Molecular Biology for Oncologists

Content: 
Front Matter....Pages i-xiv
Front Matter....Pages 1-1
What are cancer genes and how do they upset cell behaviour?....Pages 3-15
Mechanisms of activation and inactivation of dominant oncogenes and tumour suppressor genes....Pages 16-26
Hereditary predisposition and gene discovery....Pages 27-37
Chromosomal translocations in cancer....Pages 38-44
Signal transduction and cancer....Pages 45-62
G proteins, Ras and cancer....Pages 63-74
Cell cycle control and cancer....Pages 75-82
Human papillomaviruses and cancer of the cervix....Pages 83-91
The p53 gene in human cancer....Pages 92-102
Cell adhesion, motility and cancer....Pages 103-111
Differentiation and cancer....Pages 112-121
Multistage carcinogenesis....Pages 122-133
Genomic instability and cancer....Pages 134-151
Front Matter....Pages 153-153
Inherited predispositions to cancer: opportunities for genetic counselling....Pages 155-165
Molecular basis of radiation sensitivity....Pages 166-175
How do cells repair DNA damage caused by ionizing radiation?....Pages 176-184
Chemotherapeutic drug-induced DNA damage and repair....Pages 185-197
Molecular basis of drug resistance....Pages 198-207
Drug discovery and cancer genetics....Pages 208-216
The molecular biology of endocrine responsiveness in breast cancer....Pages 217-229
Front Matter....Pages 153-153
Apoptosis as a therapeutic target....Pages 230-239
Tumour angiogenesis as a therapeutic target....Pages 240-249
Antibody technology has been transformed....Pages 250-260
Current and future aspects of gene therapy for cancer....Pages 261-268
Directed enzyme prodrug therapies: ADEPT and GDEPT....Pages 269-274
Oligonucleotide therapies....Pages 275-292
Front Matter....Pages 293-293
Introduction to gene structure and expression....Pages 295-302
Chromatin structure and nuclear function....Pages 303-315
The PCR revolution....Pages 316-321
Techniques of molecular biology....Pages 322-331
Back Matter....Pages 332-353