Molecular Biology and Physiology of Insulin and Insulin-Like Growth Factors

Front Matter....Pages i-xiii
Structural and Regulatory Aspects of the Human Genes Encoding IGF-I and -II....Pages 1-14
Structural and Functional Characterization of IGF-I RNA 3’ Variants....Pages 15-21
Characterization of the Biological Activity of IGF I Analogs with Reduced Affinity for IGF Receptors and Binding Proteins....Pages 23-30
Insulin-Like Growth Factor II: Complexity of Biosynthesis and Receptor Binding....Pages 31-44
Development of a Specific Radioimmuno Assay for E Domain Containing Forms of Insulin-Like Growth Factor II....Pages 45-56
The Role of the IGFs in Myogenic Differentiation....Pages 57-76
Extinction of Human Insulin-Like Growth Factor II Expression in Somatic Cell Hybrids....Pages 77-83
The Growth Hormone-Insulin-Like Growth Factor I Axis: Studies in Man during Growth....Pages 85-96
Recombinant Human Insulin-Like Growth Factor I: Effects in Normal Subjects and Implications for Use in Patients....Pages 97-104
Single sc Administration of Insulin-Like Growth Factor I (IGF-I) in Normal Men....Pages 105-112
Insulin-Like Growth Factor Binding Protein Control Secretion and Mechanisms of Action....Pages 113-123
Regulation and Actions of Insulin-Like Growth Factor Binding Protein-3....Pages 125-135
Regulation of Gene Expression of Rat Insulin-Like Growth Factor Binding Proteins 1 and 2....Pages 137-148
Hormonal Regulation of Insulin-Like Growth Factor Binding Protein-1 Expression in the Rat....Pages 149-160
Cerebrospinal IGF Binding Proteins : Isolation and Characterization....Pages 161-170
The Effect of Quantity and Nutritional Quality of Dietary Proteins on Plasma Concentration of Insulin-Like Growth Factor Binding Proteins (IGFBP) and the Saturability of IGFBP with Endogenous IGF-I....Pages 171-178
Presence of Insulin-Like Growth Factors and Their Binding Proteins in Rat Milk....Pages 179-186
Molecular Heterogeneity of Insulin Receptors in Rat Tissues....Pages 187-195
Mutations in the Insulin Receptor Gene in Patients with Genetic Syndromes of Insulin Resistance....Pages 197-213
Role of Receptor Internalization in Insulin Signalling....Pages 215-225
Endogenous Substrates of the Insulin Receptor: Studies with Cells Expressing Wild-Type and Mutant Receptors....Pages 227-238
Molecular Mechanisms Involved in the Antilipolytic Action of Insulin: Phosphorylation and Activation of a Particulate Adipocyte cAMP Phosphodiesterase....Pages 239-248
Regulation of the Glucose Transporter in Animal Models of Diabetes....Pages 249-262
Regulation of Insulin-Like Growth Factor I Receptor Gene Expression in Normal and Pathological States....Pages 263-272
IGF-I Mediated Recruitment of Glucose Transporters from Intracellular Membranes to Plasma Membranes in L6 Muscle Cells....Pages 273-288
Insulin-Like Growth Factors and Their Receptors in Muscle Development....Pages 289-295
Insulin-Like Growth Factor Receptors in Testicular Vascular Tissue from Normal and Diabetic Rats....Pages 297-309
Reciprocal Modulation of Binding of Lysosomal Enzymes and Insulin-Like Growth Factor-II (IGF-II) to the Mannose 6- Phosphate/IGF-II Receptor....Pages 311-324
Expression of IGF-II, the IGF-II/Mannose-6-Phosphate Receptor and IGFBP-2 During Rat Embryogenesis....Pages 325-333
Early Events in the Hormonal Regulation of Glial Gene Expression: Early Response Genes....Pages 335-350
Trophic Actions of IGF-I, IGF-II and Insulin on Cholinergic and Dopaminergic Brain Neurons....Pages 351-360
Second Messengers Mediating Gene Expression Essential to Neurite Formation Directed by Insulin and Insulin-Like Growth Factors....Pages 361-378
Regulation of Protein Phosphorylation by Insulin and Insulin-Like Growth Factors in Cultured Fetal Neurons....Pages 379-384
A Review of Insulin/Insulin-Like Peptide in the Central Nervous System....Pages 385-396
Glucose Transporters in Central Nervous System Glucose Homeostasis....Pages 397-404
The Mammalian Brain Glucose Transport System....Pages 405-417
Regulation and Physiological Function of Insulin-Like Growth Factors in the Central Nervous System....Pages 419-430
IGF-I mRNA Localization in Trigeminal and Sympathetic Nerve Target Zones During Rat Embryonic Development....Pages 431-437
Neuroactive Products of IGF-I and IGF-2 Gene Expression in the CNS....Pages 439-448
Distribution of Insulin-Like Growth Factor 1 (IGF-1) and 2 (IGF-2) Receptors in the Hippocampal Formation of Rats and Mice....Pages 449-458
Localization of Insulin and Type 1 IGF Receptors in Rat Brain by in Vitro Autoradiography and in Situ Hybridization....Pages 459-470
Insulin-Like Growth Factor Binding Proteins in the Nervous System....Pages 471-482
Binding of [ 125 I]-Insulin-Like Growth Factor-1 (IGF-1) in Brains of Alzheimer’s and Alcoholic Patients....Pages 483-492
Insulin-Like Growth Factor I: A Possible Modulator of Intercellular Communication in the Brain....Pages 493-505
Back Matter....Pages 507-528