Molecular and Cellular Aspects of Muscle Contraction

Front Matter....Pages i-xiv
Front Matter....Pages 1-1
Myosin Light Chain Composition in Non-Failing Donor and End-Stage Failing Human Ventricular Myocardium....Pages 3-15
Study of the Vertebrate MHC Multigene Family During Heart Development....Pages 17-30
Myosin-Binding Protein C (MyBP-C) in Cardiac Muscle and Contractility....Pages 31-41
The Endocardial Endothelial Na + /K + Atpase and Cardiac Contraction....Pages 43-56
KLF5/BTEB2, A Krüppel-like Zinc-finger Type Transcription Factor, Mediates Both Smooth Muscle Cell Activation And Cardiac Hypertrophy....Pages 57-66
Regulation of the RHO Signaling Pathway by Excitatory Agonists in Vascular Smooth Muscle....Pages 67-75
Human Heart Failure: Dilated Versus Familial Hypertrophic Cardiomyopathy....Pages 77-88
Regulation of Smooth Muscle Contraction by Calcium, Monomeric Gtpases of the Rho Subfamily and Their Effector Kinases....Pages 89-99
Front Matter....Pages 101-101
Bio-Nanomuscle Project: Contractile Properties of Single Actin Filaments in an A-Band Motility Assay System....Pages 103-110
Development of an Apparatus to Control Load by Electromagnet for a Motility System In Vitro ....Pages 111-118
High-Resolution Imaging of Myosin Motor in Action by a High-Speed Atomic Force Microscope....Pages 119-127
Translation Step Size Measured in Single Sarcomeres and Single Filament Pairs....Pages 129-141
Motor Function of Unconventional Myosin....Pages 143-157
Switch 1 Opens on Strong Binding to Actin....Pages 159-167
Gene Transfer of Troponin I Isoforms, Mutants, and Chimeras....Pages 169-174
A Hypothesis About Myosin Catalysis....Pages 175-181
In Vitro Actomyosin Motility in Deuterium Oxide....Pages 183-192
Front Matter....Pages 193-193
NMR Structural Study of Troponin C C-Terminal Domain Complexed with Troponin I Fragment from Akazara Scallop....Pages 195-201
Calcium Binding to Troponin C as a Primary Step of the Regulation of Contraction....Pages 203-213
Isolation and Characterization of 190K Protein from Aorta Smooth Muscle....Pages 215-220
Front Matter....Pages 193-193
Several Aspects of Calcium Regulator Mechanisms Linked to Troponin....Pages 221-229
Front Matter....Pages 231-231
X-Ray Interference Evidence Concerning the Range of Crossbridge Movement, and Backbone Contributions to the Meridional Pattern....Pages 233-242
Modeling Analysis of Myosin-Based Meridional X-Ray Reflections from Frog Skeletal Muscles in Relaxed and Contracting States....Pages 243-249
Myosin Filament Structure and Myosin Crossbridge Dynamics in Fish and Insect Muscles....Pages 251-266
Use of Sinusoidal Length Oscillations to Detect Myosin Conformation by Time- Resolved X-Ray Diffraction....Pages 267-277
Orientation and Motion of Myosin Light Chain and Troponin in Reconstituted Muscle Fibers as Detected by ESR with a New Bifunctional Spin Label....Pages 279-284
Molecular Organizations of Myofibrils of Skeletal Muscle Studied by Atomic Force Microscopy....Pages 285-294
Three-Dimensional Structural Analysis of Individual Myosin Heads Under Various Functional States....Pages 295-304
Helical Order in Myosin Filaments and Evidence for One Ligand Inducing Multiple Myosin Conformations....Pages 305-316
Evidence for the Involvement of Myosin Subfragment 2 in Muscle Contraction....Pages 317-332
Front Matter....Pages 333-333
A Study of Lamellipodial Membrane Dynamics by Optical Trapping Technique: Implication of Motor Activity in Movements....Pages 335-345
Actin Dynamics in Neuronal Growth Cone Revealed With a Polarized Light Microscopy....Pages 347-359
Themodynamic Mechano-Chemistry of Single Motor Enzymes....Pages 361-367
Front Matter....Pages 369-369
Cooperative Activation of Skeletal and Cardiac Muscle....Pages 371-379
Measurement of Force Developed by a Single Cardiac Myocyte Using Novel Carbon Fibers....Pages 381-387
The Special Structure and Function of Troponin I in Regulation of Cardiac Contraction and Relaxation....Pages 389-402
Pharmacological Calcium Sensitivity Modulation of Cardiac Myofilaments....Pages 403-410
20-Hydroxyeicosatetraenoic Acid Potentiates Contractile Activation of Canine Basilar Artery in Response to Stretch Via Protein Kinase Cα- Mediated Inhibition of Calcium- Activated Potassium Channel....Pages 411-416
Distinct Contractile Systems for Electromechanical and Pharmacomechanical Coupling in Smooth Muscle....Pages 417-426
Front Matter....Pages 427-427
Force Response to Stretches in Activated Frog Muscle Fibres at Low Tension....Pages 429-439
Front Matter....Pages 427-427
Molecular Step(s) of Force Generation....Pages 441-457
Rates of Force Generation in Drosophila Fast and Slow Muscle Types Have Opposite Responses to Phosphate....Pages 459-468
Does Cross-Bridge Activation Determine the Time Course of Myofibrillar Relaxation?....Pages 469-479
Inter-Sarcomere Dynamics in Muscle Fibres....Pages 481-500
Stretch-Induced Force Enhancement and Stability of Skeletal Muscle Myofibrils....Pages 501-515
Adaptations in Titin’s Spring Elements in Normal and Cardiomyopathic Hearts....Pages 517-531
An X-Ray Diffraction Study on Contraction of Rat Papillary Muscle With Different Afterloads....Pages 533-539
Front Matter....Pages 541-541
Role of the T-System and the Na-K Pump on Fatigue Development in Phasic Skeletal Muscle....Pages 543-555
Mitochondrial Ca 2+ in Mouse Soleus Single Muscle Fibres in Response to Repeated Tetanic Contractions....Pages 557-562
Cellular Mechanisms of Skeletal Muscle Fatigue....Pages 563-571
Myofibrillar Determinants of Rate of Relaxation in Skinned Skeletal Muscle Fibers....Pages 573-582
Force, Sarcomere Shortening Velocity and ATP-ASE Activity....Pages 583-602
Evidence for High Mechanical Efficiency of Cross-Bridge Powerstroke in Skeletal Muscle....Pages 603-612
Rate of Actomyosin ATP Hydrolysis Diminishes During Isometric Contraction....Pages 613-626
Energy Storage During Stretch of Active Single Fibres....Pages 627-634
Three Dimensional Ultrasound Analysis of Fascicle Orientation in Human Tibialis Anterior Muscle Enables Analysis of Macroscopic Torque at the Cellular Level....Pages 635-645
General Discussion Part I....Pages 647-654
Special Talk: The Beginning of Low-Angle X-Ray Diffraction Work on Living Muscles....Pages 655-660
General Discussion Part II....Pages 661-669
General Discussion Part III....Pages 671-681
Front Matter....Pages 541-541
Concluding Remarks : Progress in Determining the Detailed Mechanism of Muscle Contraction....Pages 683-688
Back Matter....Pages 689-701