Modern Trends in Human Leukemia VI New Results in Clinical and Biological Research Including Pediatric Oncology: Organized on behalf of the Deutsche Gesellschaft für Hämatologie und Onkologie. Wilsede, June 17–20, 1984 Wilsede Joint Meeting on Pediatric Oncology III Hamburg, June 21/22, 1984

Front Matter....Pages I-XXXII
Front Matter....Pages XXIX-XXX
Introduction for N. A. Mitchison....Pages 1-2
Repertoire Purging by Medium Concentration Self-Macromolecules is the Major Factor Determining Helper and Suppressor Repertoire Differences....Pages 3-6
Introduction for P.H. Duesberg....Pages 7-8
Are Activated Proto- onc Genes Cancer Genes?....Pages 9-27
Front Matter....Pages 29-29
Allogeneic Marrow Transplantation from HLA-Identical Siblings in the Acute Leukemias: Baltimore Experience....Pages 31-33
Monoclonal Antibodies and Immunotoxins in Bone Marrow Transplantation: Purging Marrow of ALL or GVHD Cells with Preservation of Stem Cells....Pages 34-38
Bone Marrow Transplantation for Acute Leukemia....Pages 39-41
T Cell Depletion of Donor Marrow for Prevention of Acute Graft-Versus-Host Disease....Pages 42-43
Long-Term Survivors of Adult Acute Nonlymphocytic Leukemia: Fact or Fiction?....Pages 44-47
Risk Groups in a Multicenter Pilot Study for Treatment of Acute Lymphoblastic and Acute Undifferentiated Leukemia in Adults....Pages 48-50
New Approaches to the Treatment of Chronic Myelogenous Leukemia....Pages 51-52
The Feasibility of Opal/High Dose Ara-C Treatment of Adult Acute Lymphoblastic Leukaemia....Pages 53-55
Treatment of Leukemia with Low Dose Ara-C: A Study of 159 Cases....Pages 56-59
Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndrome by Low Dose Cytosine Arabinoside....Pages 60-62
The Results of High Risk Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphoma Total Therapy....Pages 63-66
Adult Acute Lymphoblastic Leukaemia at University Hospital, Malaysia....Pages 67-69
The Epipodophyllotoxin VP16-213 in Combination Chemotherapy for Adults with Acute Nonlymphoblastic Leukaemia....Pages 70-74
Treatment of Acute Lymphoblastic Leukemia in Childhood: A Report for the ALL 77-02 Group....Pages 75-77
Recent Results from Total Therapy Study X for Standard and High Risk Acute Lymphoblastic Leukemia in Children: Recognition of New Clinical and Biologie Risk Features....Pages 78-81
Improved Treatment Results in Childhood Acute Myelogenous Leukemia: An Update of the German Cooperative Study AML-BFM-78....Pages 82-83
Front Matter....Pages 29-29
Clinical Experiences with a Modified BFM Protocol in Childhood Acute Lymphoblastic Leukemia....Pages 84-89
Mechanisms of Drug Resistance in Human Leukemia....Pages 90-95
Summary Overview of Clinical Session....Pages 96-101
Red Cell Transfusions for Polytransfused Patients....Pages 102-106
Gram-Negative Bacteraemia: New Therapeutic Possibilities with Anti-Endotoxin Antibodies....Pages 107-111
Empiric Antimicrobial Therapy in Cancer Patients....Pages 112-118
Prophylaxis of Infection in Granulocytopenic Patients....Pages 119-122
Are Granulocyte Transfusions Helpful in Treating and Preventing Infections?....Pages 123-131
Single Donor Platelet Transfusion....Pages 132-136
Advances in Parenteral Nutrition Support of Children with Neoplastic Diseases....Pages 137-142
Antiemetics in Cancer Chemotherapy....Pages 143-144
Chromosome Abnormalities in Malignant Lymphoma: Biologic and Clinical Correlations....Pages 145-149
Oncogenetic Aspects of Chronic Myelocytic Leukemia....Pages 150-153
Association Between the Philadelphia Chromosome and a Unique abl Transcript....Pages 154-158
Somatic N- ras Oncogene Activation in a Patient with Acute Myeloblastic Leukemia....Pages 159-162
Behavior of Human Leukemic Progenitor Populations in Long-Term Marrow Culture....Pages 163-167
Stromal Progenitor Cells in Bone Marrow of Patients with Aplastic Anemia....Pages 168-171
Dyserythropoiesis in Acute Lymphoblastic Leukemia of Childhood....Pages 172-173
Ultrastructural Analysis of Normal and Leukaemic Cells by the Immunogold Method and Monoclonal Antibodies....Pages 174-179
Immunocytochemical Labelling of Haematological Samples Using Monoclonal Antibodies....Pages 180-182
Front Matter....Pages 29-29
Myelolactoferrin Index (MLF) and Myelopoiesis During Bacterial Infections and Malignant Diseases....Pages 183-186
ß-Hexosaminidase Isoenzyme I: An Early Marker of Hematopoietic Malignancy....Pages 187-189
Analysis of Leukemic Cells with Monoclonal Antibodies in Acute Myelomonocytic Leukemia Suggests Abnormality at an Early Differentiation Stage in Certain Cases....Pages 190-193
Nonspecific Cross-Reacting Antigen as a Marker of Myelocytic Leukemias in Individual Stages of Myelocytic Cell Differentiation....Pages 194-196
Plasminogen Activator as a Prognostic Factor in Hematological Malignancies....Pages 197-199
Immune Status of Leukemia Patients....Pages 200-203
Differential Expression of a Glycoprotein (p15E-RT) of Retroviral Origin in Patients Suffering from Various Hematological Disorders....Pages 204-206
Discrimination of Leukemias, Lymphomas, and Non-Neoplastic Controls by Retroviral Serum Markers....Pages 207-214
Front Matter....Pages 215-215
Modulation of Gene Expression Through DNA-Binding Proteins: Is There a Regulatory Code?....Pages 217-223
Cellular Oncogenes as the Ancestors of Endocrine and Paracrine Growth Factors and Their Evolutionary Relic Status in Vertebrates....Pages 224-227
The Genes That Carcinogens Act Upon....Pages 228-252
Chromosome Alterations in Oncogenesis....Pages 253-260
Chromatin Structure of the Human c- myc Oncogene: Definition of Regulatory Regions and Changes in Burkitt’s Lymphomas....Pages 261-265
Identification of the Human Cellular myc Gene Product by Antibody Against the Bacterially Expressed Protein....Pages 266-268
Oncogenes of Avian Acute Leukemia Viruses are Subsets of Normal Cellular Genes....Pages 269-272
Structure and Function of ras and Blym Oncogenes....Pages 273-276
TLym 1, a Stage-Specific Transforming Gene Which Shares Homology to MHCI Genes and Encodes a Secreted Protein....Pages 277-279
The mil/raf and myc Oncogenes: Molecular Cloning and In Vitro Mutagenesis....Pages 280-283
Characterization of the Number of Carbohydrate Chains on the Avian Erythroblastosis Virus erb B Gene Product and Their Role in Transformation....Pages 284-289
Characterization of Hematopoietic Cells Transformed In Vitro by AEV-H, a v-erb B -Containing Avian Erythroblastosis Virus....Pages 290-297
Front Matter....Pages 215-215
Different Cellular Substrates of Abelson Leukemia Virus Transforming Protein Kinase in Murine Fibroblasts and Lymphocytes....Pages 298-301
Regulin, a Cytoskeleton-Associated Protein Affecting Phosphorylation-Dephosphorylation....Pages 302-305
Viruses as Tumor Initiators and Tumor Promoters....Pages 306-307
Endemic and Sporadic Cases of Epstein-Barr Virus-Positive Burkitt’s Lymphoma: Immunological Characterization of Derived Cell Lines....Pages 308-311
Herpesvirus HVMA: A New Representative in the Group of the EBV-like B-Lymphotropic Herpesviruses of Primates....Pages 312-313
Tumors Induced in Hairless Mice by DNA from Human Malignant Cells....Pages 314-316
The Human T-Cell Leukemia Virus Family, Adult T Cell Leukemia, and AIDS....Pages 317-325
Molecular Studies of Human T Cell Leukemia/Lymphotropic Retroviruses....Pages 326-330
The Molecular Biology of Human T Cell Leukemia Virus and its Roles in Leukemogenesis of Adult T Cell Leukemia....Pages 331-334
HTLV-I Antibodies Associated with Cutaneous T Cell Lymphoma in Denmark....Pages 335-337
Presence of Antibodies to the Human T-Cell Leukemia Virus HTLV I in German Patients with Symptoms of AIDS....Pages 338-341
Roles of HTLV-I p19 and Natural Antibody to HTLV-I in Host Immune Responses....Pages 342-344
Antibodies to Human T-Cell Leukemia Virus-Membrane Antigens in Macaques with Malignant Lymphoma....Pages 345-349
Front Matter....Pages 351-351
Normal Regulators of Growth and Differentiation and the Reversal of Malignancy in Leukemia....Pages 353-362
Self-Renewal of Haemopoietic Stem Cells: The Roles of the Environment, of Growth Factors and of the src Oncogene....Pages 363-371
Coordinated Expression of c- myc Gene and a Multigenic Set May Modulate the Malignant Phenotype in Human Haemopoietic Cell Lines....Pages 372-375
Proliferation In Vivo and In Vitro of Haemopoietic Progenitor Cells Induced by AF-1, a New ras -Containing Retrovirus....Pages 376-379
Cloning and Expression of the Gene for Murine Granulocyte-Macrophage Colony-Stimulating Factor....Pages 380-384
Partial Characterization of Murine Haematopoietic Cell Growth Factor mRNA....Pages 385-387
Molecular Cloning of cDNA for the Human Interleukin-2 Receptor....Pages 388-395
Front Matter....Pages 351-351
Purification of Normal Human T-Cell Growth Factor to Molecular Homogeneity....Pages 396-397
Purification to Apparent Homogeneity and Biochemical Characterization of Human Pluripotent Hematopoietic Colony-Stimulating Factor....Pages 398-401
Differentiation in Myelodysplastic, Myeloid Leukaemic and Normal Haemopoietic Cells: A New Approach Exploiting the Synergistic Interaction Between Differentiation Inducers and DNA Synthesis Inhibitors....Pages 402-408
Vitamin D: Myeloid Differentiation and Proliferation....Pages 409-417
Biological Activities of a Human Pluripotent Hemopoietic Colony-Stimulating Factor....Pages 418-422
A T Lymphocyte-Derived Differentiation-Inducing Factor for Myeloid Leukemia Cells: Purification and Characterization....Pages 423-425
A Model Scheme of Hematopoietic Cell Differentiation Based on Multiple Marker Analysis of Leukemia-Lymphomas: T Cell Lineage....Pages 426-429
Changes in Isoenzyme Patterns Expressed by the Erythroleukemia Cell Lines K-562 and HEL After Induction of Differentiation....Pages 430-432
B Cell Lineage: Part of the Differentiation Program of Human Pluripotent Stem Cells....Pages 433-435
Differentiation Capacity of Null-AL(L) Cells in Culture....Pages 436-440
Evidence of Sternberg-Reed Cells Being Derived from Activated Lymphocytes....Pages 441-444
Production and Characterization of Monoclonal Antibodies Against the Leukemic Cell Line K562....Pages 445-446
Front Matter....Pages 447-447
Lymphocyte and Lymphoma Receptors Utilized in Differentiation, in Homing, and in Lymphomagenesis....Pages 449-454
Quantitative Expression and Function of Differentiation Antigens on Normal and Malignant Lymphoid Cells....Pages 455-460
Development of B Cell Subpopulations in Humans and its Relevance to Malignancy....Pages 461-470
Genetic Determination of the Cytolytic T Lymphocyte Receptor Repertoire....Pages 471-476
Internal Activity of the Immune System and its Physiologie Significance....Pages 477-480
Antigen Presentation by Liposomes....Pages 481-485
Thymic Dendritic Cells Present Blood-Borne Antigens to Medullary Thymocytes In Vivo: A Possible Role in the Generation of the T-Cell Repertoire....Pages 486-491
Natural Defense and Chemical Carcinogenesis....Pages 492-498
Front Matter....Pages 447-447
Genes and Antigens Controlling Tumor Metastases....Pages 499-507
Killer Cells in Leukemia....Pages 508-510
Influence of Colchicine and Cytochalasin B on Pinocytosis, Phagocytosis, and Antibody-Dependent Cell-Mediated Cytotoxicity....Pages 511-513
In Vivo Studies with Covalent Conjugates of Cobra Venom Factor and Monoclonal Antibodies to Human Tumors....Pages 514-517
Back Matter....Pages 519-521