Molecular Biology and Pathogenesis of Coronaviruses

Front Matter....Pages i-xiii
Biochemistry of Coronaviruses 1983....Pages 1-10
Organization of the IBV Genome....Pages 11-23
Proteolytic Cleavage of Peplomeric Glycoprotein E2 of MHV Yields Two 90K Subunits and Activates Cell Fusion....Pages 25-35
Coronavirus Maturation....Pages 37-52
 In Vitro Assembly of the Murine Coronavirus Membrane Protein E1....Pages 53-64
Characterization of Viral Proteins Synthesized in 229E Infected Cells and Effect(s) of Inhibition of Glycosylation and Glycoprotein Transport....Pages 65-77
Defective Replication of Porcine Transmissible Gastroenteritis Virus in a Continuous Cell Line....Pages 79-93
Structural Characterization of IBV Glycoproteins....Pages 95-108
Use of Monoclonal Antibodies to Assess Antigenic Relationships of Avian Infectious Bronchitis Virus Serotypes in the United States....Pages 109-113
Monoclonal Antibodies to the Three Classes of Mouse Hepatitis Virus Strain A59 Proteins....Pages 115-116
Antigenic and Polypeptide Structure of Bovine Enteric Coronavirus as Defined by Monoclonal Antibodies....Pages 117-132
Plaque Assay, Polypeptide Composition and Immunochemistry of Feline Infectious Peritonitis Virus and Feline Enteric Coronavirus Isolates....Pages 133-147
Assembly of 229E Virions in Human Embryonic Lung Fibroblasts and Effects of Inhibition of Glycosylation and Glycoprotein Transport on this Process....Pages 149-150
Amphotericin Inhibits Coronavirus SD, SK and A59 Growth....Pages 151-152
Electron Lucent Structures Induced by Coronaviruses....Pages 153-154
Cloning and Sequencing the Nucleocapsid and E1 Genes of Coronavirus....Pages 155-162
Nucleotide Sequencing of Mouse Hepatitis Virus Strain JHM Messenger RNA 7....Pages 163-171
Transcription Strategy of Coronaviruses: Fusion of Non-Contiguous Sequences During mRNA Synthesis....Pages 173-186
Studies on the Mechanism of RNA Synthesis of a Murine Coronavirus....Pages 187-200
Glycoprotein E1 of MHV-A59: Structure of the 0-Linked Carbohydrates and Construction of Full Length Recombinant cDNA Clones....Pages 201-213
DNA Sequencing Studies of Genomic cDNA Clones of Avian Infectious Bronchitis Virus....Pages 215-224
The Genome of Transmissible Gastroenteritis Virus (TGEV)....Pages 225-226
Biology of Coronaviruses 1983....Pages 227-235
MHV-A59 Pathogenesis in Mice....Pages 237-245
Detection of MHV-A59 RNA by In Situ Hybridization....Pages 247-257
Virological and Immunological Aspects of Coronavirus Induced Subacute Demyelinating Encephalomyelitis in Rats....Pages 259-270
A One Year Study of Coronavirus SD Infection in Mice....Pages 271-276
Immunosuppression with Cyclophosphamide Does Not Prevent Demyelination or Result in Uncontrolled Viral Replication in Coronavirus SD Infected Mice....Pages 277-278
 In Vivo and In Vitro Models of Demyelinating Diseases — VIII: Genetic, Immunologic and Cellular Influences on JHM Virus Infection of Rats....Pages 279-298
Restricted Replication of a Temperature Sensitive Mutant of MHV-A59 in Mouse Brain Astrocytes....Pages 299-300
Replication of Murine Coronaviruses in Somatic Cell Hybrids Formed Between a Mouse Fibroblast Cell Line and Either a Rat Schwannoma Line or a Rat Glioma Line....Pages 301-313
Persistent In Vitro Infection with Mouse Hepatitis Virus 3....Pages 315-326
Characterization of MHV-A59 Persistently Infected Cells....Pages 327-329
Fine Specificity and Genetic Restriction of T Cell Clones Specific for Mouse Hepatitis Virus, Strain JHM....Pages 331-343
The Immune Response to Mouse Hepatitis Virus: Genetic Variation in Antibody Response and Disease....Pages 345-364
Pathogenic Differences Between Various Feline Coronavirus Isolates....Pages 365-380
Expression of Feline Infectious Peritonitis (FIP) Coronavirus Antigens on the Surface of Feline Macrophage-Like Cells....Pages 381-382
Role of Circulating Antibodies and Thymus-Dependent Lymphocytes in Production of Effusive Type Feline Infectious Peritonitis After Oral Infection....Pages 383-384
Interactions of Porcine Enteric Coronavirus TGEV with Macrophages and Lymphocytes....Pages 385-386
Effect of Stomach and Gut Juices on Infectivity of Low and High Passaged Strains of T.G.E. Coronavirus: Properties of a Virus Mutant Resistant to Inactivation by Stomach Juice Obtained by Cycles of Survivor Selection in Tissue Culture....Pages 387-388
Pathogenicity of Mouse Hepatitis Virus, MHV-2cc, From a Persistently Infected DBT Cell Line....Pages 389-390
The Pathogenesis and Age Related Susceptibility of OC43 Virus in Mice....Pages 391-392
Failure to Detect Coronavirus SK Antigen in Multiple Sclerosis Brain Tissue by Autoradiography....Pages 393-394
Antiviral Action of Interferon in the Bovine Species: Study In Vitro and In Vivo ....Pages 395-396
The Effects of Mouse Hepatitis Virus Type 3 on the Microcirculation of the Liver in Inbred Strains of Mice....Pages 397-399
Back Matter....Pages 401-409