Molecular Biology of B Cells

Content: 
Front Matter, Page iii
Copyright, Page iv
Dedication, Page v
Preface, Pages xvii-xviii, Frederick W. Alt, Tasuku Honjo, Radbruch Andreas, Michael Reth
Contributors, Pages xix-xxii, Frederick W. Alt, Radbruch Andreas, Nasim A. Begum, Michael C. Carroll, Andrea Cerutti, Richard Chahwan, Tsutomu Chiba, Max D. Cooper, Riccardo Dalla-Favera, Van Duc Dang, Sabyasachi Das, Betty Diamond, Anne Durandy, Sidonia Fagarasan, Ann J. Feeney, Marc Feldmann, Simon Fillatreau, Alain Fischer, Jennifer L. Gommerman, Carl S. Goodyear, James Hagman,  et al.
Chapter 1 - The Structure and Regulation of the Immunoglobulin Loci, Pages 1-11, Joseph S. Lucas, Cornelis Murre, Ann J. Feeney, Roy Riblet
Chapter 2 - The Mechanism of V(D)J Recombination, Pages 13-34, Alicia J. Little, Adam Matthews, Marjorie Oettinger, David B. Roth, David G. Schatz
Chapter 3 - Transcriptional Regulation of Early B Cell Development, Pages 35-53, James Hagman
Chapter 4 - Relationships among B Cell Populations Revealed by Global Gene Analysis, Pages 55-63, Yan Zhou, Byoung-Gon Moon, Susan A. Shinton, Kyoko Hayakawa, Richard R. Hardy
Chapter 5 - Roles of MicroRNAs in B Lymphocyte Physiology and Oncogenesis, Pages 65-73, Stefan A. Muljo, Klaus Rajewsky
Chapter 6 - Proliferation and Differentiation Programs of Developing B Cells, Pages 75-97, Markus Werner, Hassan Jumaa
Chapter 7 - Development and Function of B Cell Subsets, Pages 99-119, Andre M. Vale, John F. Kearney, Alberto Nobrega, Harry W. Schroeder
Chapter 8 - B Cells and Antibodies in Jawless Vertebrates, Pages 121-132, Brantley R. Herrin, Masayuki Hirano, Jianxu Li, Sabyasachi Das, Yoichi Sutoh, Max D. Cooper
Chapter 9 - The Origin of V(D)J Diversification, Pages 133-149, Ellen Hsu, Susanna M. Lewis
Chapter 10 - Structure and Signaling Function of the B-Cell Antigen Receptor and Its Coreceptors, Pages 151-170, Michael Reth, Lars Nitschke, Masaki Hikida, Tomohiro Kurosaki
Chapter 11 - Fc and Complement Receptors, Pages 171-186, Jeffrey V. Ravetch, Falk Nimmerjahn, Michael C. Carroll
Chapter 12 - B Cell Localization and Migration in Health and Disease, Pages 187-214, Anja E. Hauser, Uta E. Höpken
Chapter 13 - B Cells as Regulators, Pages 215-225, Ping Shen, Ellen Hilgenberg, Andreia C. Lino, Van Duc Dang, Stefanie Ries, Imme Sakwa, Simon Fillatreau
Chapter 14 - B Cell Memory and Plasma Cell Development, Pages 227-249
Chapter 15 - The Role of the BAFF and Lymphotoxin Pathways in B Cell Biology, Pages 251-276, Fabienne Mackay, Jennifer L. Gommerman
Chapter 16 - The Mucosal Immune System: Host–Bacteria Interaction and Regulation of Immunoglobulin A Synthesis, Pages 277-291, Sidonia Fagarasan, Giuliana Magri, Andrea Cerutti
Chapter 17 - Gut Microbiota and Their Regulation, Pages 293-304, Frederick W. Alt, Duane R. Wesemann
Chapter 18 - Molecular Mechanisms of AID Function, Pages 305-344, Nasim A. Begum, Hitoshi Nagaoka, Maki Kobayashi, Tasuku Honjo
Chapter 19 - The Mechanism of IgH Class Switch Recombination, Pages 345-362, Fei-Long Meng, Frederick W. Alt, Ming Tian
Chapter 20 - Somatic Hypermutation: The Molecular Mechanisms Underlying the Production of Effective High-Affinity Antibodies, Pages 363-388, Alberto Martin, Richard Chahwan, Jahan Yar Parsa, Matthew D. Scharff
Chapter 21 - Aberrant AID Expression by Pathogen Infection, Pages 389-397, Atsushi Takai, Hiroyuki Marusawa, Tsutomu Chiba
Chapter 22 - Molecular Pathogenesis of B Cell Lymphomas, Pages 399-416, Riccardo Dalla-Favera, Laura Pasqualucci
Chapter 23 - B Cells Producing Pathogenic Autoantibodies, Pages 417-439, Yong-Rui Zou, Betty Diamond
Chapter 24 - The Cellular and Molecular Biology of HIV-1 Broadly Neutralizing Antibodies, Pages 441-461, Barton F. Haynes, Kevin O. Saunders, Garnett Kelsoe, John R. Mascola, Gary J. Nabel
Chapter 25 - Immune Deficiencies Caused by B Cell Defects, Pages 463-479, Anne Durandy, Sven Kracker, Alain Fischer
Chapter 26 - IMGT® Immunoglobulin Repertoire Analysis and Antibody Humanization, Pages 481-514, Marie-Paule Lefranc
Chapter 27 - Anti-Interleukin-6 Receptor Antibody Therapy Against Autoimmune Inflammatory Diseases, Pages 515-525, Toshio Tanaka, Masashi Narazaki, Tadamitsu Kishimoto
Chapter 28 - Targeting the IL-17/IL-23 Axis in Chronic Inflammatory Immune-Mediated Diseases, Pages 527-539, Alexander Tsoukas, Carl S. Goodyear, Iain B. McInnes
Chapter 29 - Discovery and Development of Anti-TNF Therapy: Pillar of a Therapeutic Revolution, Pages 541-547, Marc Feldmann
Index, Pages 549-563