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دانلود کتاب Molecular Biology of Hand-Foot-Mouth Diseases
دانلود کتاب زیست شناسی مولکولی بیماری های دست، پا و دهان
مشخصات کتاب
Molecular Biology of Hand-Foot-Mouth Diseases
ویرایش: نویسندگان: Xingli Xu (editor), Yanchun Che (editor), Qihan Li (editor) سری: ISBN (شابک) : 9819996589, 9789819996582 ناشر: Springer سال نشر: 2024 تعداد صفحات: 181 [179] زبان: English فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) حجم فایل: 6 Mb
قیمت کتاب (تومان) : 59,000
در صورت تبدیل فایل کتاب Molecular Biology of Hand-Foot-Mouth Diseases به فرمت های PDF، EPUB، AZW3، MOBI و یا DJVU می توانید به پشتیبان اطلاع دهید تا فایل مورد نظر را تبدیل نمایند.
توجه داشته باشید کتاب زیست شناسی مولکولی بیماری های دست، پا و دهان نسخه زبان اصلی می باشد و کتاب ترجمه شده به فارسی نمی باشد. وبسایت اینترنشنال لایبرری ارائه دهنده کتاب های زبان اصلی می باشد و هیچ گونه کتاب ترجمه شده یا نوشته شده به فارسی را ارائه نمی دهد.
توضیحاتی در مورد کتاب زیست شناسی مولکولی بیماری های دست، پا و دهان
هدف این کتاب گردآوری آخرین اطلاعات علمی در مورد بیماری دست، پا و دهان (HFMD) شامل اپیدمیولوژی، علت شناسی، آسیب شناسی، پاسخ ایمنی و ساخت واکسن است. جالب اینجاست که نویسندگان تجربه تحقیقاتی خود را به اشتراک گذاشتند و بینش‌های متمایزی را در مورد پاتوژنز HFMD و توسعه واکسن ارائه کردند. مخاطب مورد نظر شامل محققان دانشگاه، دانشجویان فارغ التحصیل و مهندسان واکسن به خوبی تعریف شده است. این کتاب به عنوان منبعی است که نه تنها دانش فعلی را ارائه می دهد، بلکه پتانسیل الهام بخشیدن به تحقیقات بیشتر در درک پاتوژنز ایمنی و پیشرفت توسعه واکسن برای HFMD را دارد.
توضیحاتی درمورد کتاب به خارجی
This book aims to compile the latest scientific information on hand, foot, and mouth disease (HFMD), including its epidemiology, etiology, pathology, immune response and vaccine development. Interestingly, the authors shared their own research experience and offered distinctive insights into the pathogenesis of HFMD and vaccine development. The intended audience, including university researchers, graduate students, and vaccine engineers, is well defined. The book is positioned as a resource that not only presents current knowledge but also has the potential to inspire further research in understanding immune pathogenesis and advancing vaccine development for HFMD.
فهرست مطالب
Preface Contents Editors and Contributors About the Editors Contributors Chapter 1: Epidemics of Hand, Foot, and Mouth Disease 1 Introduction 2 HFMD Epidemiology The 1970s–1980s Europe Asia Oceania The Americas 1990–1999 Europe Asia Oceania The Americas 2000–2015 Europe Asia Oceania America 2016 to the Present Europe Asia The Americas 3 Variety of Circulating Viruses EV-A71 is a Major Pathogen Leading to Severe and Fatal Cases HFMD Pathogens Tend to Exhibit Great Variability 4 HFMD Epidemic Cycle References Chapter 2: Etiology of HFMD 1 Enteroviruses (EVs) Discovery of EVs CV-A CV-B ECHO Viruses Structure and Physical and Chemical Features of EVs Evolution of EVs Classifications of EVs 2 EV-Associated Diseases Hand, Foot, and Mouth Disease Poliomyelitis Other Diseases 3 Common Pathogens of HFMD EV-A71 Discovery of EV-A71 Structure and Genomic Features of EV-A71 Genogroups and the Evolution of EV-A71 EV-A71-Associated Diseases CV-A16 Discovery of CV-A16 Structural and Genomic Characteristics of CV-A16 Genotypes of CV-A16 CV-A16-Associated Diseases EV-A71 and CV-A16 Cocirculation Other Enteroviruses 4 Rapid Diagnosis and Genotyping of EV Infection References Chapter 3: Mechanisms Underlying HFMD Clinical Pathology in Children 1 Clinical Manifestations of HFMD Typical Mild HFMD in Children Atypical HFMD in Children Fatal HFMD in Children 2 HFMD Pathogenesis Biological Features of Enteroviruses and HFMD Development Etiology of Enterovirus Infection Unique EV-A71 Structure and Related Pathogenicity Host Gene Susceptibility and HFMD OAS Genes HLA Gene Receptors Involved in Viral Interactions with Host Cells Host Immune Response and HFMD Viral Infection and Innate Immune Escape HFMD and the Inflammatory Response Oxidative Stress (OS) Signaling NF-kB Signaling Epidermal Growth Factor Receptor (EGFR) Signaling Mitogen-Activated Protein Kinase (MAPK) Signaling Phosphatidylinositol 3-Kinase (PI3K) Signaling Calcium (Ca2+)-Dependent Signaling Cytokines Associated with the Development of HFMD Viral Infection and Host Pathological Injury Autophagy Apoptosis 3 Pathogenesis of HFMD-Associated Disease Pathogenesis of HFMD-Associated Skin Rash and Blisters Pathogenesis of HFMD-Complicated CNS Disorders Direct Pathogenicity Induced by Viral Infection Immune Injury Inflammatory Injury Pathogenesis of HFMD-Complicated Neurogenic PE Pathogenesis of HFMD-Complicated Injury of Other Organs Pathogenesis of HFMD-Complicated Myocardium Injury Pathogenesis of HFMD-Complicated Gastrointestinal Injury Pathogenesis of HFMD-Complicated Acute Kidney Injury Pathogenesis of HFMD-Complicated Acute Liver Injury 4 Conclusion References Chapter 4: The Characteristics of EV-A71-CV-A16 Infection and Interaction with a Host 1 Preface 2 Host Characteristics of EV-A71-CV-A16 Infection Characteristics of EV-A71 Infection Characteristics of CV-A16 Infection 3 Characteristics of the Immune Response to EV-A71-CV-A16 Infection Characteristics of the EV-A71-CV-A16 Innate Immune Response EV-A71 Infection and Host Cell Pattern Recognition Receptor (PRR)-Related Signaling Pathways EV-A71 Infection- and Injury-Associated Molecules Characteristics of the EV-A71-CV-A16 Adaptive Immune Response 4 EV-A71-CV-A16 Interacts with the Host The Mechanism by Which EV-A71-CV-A16 Escapes the Innate Immune Response Cessation of Host Protein Synthesis Interference with PRR Recognition Interference with Molecules Involved in Innate Immune Signaling Pathways Interference with Interferon-Mediated Signaling MicroRNA (miRNA) Interference Regulation EV-A71-CV-A16 Escapes Adaptive Immunity Relationship Between EVs and Activation of the Host Immune Response 5 Conclusion References Chapter 5: Pathogen–Host Interaction and Its Associated Molecular Mechanism in HFMD Pathology and Immunology 1 Introduction 2 Etiological Significances of the Original Structural Characteristics of HFMD-Causing Viruses Significance of the Structural Dynamics of Picornaviruses Structural Characteristics of the Major Pathogens Causing HFMD and Their Host Receptors 3 Physiological and Pathological Significance of the Major Pathogenic Viruses Binding to Receptors Significance of the Physiological Characteristics of the Interaction Between Receptors and Different Viruses The Physiological Significance of Virus Binding to Receptors The Signal Transduction After Virus Binding to Receptors Molecular Biology Analysis of EV-A71/CV-A16 Infection of Cells Molecular Biology Analysis of the Effects of EV-A71 and CV-A16 on Histopathology Analysis of the Effects of EV-A71 and CV-A16 Interactions with the Immune System 4 Immunological Study of a Multivalent Vaccine for HFMD Caused by Two or More Pathogens Study on the Immunological Mechanisms of Different Types of HFMD Vaccines Theoretical and Technical Analysis for the Research and Development of Multivalent HFMD Vaccines References Chapter 6: Research and Development of HFMD Vaccines 1 Introduction 2 Inactivated Vaccines Monovalent Inactivated Vaccines EV-A71 Monovalent Inactivated Vaccine CV-A16 Monovalent Inactivated Vaccine CV-A10 Monovalent Inactivated Vaccine Multivalent Inactivated Vaccines EV-A71/CV-A16 Bivalent Inactivated Vaccine CV-A6/CV-A10 Bivalent Inactivated Vaccine Trivalent Inactivated Vaccines CV-A6, CV-A10, and CV-A16 CV-A6, EV-A71, and CV-A16 Trivalent Inactivated Vaccines 3 Live Attenuated Vaccines 4 Virus-Like Particle Vaccines Monovalent VLP Vaccines CV-A5 Monovalent VLP Vaccine CV-A6 Monovalent VLP Vaccine CV-A10 Monovalent VLP Vaccine CV-A16 Monovalent VLP Vaccine EV-A71 Monovalent VLP Vaccine Multivalent VLP Vaccines EV-A71/Nov Bivalent VLP Vaccine CV-A6/CV-A10/CV-A16/EV-A71 Tetravalent VLP Vaccine 5 Subunit Vaccines 6 Viral Vector Vaccines 7 DNA Vaccines 8 RNA Vaccines 9 Conclusion References
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