Modern Trends in Human Leukemia VIII: New Results in Clinical and Biological Research Including Pediatric Oncology

Front Matter....Pages I-LVII
Front Matter....Pages 1-2
Molecular Analysis of Rearrangements in Philadelphia (Ph 1 ) Chromosome-Positive Leukemia....Pages 3-10
Interactions Between Hematopoietic Growth Factors: The Clinical Role of Combination Biotherapy....Pages 11-21
Front Matter....Pages 23-23
Introduction of Donald Pinkel....Pages 25-26
Species-Specific Therapy of Acute Lymphoid Leukemia....Pages 27-36
Current Issues and Future Directions in Marrow Transplantation....Pages 37-45
The Use of Long-term Bone Marrow Cultures (LTBMC) to Detect Hematotoxic Side Effects of Purging Methods....Pages 46-50
Clinicopathological Features and Prognostic Implications of Immunophenotypic Subgroups in Childhood ALL: Experience of the BFM-ALL Study 83....Pages 51-57
Current Approaches to Therapy for Childhood Lymphoblastic Leukemia: St. Jude Studies XI (1984–1988) and XII (1988)....Pages 58-64
Results of Three Polychemotherapy Programs in Non-Hodgkin’s Lymphomas....Pages 65-70
Results of Treatment in Children with B-Cell Lymphoma: Report on the Polish Leukemia/Lymphoma Study Group....Pages 71-74
Correlations of Clinical and Laboratory Data for Prognosis in Childhood Acute Lymphoblastic Leukemia....Pages 75-77
Central Nervous System Involvement in Non-Hodgkin’s Lymphomas....Pages 78-81
Targeted Plasma Drug Concentration: A New Therapeutic Approach to Relapsed Nonlymphoblastic Leukemia in Children....Pages 82-87
Use of All-trans Retinoic Acid in the Treatment of Acute Promyelocyte Leukemia....Pages 88-96
Simultaneous Presentation of B- and T-Cell Malignant Lymphoma....Pages 97-100
Phenotype Switch in Acute Leukemia Patients After Intensive Chemotherapy....Pages 101-103
Expression of Cell Differentiation Antigens as a Prognostic Factor in Acute Leukemia....Pages 104-108
Immunologic Subclassification of Acute Lymphoblastic Leukemia in Childhood and Prognosis (Modified BFM Protocol)....Pages 109-112
Constellations of Genetic Abnormalities Predict Clinical Outcome in Childhood Malignancies....Pages 113-120
Leukemia Cytogenetics in Children: Results of the German Therapy Studies....Pages 121-126
Front Matter....Pages 23-23
Cytostatic Influence of Thioproline on Peripheral Lymphocytes of Healthy Persons and Non-Hodgkin’s Lymphoma Patients....Pages 127-130
Diversity of Molecular Phenotypes in Acute Leukemias....Pages 131-133
Treatment of Chronic Myelogenous Leukemia with Interferons: Hematologic, Cellular, and Genetic Investigations....Pages 134-138
α Interferon in Myelodysplasia....Pages 139-140
Use of Investigational Drugs as Initial Therapy for Childhood Solid Tumors....Pages 141-148
Xenografts of Pediatric Solid Tumors: Predictive Intermediate Models?....Pages 149-155
Front Matter....Pages 157-157
Stromal-Hematopoietic Interrelationships: Maximov’s Ideas and Modern Models....Pages 159-167
Bone Marrow Stromal Cells in Myelodysplastic Syndromes and Acute Nonlymphocytic Leukemia....Pages 168-171
Growth and Development of Haemopoietic Cells: A Deterministic Process?....Pages 172-177
Limited Proliferative Potential of Primitive Hematopoietic Stem Cells: Hematopoiesis by Clonal Succession....Pages 178-182
The Effect of Human and Rat Fetal Bone on Hematopoiesis In Vitro and In Vivo....Pages 183-187
Aberrant Expression of the Multi-CSF Gene in Hematopoietic Precursor and Stem Cell Lines Initiates Leukemogenic Progression....Pages 188-196
Infection of Multipotent IL-3-dependent Stem Cells With a Retroviral Vector Containing the IL-3 Gene Confers Density-dependent Growth Autonomy Without Blocking Differentiation....Pages 197-205
Isolation of Revertants from a Factor-Independent Myeloid Cell Line....Pages 206-207
Comparison of Factors Which Induce Differentiation of the Murine Myeloid Leukaemic Cell Line M1....Pages 208-213
Establishment of a Leukemic Cell Line MT-ALL With Multilineage Differentiation Potential....Pages 214-219
Establishment of a Hybrid Cell System Between Malignant Burkitt’s Lymphoma Cells and Nonmalignant Lymphoblastoid Cells....Pages 220-222
Effect of Natural and Synthetic Peptides on the Biological Function of Leukemic Cells....Pages 223-225
Mechanisms of Glucocorticoid-Induced Growth Inhibition and Cell Lysis in Mouse Lymphoma Cells....Pages 226-232
Characteristics of 27 Human T-Cell Leukemia Cell Lines With/Without T-Cell Receptors of T3-Tiαβ or T3-Tiγδ Complex....Pages 233-236
Front Matter....Pages 157-157
Intervention in Potential Leukemic Cell Migration Pathway Affects Leukemogenesis....Pages 237-242
Preleukemia in Experimental Leukemogenesis....Pages 243-249
RAS Mutations in Preleukaemias....Pages 250-254
Front Matter....Pages 255-255
Logical Structure of the Immunoregulatory Compartment....Pages 257-259
Analysis of T Suppressor Cell-Mediated Tumor Escape Mechanisms Is Facilitated by the Selective In Vitro Activation of Tumor-specific Ts Cells....Pages 260-262
Role of the Colony-Stimulating Factor-1 Receptor (c- fms ) and Its Ligand in Oncogenesis....Pages 263-267
Activation of CD4-Positive T Cells by Polysaccharide Fractions Isolated from the Cupressaceae Thuja occidentalis L. (Arborvitae).....Pages 268-272
Induction of Nonspecific Cell-Mediated Cytotoxicity: A Multisignal Event and its Cellular Regulation....Pages 273-280
Signal Transduction Mechanisms in Human Natural Killer Cells Mediating Antitumor Immunity....Pages 281-283
Tumor-Specific Antigens and Tumor-Specific Mutant Proteins in Mouse and Man....Pages 284-288
Modification of HLA Expression as a Possible Factor in the Pathogenesis of Burkitt’s Lymphoma....Pages 289-292
Disorders of the Expression of the Multichain IL-2 Receptor in HTLV-I-Associated Adult T-Cell Leukemia....Pages 293-298
Monocyte Interleukin-1 Secretion Is Regulated by the Sequential Action of γ-Interferon and Interleukin-2 Involving Monocyte Surface Expression of Interleukin-2 Receptors....Pages 299-315
The Expression of T-Cell Receptor-Associated Proteins in Normal and Leukaemic Immature T Cells....Pages 316-328
Front Matter....Pages 329-329
Molecular Analysis of the Translocation Breakpoint in a Philadelphia-positive, bcr-negative ALL Patient....Pages 331-334
Cloning of the Breakpoint Junction of the Translocation 14;19 in Chronic Lymphocytic Leukemia....Pages 335-336
Variant Breakpoint Positions on Chromosome 22 in Ph′-Positive Chronic Myelogenous Leukemias....Pages 337-338
Expression of Cellular Oncogenes in Primary Cells from Human Leukemias....Pages 339-342
 c-myc and c-myb Oncoproteins During Induced Maturation of Human Myeloid and Erythroid Leukaemic Lines....Pages 343-346
Isolation and Characterisation of a Myeloid Leukaemia Inducing Strain of Feline Leukaemia Virus....Pages 347-351
Front Matter....Pages 329-329
Cell Lineage Specificity of Chromatin Configuration and Gene Expression in Haemopoietic Progenitor Cells....Pages 352-356
Chromosomal Translocations Involving the T-Cell Receptor δ Chain Locus and Two Loci on the Short Arm of Chromosome 11....Pages 357-359
Genetic Markers for Oncogenes, Growth Factors, and Cystic Fibrosis....Pages 360-365
Search for Genes Critical for the Early and/or Late Events in Carcinogenesis: Studies in Xiphophorus (Pisces, Teleostei)....Pages 366-385
 ras Gene Mutations and Clonal Analysis Using RFLPs of X-chromosome Genes in Myelodysplastic Syndromes....Pages 386-389
Close Localization of the Genes for GM-CSF and IL3 in Human Genome....Pages 390-392
HIV-1, HTLV-I and the Interleukin-2 Receptor: Insights into Transcriptional Control....Pages 393-401
HIV-I Replication Requires an Intact Integrase Reading Frame....Pages 402-405
Use of a HIV-1 Retroviral Vector System for Gene Transfer into Human Cells....Pages 406-406
Multistage Mastocytoma Model Characterized by Autocrine IL-3 Production....Pages 407-410
Purified Bovine NF-κB Recognizes Regulatory Sequences in Multiple Genes Expressed During Activation of T- and B-Lymphocytes....Pages 411-415
Hematopoietic Growth Control by the T-Cell CD2 Determinant is Exerted at a Pretranslational Level....Pages 416-422
Oncogene Cooperation and B-Lymphoid Tumorigenesis in E µ - myc Transgenic Mice....Pages 423-427
Even Transcriptionally Competent Proviruses Are Silent in Bovine Leukemia Virus Induced Tumor Cells....Pages 428-432
Restriction Fragment Length Polymorphism of the c-Ha- ras -1 Proto-Oncogene as a Marker of Genome Alterations and Susceptibility to the Development of Some Human Carcinomas....Pages 433-435
Analysis of c- raf Oncogene Expression in Gastrointestinal Tumor Cells....Pages 436-440
c- ets -2 and the Mitogenic Signal Pathway....Pages 441-448
Induction of Lymphokine-Activated Killer (LAK) Cells Against Human Leukemia Cells....Pages 449-452
Expression and Chromosomal Assignment of a Novel Protein-Tyrosine Kinase Gene Related to the Insulin Receptor Family....Pages 453-460
Genetic Characterization of a Human Endogenous Retroviral Element Located on Chromosome 18q21....Pages 461-463
Front Matter....Pages 329-329
Human Endogenous Retrovirus-like Sequences....Pages 464-477
Front Matter....Pages 479-479
Fantasy of a “Virus” from the Inorganic World: Pathogenesis of Cerebral Amyloidoses by Polymer Nucleating Agents and/or “Viruses”....Pages 481-499
Clay Minerals — Blueprints of Early Life....Pages 500-511
Modern Coding Sequences Are in the Periodic-to-Chaotic Transition....Pages 512-519
Translation to Human Temperaments of the Tyrosin-Kinase Active Site of the Human Insulin Receptor β-Chain....Pages 520-526
Back Matter....Pages 527-532