Modern Trends in Human Leukemia VII: New Results in Clinical and Biological Research Including Pediatric Oncology

Front Matter....Pages I-XLVII
Front Matter....Pages 1-2
Introduction for Harald zur Hausen....Pages 3-4
Viruses in Human Tumors....Pages 5-13
Introduction for Donald Metcalf....Pages 14-15
Hemopoietic Growth Factors and Oncogenes in Myeloid Leukemia Development....Pages 16-25
Front Matter....Pages 27-27
Poster Award for U. Creutzig....Pages 29-29
Treatment Results in Childhood AML, with Special Reference to the German Studies BFM-78 and BFM-83....Pages 30-34
The Treatment of Acute Myelogenous Leukemia....Pages 35-36
Long-Term Follow-up After Therapy Cessation in Childhood Acute Lymphoblastic Leukemia....Pages 37-38
Progress in Treatment of Advanced Non-Hodgkin’s Lymphoma in Children — Report on Behalf of the Polish Children’s Leukemia/Lymphoma Study Group....Pages 39-42
Strategies for the Future Chemotherapy of Human Immunodeficiency Virus (HIV)....Pages 43-51
Intra-arterial Cis -platinum in Osteosarcoma....Pages 52-56
In Vitro Treatment of Bone Marrow from Patients with T-Cell Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphoma Using the Immunotoxin WT1-Ricin A....Pages 57-58
Ablative Therapy Supported by Autologous Bone Marrow Transplantation with In Vitro Treatment of Marrow in Patients with B-Cell Malignancy....Pages 59-61
Use of Autologous Bone Marrow Transplantation in Acute Myeloid Leukemia....Pages 62-66
Monoclonal-Antibody-Purged Autologous Bone Marrow Transplantation for Relapsed Non-T-Cell Acute Lymphoblastic Leukemia in Childhood....Pages 67-74
The Use of Cultured Bone Marrow Cells for Autologous Transplantation in Patients with Acute Myeloblastic Leukemia....Pages 75-78
Bone Marrow Transplantation in Leukemia in the Absence of an HLA-Identical Sibling Donor....Pages 79-85
Bone-Marrow Purging with Monoclonal Antibodies and Human Complement in ALL and AML....Pages 86-88
Purging of Bone Marrow with a Cocktail of Monoclonal Antibodies (VIB-pool) for Autologous Transplantation....Pages 89-91
Autologous Bone Marrow Transplantation in Paediatric Solid Tumours....Pages 92-96
Front Matter....Pages 27-27
Cytokines with Possible Clinical Utility....Pages 97-102
Biological Approaches to Cancer Therapy....Pages 103-109
IL-2 Receptors in Adult T-Cell Leukemia: A Target for Immunotherapy....Pages 110-115
Application of Interleukin 2 in Neuroblastoma....Pages 116-119
Biologic Agents for the Management of Hematological Disorders: Chronic Myeloid Leukemia....Pages 120-122
Human B-Cell Growth and Differentiation Factors, and Their Effects on Leukemic B-Cells....Pages 123-125
Production of Three Monoclonal Antibodies — A01, B05, and Cll — Against B-Cell Leukemia....Pages 126-131
Natural Killer Activity in Preleukemic States....Pages 132-135
Some Karyotypic Aspects of Human Leukemia....Pages 136-140
Nonisotopic In Situ Hybridization for Mapping Oncogenic Sequences....Pages 141-144
Persistence of CML Despite Deletion of Rearranged bcr/c-abl Sequences....Pages 145-148
Similar Molecular Alterations Occur in Related Leukemias With and Without the Philadelphia Chromosome....Pages 149-152
Rearrangement of the bcr Gene in Philadelphia-Chromosome-Negative Chronic Myeloid Leukemia....Pages 153-159
Rearrangement of bcr and c-abl Sequences in Ph-positive Acute Leukemias and Ph-negative CML — an Update....Pages 160-162
Molecular Cloning and Serological Characterization of an Altered c-abl Gene Product Produced in Ph 1 CML Patients....Pages 163-166
Human Follicular Lymphomas: Identification of a Second t(14;18) Breakpoint Cluster Region....Pages 167-171
Amino Acid Substitution at Position 13 of the N -ras Gene in a Non-Hodgkin’s Lymphoma Patient....Pages 172-174
Loss of Hematopoietic Progenitor Cells CFU-GEMM, BFU-E, CFU-Mk, and CFU-GM in the Acquired Immunodeficiency Syndrome (AIDS)?....Pages 175-176
Sensitivity of Stromal Elements from Human Bone Marrow Cells to Cytosine Arabinoside In Vitro....Pages 177-180
The Secretion of Plasminogen Activators by Human Bone Marrow Progenitor Cells....Pages 181-184
Front Matter....Pages 27-27
Leukemic Colony-Forming Cells in Acute Myeloblastic Leukemia: Maturation Hierarchy and Growth Conditions....Pages 185-190
Hexosaminidase I Indicates Maturation Disarrangement in Acute Leukemias....Pages 191-194
Membrane-Microfilament Interactions in the Cells of B-Chronic Lymphocytic Leukemia....Pages 195-196
Front Matter....Pages 197-197
 ts -Oncogene-Transformed Erythroleukemic Cells: A Novel Test System for Purifying and Characterizing Avian Erythroid Growth Factors....Pages 199-209
Biological Activities of Recombinant Human Granulocyte Colony Stimulating Factor (rhG-CSF) and Tumor Necrosis Factor: In Vivo and In Vitro Analysis....Pages 210-220
Molecular Properties and Biological Activity of Human Macrophage Growth Factor, CSF-1....Pages 221-227
Regulatory Control of the Epidermal Growth Factor Receptor Tyrosine Kinase....Pages 228-232
Cellular Specificity and Molecular Characteristics of the Binding of Colony-Stimulating Factors to Normal and Leukemic Cells....Pages 233-239
Fractionation of CSF Activities from Human Placental Conditioned Medium....Pages 240-243
Proliferative Effects of a Recombinant Human Granulocyte Colony-Stimulating Factor (rG-CSF) on Highly Enriched Hematopoietic Progenitor Cells....Pages 244-247
The myc Oncogene and Lymphoid Neoplasia: From Translocations to Transgenic Mice....Pages 248-251
Cloning of Human Thymic Subcapsular Cortex Epithelial Cells by SV40 ori − Transfection....Pages 252-256
v-H- ras Gene Reduces IL-3 Requirement in PB-3c Mastocytes In Vitro Followed by Autokrine Tumor Formation In Vivo....Pages 257-260
Modification of Oncogenicity of Tumour Cells by DNA-Mediated Gene Transfer....Pages 261-262
A Human Leukemic T-Cell Line Bears an Abnormal and Overexpressed c- myc Gene: Molecular and Functional Characterization of the Rearrangement....Pages 263-265
Association of the Heme-Controlled eIF-2α Kinase with Spectrin-Derived Peptides....Pages 265-267
Involvement of the Membrane Skeleton in the Regulation of the cAMP-Independent Protein Kinase and a Protein Phosphatase that Control Protein Synthesis....Pages 268-273
Lineage Determination During Haemopoiesis....Pages 274-277
Clinical Implications of Tumor Heterogeneity....Pages 278-282
Tumour Cell Heterogeneity and the Biology of Metastasis....Pages 283-285
Front Matter....Pages 197-197
Cancer Clonality and Field Theory....Pages 286-288
Leukemia Progression: Role of Tissue Disorganization....Pages 289-298
The Nucleoskeleton: Active Site of Transcription and Replication....Pages 299-303
Front Matter....Pages 305-305
Henry Kaplan Award for H. J. Stauss....Pages 307-307
Identification of a Gene Encoding a Tumor-Specific Antigen that Causes Tumor Rejection....Pages 308-313
Formation of a Hybrid bcl -2/Immunoglobulin Transcript as a Result of t(14;18) Chromosomal Translocation....Pages 314-319
Involvement of the D Segment ( DQ 52 ) Nearest to the J H Region in Immunoglobulin Gene Rearrangements of Lymphoid-Cell Precursors....Pages 320-323
Pattern Recognition Among T-Cell Epitopes....Pages 324-331
Regulation of Ig Gene Expression in Murine B-Lymphocytes....Pages 332-336
Isolation, Biochemical Analysis, and N -Terminal Amino Acid Sequence of a Cell Surface Glycoprotein that Binds to the “Erythrocyte Receptor” of T-Lymphocytes....Pages 337-340
The Regulation of T-Cell Proliferation: A Role for Protein Kinase C....Pages 341-346
Activation of Natural Killer Function Through the T11/E Rosette Receptor....Pages 347-350
Tumor Necrosis Factor:A Potent Mediator of Macrophage-Dependent Tumor-Cell Killing....Pages 351-354
Organ-Associated Macrophage Precursor Cells as Effector Cells Against Tumor Targets and Microorganisms....Pages 355-359
Immune Functions and Hematopoietic Progenitor Cell Activity in Plasmacytoma-Bearing Mice Cured by Melphalan....Pages 360-361
Recombinant Vaccinia Viruses as Live Vaccines....Pages 362-366
Use of Fluorescence-Activated Cell Sorting to Select Hybrid Hybridomas Producing Bispecific Monoclonal Antibodies....Pages 367-368
Front Matter....Pages 369-369
Henry Kaplan Award for J. C. Neil....Pages 371-371
Viral Transduction of Host Genes in Naturally Occurring Feline T-Cell Leukaemias: Transduction of myc and a T-Cell Antigen Receptor β-Chain Gene....Pages 372-376
Analysis of the Biological Role of Human Papilloma Virus (HPV)-Encoded Transcripts in Cervical Carcinoma Cells by Antisense RNA....Pages 377-379
Front Matter....Pages 369-369
Transcription of Human Papillomavirus Type-18 DNA in Human Cervical Carcinoma Cell Lines....Pages 380-381
Are Haematophagous Insects Vectors for HTLV-I?....Pages 382-386
Neutralization and Receptor Recognition of Human T-Lymphotropic Retroviruses....Pages 387-391
Markers of HTLV-I-Related Virus in Hamadryas Baboon Lymphoma....Pages 392-394
Replication and Pathogenesis of the Human T-Cell Leukemia/Lymphotropic Retroviruses....Pages 395-403
Complete Nucleotide Sequences of Functional Clones of the Virus Associated with the Acquired Immunodeficiency Syndrome, HTLV-III/LAV....Pages 404-406
LAV/HTLV-III: Fine-structure Analysis, Localization of Structural Proteins, and Detection of Envelope Antigens by Patient Sera....Pages 407-409
Transfusion-Acquired HIV Infection Among Immunocompromised Hosts....Pages 410-413
Restricted Neutralization of Divergent HTLV-III/LAV Isolates by Antibodies to the Major Envelope Glycoprotein....Pages 414-422
Interaction of Viral and Cellular Factors with the HTLV-III LTR Target Sequences In Vitro....Pages 423-429
Improvement of HIV Serodiagnosis....Pages 430-433
Incidence of LAV/HTLV-III-Positive Blood Donors....Pages 434-435
Growth of the HTLV-III Strain of Human Immunodeficiency Virus in Different Cell Types....Pages 436-439
Nonhuman Primate Models of Human Hematological Malignancies....Pages 440-444
Modelling of Malignant Lymphoma in Rabbits, Using Oncogenic Viruses of Non-Human Primates....Pages 445-447
Retrovirus-Induced Malignant Histiocytosis in Mice: A Model for the Human Disease....Pages 448-449
Oncogenes: Clinical Relevance....Pages 450-459
Retroviruses with Two Oncogenes....Pages 460-463
Activation of the met Proto-oncogene in a Human Cell Line....Pages 464-468
Molecular-Genetic Analysis of myc and c -Ha- ras Proto-oncogene Alterations in Human Carcinoma....Pages 469-473
Front Matter....Pages 369-369
Interaction of Promoters and Oncogenes During Transfection....Pages 474-476
Conversion of ras Genes to Cancer Genes....Pages 477-481
Identification of the Bovine Leukemia Virus Transactivating Protein (p34 x )....Pages 482-487
Monoclonal Antibodies Against the Viral and Human Cellular myb Gene Product....Pages 488-492
Atavistic Mutations Reflect the Long Life Span of Dispensable Genes....Pages 493-495
Cancer Genes Generated by Rare Chromosomal Rearrangements Rather than Activation of Oncogenes....Pages 496-510
Repetition as the Essence of Life on this Earth: Music and Genes....Pages 511-519
Back Matter....Pages 521-524