Molecular and Quantum Pharmacology: Proceedings of the Seventh Jerusalem Symposium on Quantum Chemistry and Biochemistry Held in Jerusalem, March 31st–April 4th, 1974

Front Matter....Pages I-IX
Introductory Remarks On Pharmacological Receptors....Pages 1-7
The Adventures of a Quantum-Chemist in the Kingdom of Pharmacophores....Pages 9-36
Quantitative Structure-Activity Relationships....Pages 37-41
Imidazole Tautomerism of Histamine Derivatives....Pages 43-53
The Conformation of Histamine, 5-Hydroxytryptamine and Some Related Derivatives in Aqueous Solution....Pages 55-66
Molecular Orbital Calculations On Catecholamines; Theory and Experiment....Pages 67-76
The Conformation of Catecholamines in Solution....Pages 77-93
Molecular Factors and Activity in Psychopharmacologically Active Compounds....Pages 95-103
An Approach To Possible Correlations Between Activity And Conformation In Some Classes Of Psychotropic Drugs....Pages 105-118
Studies of the Conformation in Solution of Molecules Related to Acetylcholine....Pages 119-129
Solvent-Dependent Conformational Studies of Acetylcholine and Some Related Molecules....Pages 131-152
Theoretical Studies of Solvent Effects on the Conformational Stability of Cholinergic Molecules....Pages 153-178
Conformational Isomerism in Drug Action: Does the Free Energy of Binding Induce the Pharmacophoric Conformation of Semi-Rigid Muscarinic Agonists?....Pages 179-187
Studies on the Cholinergic Receptor of Squid Optic Ganglia....Pages 189-209
Squid Nerve Type DFPase: A Consideration of Molecular Structures....Pages 209-211
Stereochemical Similarities in Chemically Different Antiepileptic Drugs....Pages 213-228
Molecular Orbital Calculations on Anti-Epileptic Compounds....Pages 229-240
A Conformational Study of Antihistaminic Pheniramines in Solution....Pages 241-259
NMR Studies of Solution Conformations of Physiologically Active Amino-Acids....Pages 261-268
The Molecular Structures of the Phenothiazine Derivatives, Chlorpromazine, Thiethylperazine and Thioridazine, and a Discussion Of The Mechanism Of Action....Pages 269-300
Conformational Studies on Hormonal Peptides Using Nuclear Magnetic Resonance Spectroscopy....Pages 301-312
Conformational Studies of Cyclotetradepsipeptides and Analogues Related To Serratamolide....Pages 313-318
 Ab Initio Calculations on Large Molecules Using Molecular Fragments. Initial Studies on Prostaglandin Pgf 1β ....Pages 319-332
A Molecular Orbital Study of Some Substituted Benzyl Propynyl Ethers as Insecticide Synergists....Pages 333-347
The Role of Conformation and Configuration in the Interaction of 4-Phenylpiperidines with Analgetic Receptors....Pages 349-353
Quantum Chemical Studies of Morphine-Like Opiate Narcotics: Effect of Polar Group Variations....Pages 355-389
Calculations on Unstable Conformations of Histamine and Methylhistamines....Pages 391-400
Model Studies on the Conformational Lability and Carbon-Binding Abilities of Antibiotic Cyclic Depsipeptides....Pages 401-411
Conformational Studies of Thyroid Hormones and Analogues....Pages 413-428
Intermolecular Interactions in Adenine Barbiturate Complexes....Pages 429-439
Theory of Hydrophobic Bonding....Pages 441-455
A Novel Hydrophobic Parameter for use in Structure Activity Relationship (SAR) Studies....Pages 457-463
Sequence Specificity in the Interaction of Actinomycin D with Deoxydinucleotides as a Model for the Binding of the Drug to DNA....Pages 465-471
Structural Properties of Purine and Pyrimidine Analogs....Pages 473-500
 31 P-Nuclear Magnetic Resonance Study of ATP and ATP-G-Actin: Direct Evidence for Pβ and Pγ Involvement in Nucleotide Binding....Pages 501-513
Interest of Quantum Mechanical Calculations for the Design of Anticancerous Drugs in the Series of Ellipticines....Pages 515-535
Non-Specific Inhalation Stimulants as a Special Case in the Theory of Anesthesia....Pages 537-548
Theoretical Studies on the Reaction Mechanism of Cytotoxic Aromatic Nitrogen Mustards....Pages 549-572
The Molecular Structure of the Sodium Channel....Pages 573-581
On Mechanisms and Treatments of Metal Allergies....Pages 583-586
Concluding Remarks....Pages 587-591