Modern Trends in Human Leukemia IV: Latest Results in Clinical and Biological Research Including Pediatric Oncology

Front Matter....Pages I-XXV
Front Matter....Pages 1-1
The Relative Role of Viral Transformation and Specific Cytogenetic Changes in the Development of Murine and Human Lymphomas....Pages 3-10
On The Biology and Immunology of Hodgkin’s Disease....Pages 11-23
Front Matter....Pages 25-25
Chromosome Studies in Children and Adults with Leukemia....Pages 27-33
Myeloid Dysplasia: the Histopathology of Preleukemia....Pages 34-37
Progress in Acute Myeologenous Leukemia....Pages 38-44
VAPA 10 : A Treatment Program for Acute Myelocytic Leukemia....Pages 45-52
Rational Approaches to the Treatment of Leukemia....Pages 53-58
Treatment of Early Acute Nonlymphatic Leukemia with Low Dose Cytosine Arabinoside....Pages 59-62
A Phase I Study of Human Lymphoblastoid Interferon in Patients with Hematological Malignancies....Pages 63-67
Methods and Clinical Relevance of Terminal Deoxynucleotidyl Transferase Determination in Leukemic Cells....Pages 68-72
Quantitation of Chemotherapy-Induced Cytoreduction in Acute Leukemia....Pages 73-76
Intensive Therapy and Prognostic Factors in Acute Lymphoblastic Leukemia of Childhood: CCG 141....Pages 77-86
Treatment Strategy for Different Risk Groups in Childhood Acute Lymphoblastic Leukemia: A Report From the BFM Study Group....Pages 87-93
Recurrent Childhood Lymphocytic Leukemia: Outcome of Marrow Relapses After Cessation of Therapy....Pages 94-98
The Treatment of Primary Childhood Acute Lymphocytic Leukemia with Intermediate Dose Methotrexate....Pages 99-107
Present Problems in Management of Childhood Lymphoblastic Leukaemia: Experience from the Hospital for Sick Children, London....Pages 108-114
Different Therapy Protocols for High Risk and Standard Risk ALL in Childhood....Pages 115-120
T-Cell Acute Lymphoblastic Leukemia in Children....Pages 121-123
The Concept of GvHD-Suppression by In Vitro Treatment with Antisera....Pages 124-135
Bone Marrow Transplantation for the Treatment of Leukemia....Pages 136-138
Front Matter....Pages 25-25
Allogeneic Bone Marrow Transplantation for Acute Myeloid Leukemia in First Remission....Pages 139-142
Use of Erythrocyte Ghosts for Therapy....Pages 143-145
A Possible Biochemical Basis for the Use of Hyperthermia in the Treatment of Cancer and Virus Infection....Pages 146-148
Front Matter....Pages 149-149
The Implications of Nonrandom Chromosome Changes for Malignant Transformation....Pages 151-155
Regional Gene Mapping of Human Chromosomes Purified by Flow Sorting....Pages 156-159
The Different Origin of Primary and Secondary Chromosome Aberrations in Cancer....Pages 160-166
Insertion of New Genes into Bone Marrow Cells of Mice....Pages 167-170
Organization of the Methotrexate Resistant Mouse L5178YR Dihydrofolate Reductase Gene and Transformation of Human HCT-8 Cells by This Gene....Pages 171-174
Structure of the Lysozyme Gene and Expression in the Oviduct and Macrophages....Pages 175-178
Some Recent Trends in Studies of Human Lymphoid Cells: B-Cells, Epstein-Barr Virus, and Transformation....Pages 179-190
Epstein-Barr Virus: Its Site of Persistence and Its Role in the Development of Carcinomas....Pages 191-196
Episomal and Nonepisomal Herpesvirus DNA in Lymphoid Tumor Cell Lines....Pages 197-203
B-Lymphotropic Papovavirus (LPV)—Infections of Man?....Pages 204-206
Immunopathology of the X-Linked Lymphoproliferative Syndrome....Pages 207-214
Surface Characteristics of the U-937 Human Histiocytic Lymphoma Cell Line: Specific Changes During Inducible Morphologic and Functional Differentiation In Vitro....Pages 215-221
Enzyme Polymorphism as a Biochemical Cell Marker: Application to the Cellular Origin and Homogeneity of Human Macrophages and to the Classification of Malignant Lymphomas....Pages 222-224
Human Leukemic Lymphocytes — Biochemical Parameters of the Altered Differentiation Status....Pages 225-228
Lymphoproliferation and Heterotransplantation in Nude Mice: Tumor Cells in Hodgkin’s Disease....Pages 229-234
Front Matter....Pages 235-235
Genetic and Oncogenic Influences on Myelopoiesis....Pages 237-242
Acidic Isoferritins as Feedback Regulators in Normal and Leukemic Myelopoiesis....Pages 243-245
Front Matter....Pages 235-235
Assessment of Human Pluripotent Hemopoietic Progenitors and Leukemic Blast-Forming Cells in Culture....Pages 246-250
Proliferation and Maturation of Hemopoietic Cells in Adult Patients with Different Forms of Acute Leukemia and Chronic Myeloid Leukemia in Agar and Liquid Cultures....Pages 251-254
Cytological and Cytochemical Analysis of Plasma Clot Cultures and Peripheral Granulocytes Related to Long Term Survival in Childhood ALL and Cancer Patients Under Cytostatica Therapy....Pages 255-260
Maturation of Blast Cells in Acute Transformation of Chronic MyeloproliferativeSyndrome....Pages 261-264
Patterns of Cell Surface Differentiation of cALL Positive Leukemic Blast Cells in Diffusion Chamber Culture....Pages 265-267
Maturation of Human Peripheral Blood Leukemic Cells in Short-Term Culture....Pages 268-271
Regulator-Dependent Haemopoiesis and Its Possible Relevance to Leukemogenesis....Pages 272-275
Long-Term Culture of Normal and Leukemic Human Bone Marrow....Pages 276-288
Corticosteroid Dependence of Continuous Hemopoiesis In Vitro with Murine or Human Bone Marrow....Pages 289-293
Cloning Cells of the Immune System....Pages 294-295
Comparative Antigenic Phenotypes of Normal and Leukemic Hemopoietic Precursor Cells Analysed with a “Library” of Monoclonal Antibodies....Pages 296-304
Surface Antigens of Pluripotent and Committed Haemopoietic Stem Cells....Pages 305-308
Human Leucocyte Antigens....Pages 309-313
Immunologic Subsets in Human B-Cell Lymphomas in Relation to Normal B-Cell Development....Pages 314-319
Clones of Murine Functional T Cells....Pages 320-322
Marker Profiles of Leukemia-Lymphoma Cell Lines....Pages 323-325
Biochemical Characterization of an Antigen Associated with Acute Lymphoblastic Leukemia and Lymphocyte Precursors....Pages 326-328
Serologic Subtyping of cALL....Pages 329-331
Acute Myeloblastic Leukemia-Associated Antigens: Detection and Clinical Importance....Pages 332-337
Glycophorin A as an Erythroid Marker in Normal and Malignant Hematopoiesis....Pages 338-342
Front Matter....Pages 235-235
The Network Concept and Leukemia....Pages 343-344
Interpretation and In Vivo Relevance of Lymphocytotoxicity Assays....Pages 345-350
Acute Leukemia and Nonspecific Killer Cells....Pages 351-354
The Use of Bacteria as Markers of Leukemic Lymphocytes and for the Isolation of Natural Killer Cells....Pages 355-359
Receptor Mediated Murine Leukemogenesis: Monoclonal Antibody Induced Lymphoma Cell Growth Arrest....Pages 360-364
Effect of Bromodeoxyuridine on Endogenous Retrovirus Production in Differentiating Murine Lymphocytes....Pages 365-367
Modulation of Growth of Malignant Cells by Anti-Idiotypic Immunity....Pages 368-371
Thymic Nurse Cells: Intraepithelial Thymocyte Sojourn and Its Possible Relevance for the Pathogenesis of AKR lymphomas....Pages 372-376
Generation of Stable Antigen Loss Variants from Cloned Tumor Lines—An Example of Immunoadaptation During Metastasis....Pages 377-379
Front Matter....Pages 381-381
Transforming Genes of Retroviruses: Definition, Specificity, and Relation to Cellular DNA....Pages 383-396
A Cellular Protein Phosphorylated by the Avian Sarcoma Virus Transforming Gene Product....Pages 397-401
Correlated Loss of the Transformed Phenotype and pp60 src -Associated Protein Kinase Activity....Pages 402-404
The Transformation-Specific Protein pp60 src from an Avian Sarcoma Virus....Pages 405-408
Proteolytic Processing of Avian and Simian Sarcoma and Leukemia Viral Proteins....Pages 409-413
Control of Protein Synthesis. Phosphorylation and Dephosphorylation of Eukaryotic Peptide Initiation Factor 2....Pages 414-416
Characterization of the Hematopoietic Target Cells of Defective Avian Leukemia Viruses by Velocity Sedimentation and Density Gradient Centrifugation Analyses....Pages 417-423
PRCII, a Representative of a New Class of Avian Sarcoma Viruses....Pages 424-428
Identification of the Avian Myeloblastosis Virus Genome....Pages 429-431
Genetics of Leukemogenesis by Avian Leukosis Viruses....Pages 432-438
Avian Lymphoid Leukosis is Correlated with the Appearance of Discrete New RNAs Containing Viral and Cellular Genetic Information....Pages 439-444
Front Matter....Pages 381-381
The Molecular Basis of Avian Retrovirus-Induced Leukemogenesis....Pages 445-451
Studies of the Association of Leukemogenic and Oncogenic Properties in Avian Leukemia Viruses....Pages 452-454
Genetic Approaches Toward Elucidating the Mechanisms of Type-C Virus-Induced Leukemia....Pages 455-459
The Long Terminal Repeat of Moloney Sarcoma Provirus Enhances Transformation....Pages 460-466
Ontogeny of Abelson Murine Leukemia Virus Target Cells....Pages 467-471
Structural and Functional Studies of the Friend Spleen Focus-Forming Virus: Structural Relationship of SFFV to Dualtropic Viruses and Molecular Cloning of a Biologically Active Subgenomic Fragment of SFFV DNA....Pages 472-478
Enhancing Effect of Murine Leukemia Virus on Fibroblast Transformation by Normal BALB/C Mouse DNA Fragments....Pages 479-482
Role of Viruses in the Etiology of Naturally Occurring Feline Leukemia....Pages 483-487
Relationship of the Feline Oncornavirus Associated Cell Membrane Antigen to a Feline Sarcoma Virus Encoded Polyprotein....Pages 488-491
Feline Leukemia Virus Nonproducer Lymphosarcomas of Cats as a Model for the Etiology of Human Leukemias....Pages 492-494
Genomic Integration of Bovine Leukemia Provirus and Lack of Viral RNA Expression in the Target Cells of Cattle with Different Responses to BLV Infection....Pages 495-497
Natural Antibodies to BLV gp51 Are Reactive Against the Carbohydrate Moiety of the Glycoprotein....Pages 498-501
Regulation of Human T-Cell Proliferation: T-Cell Growth Factor and Isolation of a New Class of Type-C Retroviruses from Human T-Cells....Pages 502-514
Characterization by Nucleic Acid Hybridization of HTLV, a Novel Retrovirus from Human Neoplastic T-Lymphocytes....Pages 515-516
Different Frequency Classes of Sequences in Heterogeneous Nuclear RNA of Normal Promyelocytes and Lymphoblasts and of Leukemic Blast Cells of Circulating Blood and of the HL60 Line....Pages 517-519
Characterization of Antigens in SSV Nonproducer Cells....Pages 520-523
Viral Gene Expression in Cells Transformed by Simian Sarcoma Virus, an Infectious Primate Type C Retrovirus....Pages 524-526
Cell Fusion as a Tool for the Detection of Viral Footprints in Childhood Leukemia....Pages 527-529
ELISA for the Detection of Antigens Cross-Reacting with Primate C-Type Viral Proteins (p30, gp70) in Human Leukemic Sera....Pages 530-536
Radiation-Induced Murine Leukemias and Endogenous Retroviruses: The Time Course of Viral Expression....Pages 537-540
Front Matter....Pages 381-381
Retrovirus Particle Production in Three of Four Human Teratocarcinoma Cell Lines....Pages 541-544
Front Matter....Pages 545-545
General Summary....Pages 547-549
Back Matter....Pages 551-557