Modified Nucleosides and Cancer

Front Matter....Pages I-XII
Organization and Expression of tRNA Genes in Drosophila Melanogaster....Pages 1-14
Chemical Nature, Properties, Location, and Physiological and Pathological Variations of Modified Nucleosides in tRNAs....Pages 15-46
Front Matter....Pages 47-47
Formation and Removal of Methylated Nucleosides in Nucleic Acids of Mammalian Cells....Pages 49-62
Structural Modifications and Repair of DNA in Neuro-Oncogenesis by N-Ethyl-N-nitrosourea....Pages 63-76
Role of Extent and Persistence of DNA Modifications in Chemical Carcinogenesis by Aromatic Amines....Pages 77-89
Can DNA Methylation Regulate Gene Expression?....Pages 90-102
tRNA Alterations in Cancer....Pages 103-120
Tumor-Specific tRNA Modifications in Mouse Plasmacytomas and Other Tumors....Pages 121-132
Alterations in Post-Transcriptional Modification of the Y Base in Phenylalanine tRNA from Tumor Cells....Pages 133-145
Why Is Tumor tRNA Hypomodified with Respect to Q Nucleoside?....Pages 146-159
The Effects of Growth Factors on tRNA Lys Modification....Pages 160-170
Perturbation of the Mitochondrial Lysine tRNA Population by Virus-Induced Transformation or Stress of Mammalian Cells: Functional Properties and Nucleotide Sequence of a Mitochondrially Associated Lysine tRNA....Pages 171-183
Involvement of tRNA in Retrovirus Expression: Biological Implications of Reverse Transcriptase-Primer tRNA Interactions....Pages 184-190
Front Matter....Pages 191-191
Enzymatic Methylation of Chicken Erythrocyte DNA Modified by Two Carcinogens, 2-(N-Acetoxyacetylamino) Fluorene and Methylnitrosourea....Pages 193-201
Inhibition of DNA Methylation by 5-Azacytidine....Pages 202-211
Alteration of Enzymatic DNA Methylation by Chemical Carcinogens....Pages 212-225
Ethionine-Induced Alterations of tRNA Metabolism....Pages 226-236
Processing of tRNA Is Accomplished by a High-Molecular-Weight Enzyme Complex....Pages 237-254
Alteration of tRNA Modification in Eukaryotes: Causes and Consequences....Pages 255-263
Effects of Cortisol on tRNA Methylase Activities in Rat Mammary Carcinoma....Pages 264-274
Front Matter....Pages 191-191
An Approach to Inhibition of Viral Replication: Inhibition of mRNA Methylation....Pages 275-282
Specific Effects of 5-Fluoropyrimidines and 5-Azapyrimidines on Modification of the 5 Position of Pyrimidines, in Particular the Synthesis of 5-Methyluracil and 5-Methylcytosine in Nucleic Acids....Pages 283-297
Front Matter....Pages 299-299
New Applications of Urinary Nucleoside Markers....Pages 301-316
Multivariate Analysis of Urinary RNA Catabolites in Malignancies: Cross-Sectional and Longitudinal Studies....Pages 317-330
Evaluation of Carcinoembryonic Antigen, Tissue Polypeptide Antigen, Placental Alkaline Phosphatase, and Modified Nucleosides as Biological Markers in Malignant Lymphomas....Pages 331-343
Quantitative High-performance Liquid Chromatography Analysis of Modified Nucleosides in Physiological Fluids, tRNA, and DNA....Pages 344-359
Modified Nucleosides in Body Fluids of Tumor-Bearing Patients....Pages 360-377
Increasing Urinary Levels of Modified Nucleosides and Bases During Tumor Development in Mice....Pages 378-387
Comparison of Urinary Modified Nucleosides and Bases in Rats with Hepatomas and Nephroblastomas....Pages 388-400
Characterization and Analysis of Oncofetal tRNA and Its Possible Application for Cancer Diagnosis and Therapy....Pages 401-412
Excretion of Polyamines by Children with Leukemia During Chemotherapy....Pages 413-420
Back Matter....Pages 421-434