regulation of vascular tone by prostaglandins and endothelium-derived relaxing factor....Pages 110-114
Endogenous Cysteinyl Leukotrienes as Mediators in Endotoxin Shock and Tissue Trauma....Pages 115-116
Source and Mechanism of Release of Arachidonic Acid in Blood Platelets....Pages 117-118
Eicosanoids and the Pulmonary Circulation....Pages 119-122
Regulation of the production (leukotriene A 4 hydrolase) and the action (leukotriene B 4 receptor sites) of leukotriene B 4 ....Pages 123-125
Front Matter....Pages 105-105
Enzymic Synthesis and Degradation of Prostaglandin D 2 ....Pages 126-128
Receptor-Dependent Regulation of Human Polymorphonuclear Leukocyte Responses to Leukotrienes....Pages 129-131
Leukotriene C 4 -binding Proteins....Pages 132-133
Leukotriene C metabolizing enzymes....Pages 134-137
Front Matter....Pages 139-139
The Fibrinolytic System of Cultured Bovine Aortic Endothelial Cells....Pages 140-144
Tumor Necrosis Factor/Cachectin and the Modulation of Endothelial Cell Coagulant Properties....Pages 145-147
Membrane glycoproteins of endothelial cells and platelets....Pages 148-150
The Molecular Biology of Endothelial Cell von Willebrand Factor....Pages 151-154
Induction and Regulation of Endothelial Gene Expression....Pages 155-158
Endothelium-Vascular Smooth Muscle Interactions in Culture....Pages 159-162
Endothelial Morphogenesis....Pages 163-165
Closing Remarks....Pages 166-166
Final Word....Pages 167-167
Back Matter....Pages 168-169