Molecular and Cellular Biology of Prostate Cancer

Front Matter....Pages i-xii
Tissue Specificity and Cell Death are Associated with Specific Alterations in Nuclear Matrix Proteins....Pages 1-13
Mechanism of Growth Regulation of Androgen Responsive Cells....Pages 15-26
The Impact of Androgen, Extracellular Matrix, and Stroma Upon Proliferation and Differentiation of Benign and Malignant Prostate Epithelial Cells....Pages 27-50
Therapeutic Approaches to Activating Programmed Cell Death of Androgen-Independent Prostatic Cancer Cells....Pages 51-63
Cell Motility and Structural Harmonics in Prostate Cancer....Pages 65-72
Back Matter....Pages 73-74
Studies of the Endocrine and Paracrine Effect of Tumor Produced Factors in Human Genitourinary Cancers....Pages 75-79
Fibroblast Growth Factor: Implications in the Etiology of Benign Prostatic Hyperplasia....Pages 81-90
Fibroblast-Mediated Human Epithelial Tumor Growth and Hormonal Responsiveness in Vivo....Pages 91-102
Polyamine Requirement of Prostate Cancer Cell Proliferation....Pages 103-114
Heparin-Binding (Fibroblast) Growth Factor/Receptor Gene Expression in the Prostate....Pages 115-126
Characterization and Partial Purification of a Non-Heparin-Binding Prostate Growth Factor from Cancerous Human Prostate....Pages 127-140
Back Matter....Pages 141-145
Transforming Growth Factor α: A Potential Autocrine Growth Regulator in Prostatic Carcinoma....Pages 147-156
Prostatic Growrh Factors (PrGFs)——From the Identification of Probasin to the Role of PrGFs....Pages 157-165
Urogenital Sinus Derived Growth Inhibitory Factor....Pages 167-174
Growth Factor Antagonists in Prostatic Cancer: Suramin and Cytotoxic Polyamines as Potential Therapy....Pages 175-184
Transforming Growth Facfors in Human Prostate Cancer....Pages 185-202
Gene Products as the Motivating Force in the Prostate Cell’s Response to Androgens....Pages 203-213
Back Matter....Pages 215-217
Molecular Biology of Prostate-Specific Antigen....Pages 219-222
Structure and Expression of the Androgen Receptor in Normal Tissues and in Prostate Carcinoma Cell Lines....Pages 223-227
Structural Analysis and Gene Expression of TR2 Receptor and TR3 Receptor....Pages 229-234
Back Matter....Pages 261-266
cDNA Cloning, Antibody Production and Immunohistochemical Localization of the Androgen Receptor....Pages 235-241
New Approaches to Studies on the Androgen Receptor....Pages 243-252
Specific Receptors for Vitamin D 3 in Human Prostatic Carcinoma Cells....Pages 253-260
Back Matter....Pages 261-266
Role of Androgens and Extracellular Matrix in the Growth and Differentiation of Benign and Malignant Prostate Epithelial Cells....Pages 267-269
Tissue Specificity and Cell Death are Associated with Specific Alterations in Nuclear Matrix Proteins....Pages 271-272
Effect of Transformation on Rat Prostatic Fibroblasts: Alterations in Extracellular Matrix and Cytoskeleton Gene Expression with Retention of Androgen Responsiveness and Androgen Receptor Expression....Pages 273-274
A Potential Role for the MDR-1 Gene in the Development of Androgen-Independent Tumors....Pages 275-276
Relevance of Low Androgen Levels and Adrenal Androgens in the Growth of Transplantable Human Prostatic Carcinomas....Pages 277-278
Growth-Stimulating Effect of Growth Factor(s) from Androgen Independent Tumor Cells (CS 2-Cell) on Androgen Responsive Tumor Cells (SC 115-Cell)....Pages 279-279
The Cellular Form of Human Prostatic Acid Phosphatase May Function as a Phosphotyrosyl Protein Phosphatase in Cells....Pages 281-284
Expression of PSA in LNCaP Cells in Culture....Pages 285-286
Allelic Expression of the Mouse Ren-1 Genes in the Anterior Prostate (Coagulating Gland)....Pages 287-287
Back Matter....Pages 363-367
Genomic Alterations in Prostatic Cancer....Pages 289-297
Regulation of Gene Expression in the Prostate....Pages 299-314
Androgen Regulation of HBGF-I (aFGF) mRNA and Characferization of the Androgen-Receptor mRNA in the Human Prostate Carcinoma Cell Line-LNCaP/A-Dep....Pages 315-330
DNA Methylation, Differentiation and Cancer....Pages 331-336
Evidence for the Involvement of Genetic Differences and Mesenchymal Factors in the Progression of Oncogene-Induced Prostate Cancer in Reconstituted Mouse Prostate....Pages 337-344
Differential Hybridization Analysis as a Tool to Study Prostatic Cancer Metastasis....Pages 345-354
Molecular Biology of Androgen Receptors in Prostate Cancer Cells....Pages 355-361
Back Matter....Pages 369-383