Modern Trends in Human Leukemia V: New Results in Clinical and Biological Research Including Pediatric Oncology

Front Matter....Pages I-XXIX
Front Matter....Pages 1-2
Immunobiology of Lymphoid Malignancy....Pages 3-10
Bone Marrow Transplantation in Leukemia....Pages 11-15
Front Matter....Pages 17-17
Nucleotide Metabolism and Enzyme Inhibitors in Thymic Acute Lymphoblastic Leukaemia....Pages 19-23
Selective Killing of Leukemia Cells by Inhibition of TdT....Pages 24-27
Poly(A)-polymerase Levels in Leukemia....Pages 28-29
Short-term Therapy for Acute Myelogenous Leukaemia in Younger Patients....Pages 30-35
Multicentre Pilot Study for Therapy of Acute Lymphoblastic and Acute Undifferentiated Leukemia in Adults....Pages 36-40
The Treatment of Acute Myelogenous Leukemia in Children and Adults: VAPA Update....Pages 41-45
Improved Results in Treatment of Acute Myelogenous Leukemia in Children — Report of the German Cooperative AML Study BFM-78....Pages 46-50
Acute Myeloid Leukaemia in Childhood: Treatment in the United Kingdom....Pages 51-55
Interferon in Acute Myelogenous Leukaemia: A Preliminary Report....Pages 56-58
Human Interferon-Beta in the Treatment of Non-Hodgkin Lymphoma....Pages 59-61
Results of LSA 2 -L 2 Therapy in Children with High-Risk Acute Lymphoblastic Leukemia and Non-Hodgkin’s Lymphoma....Pages 62-66
Clinical and Epidemiological Observations on Acute Lymphoblastic Leukemia Subtypes at the Sheba Medical Center, Israel....Pages 67-69
The Clinical Pharmacology of Cytosine Arabinoside....Pages 70-75
Enhancement of the Cell-Mediated Lysis of Fresh Human Leukemia Cells by Cytostatic Drugs....Pages 76-77
Secretion of Plasminogen Activators by Human Myeloid Leukemic Cells: Modulation and Therapeutic Correlations....Pages 78-80
Bone Marrow Transplantation in West Germany in Patients with Leukemia....Pages 81-86
Cyclosporin A Following Matched and Mismatched Family Allogeneic Bone Marrow Transplants....Pages 87-89
Autologous Bone Marrow Transplantation in Acute Leukemia and Non-Hodgkin’s Lymphoma: A Phase I Study of 4-Hydroperoxycyclophosphamide (4HC) Incubation of Marrow prior to Cryopreservation....Pages 90-91
Front Matter....Pages 17-17
Serological Inhibition of Graft Versus Host Disease: Recent Results in 28 Patients with Leukemia....Pages 92-96
Graft-Versus-Host Disease: Immunobiological Aspects....Pages 97-101
T-Cell Phenotypes in Mixed Leukocyte Reactions and After Bone Marrow Transplantation: Are Ia-Antigen on T-Cells a Marker for GvH Reactions?....Pages 102-106
Monoclonal Antibody Therapy: “Model” Experiments with Toxin-Conjugated Antibodies in Mice and Rats....Pages 107-111
In Vitro Cytodestruction of Leukemic Cells in Human Bone Marrow Using a Cocktail of Monoclonal Antibodies....Pages 112-116
In Vitro Treatment with Monoclonal Antibody Prior to Autologous Bone Marrow Transplantation in Acute Lymphoblastic Leukemia....Pages 117-123
Immunological Classification of Acute Lymphatic Leukemia....Pages 124-125
Multimarker Analysis of Childhood Acute Lymphoblastic Leukemia (ALL): Heterogeneity of Cellular Phenotypes and Clinical Relevance of Immunological Defined ALL Subclasses....Pages 126-130
Morphological and Cytochemical Features of Adult T-Cell Lymphoma-Leukaemia....Pages 131-134
Activities and Specificities of N -Acetylneuraminyltransferases in Leukemic Cells....Pages 135-138
WT1: A Monoclonal Antibody Reactive with T-ALL but not with Other Leukemias....Pages 139-141
Dysfunctional Glucocorticoid Receptors in Acute Leukemia....Pages 142-145
Glucocorticoid-Induced Lysis of Various Subsets of Acute Lymphoblastic Leukemia....Pages 146-147
Epidemiology of HTLV-Associated Leukemia....Pages 148-155
Current Prospects for Clinical Care of Acute Leukemia....Pages 156-160
Front Matter....Pages 161-161
Viral Oncogenes and Cellular Prototypes....Pages 163-172
The Transforming Gene of Avian Acute Leukemia Virus MC29....Pages 173-177
Cellular onc Genes: Their Role as Progenitors of Viral onc Genes and Their Expression in Human Cells....Pages 178-185
The Biology of an Oncogene, Based Upon Studies on Neoplasia in Xiphophorus ....Pages 186-206
The Transforming Gene of Avian Myeloblastosis Virus (AMV): Nucleotide Sequence Analysis and Identification of Its Translational Product....Pages 207-213
Front Matter....Pages 161-161
DNA-Binding Ability of Transforming Proteins from Avian Erythroblastosis Virus and Mutant Avian Myelocytomatosis Virus, MC29, in Comparison with MC29 Wild Type....Pages 214-217
Lack of Expression of Cellular Homologues of Retroviral onc Genes in Bovine Tumors....Pages 218-221
Molecular Dissection of the Bovine Leukemia Virus Envelope Glycoprotein (BLV gp51) by a Monoclonal Antibody Study....Pages 222-226
Detection and Localization of a Phosphotyrosine-Containing onc Gene Product in Feline Tumor Cells....Pages 227-235
The Use of cDNA Cloning Techniques to Isolate Genes Activated in Tumour Cells....Pages 236-240
Cellular Transforming Genes in Cancer....Pages 241-246
The Human onc Gene c-myc : Structure, Expression, and Amplification in the Human Promyelocytic Leukemia Cell Line HL-60....Pages 247-254
Determination of Virulence Properties of Leukemia Viruses....Pages 255-260
Generation of Recombinant Murine Leukemia Viruses De Novo: An Alternative Model for Leukemogenesis....Pages 261-269
Expression of Retroviruses During Early Mouse Embryogenesis....Pages 270-274
Natural History of M-MSV Tumors in Mice Carrying Endogenized Moloney Leukemia Virus....Pages 275-279
Induction of Histiocytomas by Pristane Treatment of Mice Chronically Infected with Moloney Murine Leukemia Virus....Pages 280-281
Purification of a Reverse Transcriptase-like Protein from the Plasma of a Patient with Chronic Myelogenous Leukemia and Production of Monoclonal Antibodies....Pages 282-283
Detection of Group and Interspecies Reactivities in Mammalian C-Type Virus p30 Proteins and Corresponding Human Antigens....Pages 284-288
Papovaviruses and Human Tumors....Pages 289-292
Characterization of Proteins Induced by Herpesvirus saimiri : Comparative Immunoprecipitation and Analysis of Glycosylation....Pages 293-294
Structural Organization and Expression of the Epstein-Barr Virus Genome....Pages 295-296
Induction of Latent Epstein-Barr Virus Information by a Serum Factor....Pages 297-298
Thymic Nurse Cells and Radiation Leukemia Virus Induced Thymic Lymphomas in C57BL Mice....Pages 299-300
Construction and Characterization of Chromosomal DNA Libraries....Pages 301-310
Front Matter....Pages 161-161
Human T-Cell Leukemia-Lymphoma Virus (HTLV): A Progress Report....Pages 311-319
Early Events in the Suppression of Myeloid Leukemic Cells by Biological Regulators....Pages 320-326
Myeloid Leukemic Cell Differentiation Induced by Human Postendotoxin Serum and Vitamin Analogues....Pages 327-337
Effect of Colony-stimulating Factors on the Proteins Synthesized by Normal and Leukemic Myeloid Progenitor Cells....Pages 338-344
Molecular Properties of a Factor Inducing Differentiation in Murine Myelomonocytic Leukemic Cells....Pages 345-347
A Model Scheme for Human Hematopoietic Cell Differentiation as Determined by Multiple Markers of Leukemia-Lymphomas....Pages 348-350
Studies on the In Vitro Microenvironment in Man....Pages 351-354
Granulocyte-Macrophage Progenitor Cell Proliferation and Differentiation....Pages 355-357
Proliferation and Maturation of Hemopoietic Cells from Patients with Preleukemia and Aplastic Anemia in Agar and Diffusion Chamber Cultures....Pages 358-361
Persistent Deficiency of Myeloperoxidase and Lactoferrin in Granulopoietic Cells of Patients with Acute Leukemia....Pages 362-365
Studies on Normal B-Cells and Common Acute Lymphoblastic Leukemia Blast Cells Using a Colony Assay....Pages 366-368
Human Interleukin 2: Physiology, Biochemistry, and Pathophysiology in Lymphoblastic Leukemias and Immunodeficiency Syndromes....Pages 369-379
Studies of Myelopoiesis Using Monoclonal Antibodies and Variant Lines from the Promyeloid Cell Line HL60....Pages 380-383
Mechanisms for Induction of Differentiation in the Human Promyelocytic Cell Line HL-60....Pages 384-385
Differentiation of a Human Myeloid Cell Line (HL-60) Toward Granulocyte- and Macrophage-like Cells: Comparison of Cell Surface Antigen Expression....Pages 386-388
Transmission of Human T-Cell Leukemia Virus (HTLV) into Human Cord Blood T Cells....Pages 389-393
K 562 Cell Line in Plasma Clot Diffusion Chambers: Changes in Cell Surface Phenotype in Relationship to Culture Conditions....Pages 394-396
Antigen Expression on Normal and Leukaemic Erythroid Precursors....Pages 397-402
The Early Stage of Friend Virus Erythroleukemias: Mechanisms Underlying BPA-“independent” In Vitro Growth of BFU-E....Pages 403-406
Evidence for the Origin of Hodgkin and Sternberg-Reed Cells from a Newly Detected Small Cell Population....Pages 407-410
Front Matter....Pages 161-161
Hodgkin’s Disease Cell Lines: Characteristics and Biological Activities....Pages 411-417
Prelymphoma, Early Lymphoma, and Manifest Lymphoma in Immunosialadenitis (Sjögren’s Syndrome) — A Model of Lymphomagenesis....Pages 418-422
Front Matter....Pages 423-423
B-Cell Malignancies: Origin and Extent of Clonal Involvement....Pages 425-433
Transfection as an Approach to Understanding Membrane Glycoproteins....Pages 434-439
Structural and Functional Aspects of the T-Cell Differentiation Antigens T3, T6, and T8....Pages 440-446
Human Histocompatibility Antigens....Pages 447-453
Structure and Expression of Class I Genes of the Mouse Major Histocompatibility Complex....Pages 454-458
Presence of HTLV in a Subset of T Cells from an Infected Patient: Some Immunochemical Properties of the Infected Cells....Pages 459-461
Hybrids Between Human Cell Lines Belonging to Different Hematopoietic Pathways: Analysis of HLA and Myeloid Surface Antigens....Pages 462-465
Natural Killer Cells and Their Targets: Impact of Differentiation on Target Cell Susceptibility....Pages 466-469
Natural Cellular Defense Activities Against Tumors — Cytostasis and NK Activity....Pages 470-471
Structure and Function of the Transferrin Receptor — A Possible Role in the Recognition of Natural Killer Cells....Pages 472-474
NK and K Cells in Malignant Lymph Nodes....Pages 475-478
Contrasuppression, Class I Antigens, and Cancer Immunity....Pages 479-485
Inhibition of the Induction of Contrasuppression by Antisera Against Tumor-Associated Surface Antigens on Methylcholanthrene-induced Sarcomas....Pages 486-488
Dissection of a Unique Tumor-Specific Transplantation Antigen into Multiple Unique Independent Epitopes using Syngeneic T-Cell Lines....Pages 489-492
Detection of Antigen-(AKR MuLV gp70)-Specific Circulating Immune Complexes (CIC) in Mice with Lymphomas....Pages 493-497
Immunological Characterization of the Natural Antibodies to Human T-Cell Leukemia Virus in Human Sera....Pages 498-503
Front Matter....Pages 505-505
General Summary of the Meeting....Pages 507-513
Back Matter....Pages 515-518