Modern Trends in Human Leukemia III: Newest Results in Clinical and Biological Research

Front Matter....Pages I-XXII
Front Matter....Pages 1-1
Memorial Tribute to Dr. Frederick Stohlman....Pages 3-6
Cellular and Virological Studies Directed to the Pathogenesis of the Human Myelogenous Leukemias....Pages 7-24
Treatment of Childhood Acute Lymphocytic Leukemia....Pages 25-33
Front Matter....Pages 35-35
Epidemiology of Leukemia....Pages 37-41
Chromosome Abnormalities in Leukemia....Pages 43-52
Use of Glucose-6-Phosphate Dehydrogenase Markers to Study Human Myeloproliferative Disorders....Pages 53-58
Histopathology of Bone Marrow in Human Chronic Leukemias....Pages 59-70
Bone Marrow Transplantation in Acute Leukemia: Current Status and Future Directions....Pages 71-78
Impact of Specific Immunotherapy in Acute Myelocytic Leukemia....Pages 79-87
Treatment of Adult Acute Myeloblastic Leukemia....Pages 89-92
Prediction of Therapeutic Response in Acute Myelocytic Leukemia....Pages 93-98
Prognostic Factors in Adult Acute Lymphoblastic Leukemia....Pages 99-105
Ultrastructure and Cell Marker Studies in Lymphoproliferative Disorders....Pages 107-113
Intermediate Dose Methotrexate (IDM) in Childhood Acute Lymphocytic Leukemia (ALL)....Pages 115-123
Marrow Terminal Deoxynucleotidyl Transferase Activity in Adult Acute Leukemia....Pages 125-130
Clinical Significance of TdT, Cell Surface Markers and CFU-C in 297 Patients with Hematopoietic Neoplasias....Pages 131-138
Biochemical Determinants for Antileukemia Drug Treatment....Pages 139-143
Biological and Clinical Effects of a Partially Thiolated Polycytidylic Acid (MPC): A Potent Inhibitor of DNA Synthesis in RNA Tumor Viruses....Pages 145-155
Summary of Clinical Poster Sessions....Pages 157-162
Progress in Acute Leukemia 1975–1978....Pages 163-168
Front Matter....Pages 169-169
Regulatory Interactions in Normal and Leukemic Myelopoiesis....Pages 171-180
Leukemic Inhibition of Normal Hematopoiesis....Pages 181-190
Clonal Diseases of the Myeloid Stem Cell Systems....Pages 191-197
Intramedullary Influences on in Vitro Granulopoiesis in Human Acute Myeloid Leukemia....Pages 199-204
Analysis of Myeloproliferative Disorders Using Cell Markers in Culture....Pages 205-210
Morphologic Characteristics of Human Blood Cells in Semi-Solid Marrow Cultures....Pages 211-215
Differentiation Ability of Peripheral Blood Cells from Patients with Acute Leukemia or Blast Crisis in Chronic Myelocytic Leukemia....Pages 217-221
Modification of the Proliferative and Differentiation Capacity of Stem Cells Following Treatment with Chemical and Viral Leukemogens....Pages 223-229
Characterization of Myelomonocytic Leukemia Cells Induced by in vitro Infection of Bone Marrow with FLV....Pages 231-235
Epstein Barr Virus (EBV) and Complement (C 3 ) Interactions With Human Lymphoid Cells....Pages 237-238
Front Matter....Pages 239-239
Anatomy of the RNA and Gene Products of MC29 and MH2, two Defective Avian Tumor Viruses Causing Acute Leukemia and Carcinoma: Evidence for a New Class of Transforming Genes....Pages 241-260
Studies on the Structure and Function of the Avian Sarcoma Virus Transforming Gene Product....Pages 261-269
The in vitro Translation of Rous Sarcoma Virus RNA and Function of the Viral Protein During the Viral Replication....Pages 271-276
Regulation of Translation of Eukaryotic Virus mRNAs....Pages 277-281
Control of Eukaryotic Protein Synthesis by Phosphorylation....Pages 283-290
Cell-free Protein Synthesis and Interferon Action: Protein Kinase(s) and an Oligonucleotide Effector, pppA2′p5′A2′p5′A....Pages 291-294
Alterations in Translational Control Mechanisms in Friend Erythroleukemic Cells During DMSO Induced Differentiation....Pages 295-301
Inhibition of Polypeptide Chain Initiation by Inducers of Erythroid Differentiation in Friend Erythroleukemic Cells....Pages 303-306
Possible Role of the Friend Virus Life Cycle in Differentiating Friend Leukemia Cells Treated with Interferon....Pages 307-311
Genetic Analysis of Human Cell Surface Structures....Pages 313-317
Front Matter....Pages 239-239
Effect of Vitamin A on Plasminogen Activator Synthesis by Chick Embryo Fibroblasts....Pages 319-323
The Molecular Biology of Differentiation and Transformation: An Emerging Field Theory....Pages 325-332
Front Matter....Pages 333-333
Leukemic Cell Phenotypes in Man: Relationship to ‘Target’ Cells for Leukemogenesis and Differentiation Linked Gene Expression....Pages 335-345
Characterization of Antigens on Acute Lymphoblastic Leukemias....Pages 347-352
Common All Associated Antigen from Cell Surface and Serum: Molecular Properties and Clinical Relevance....Pages 353-363
Monoclonal Antibodies to Human Cell Surface Antigens....Pages 365-368
Elicitation of Anti-Leukemia Cytotoxic Responses....Pages 369-376
Histocompatibility Antigens and T Cell Responses to Leukemia Antigens....Pages 377-379
T Cell Function in Myelogenous Leukemia....Pages 381-384
Recognition of Simian Sarcoma Virus Antigen by Human Sera....Pages 385-394
Studies of Human Serological Reactivity with Type C Virus and Viral Proteins....Pages 395-399
A Search for Type-C Virus Expression in Man....Pages 401-405
Tumor Cell Mediated Degradation In Vitro of Antitumor Antibodies....Pages 407-412
Evidence Supporting a Physiological Role for Endogenous C-Type Virus in the Immune System....Pages 413-415
Immunological Aspects....Pages 417-420
Front Matter....Pages 421-421
Introduction to Oncogenesis by RNA Tumor Viruses....Pages 423-427
Mechanism of Leukemogenesis and of Target Cell Specificity by Defective Avian Leukemia Viruses: A Hypothesis....Pages 429-438
Infectious Leukemias in Domestic Animals....Pages 439-444
Biochemical and Epidemiological Studies on Bovine Leukemia Virus (BLV)....Pages 445-452
Leukemia Specific Antigens: FOCMA and Immune Surveillance....Pages 453-467
Front Matter....Pages 421-421
A Single Genetic Locus Determines the Efficacy of Serum Therapy Against Murine Adenocarcinoma 755a....Pages 469-481
The Search for Infectious Viral DNA in Human Leukemic Cells....Pages 483-486
Infection of Mouse Bone Marrow Cells with Abelson Murine Leukemia Virus and Establishment of Producer Cell Lines....Pages 487-490
Cocultivation as a Tool for the Detection of Oncoviruses in Childhood Leukemia....Pages 491-496
Evidence for the Presence of an Oncornaviral Reverse Transcriptase in an Orbital Tumor Associated to Acute Myelomonocytic Leukemia in Children: Biochemical and Immunological Characterization of the Enzyme....Pages 497-500
Inactivation and Lysis of Oncornaviruses by Human and Primate Complement....Pages 501-503
Front Matter....Pages 505-505
The Role of Gene Rearrangement in Evolution....Pages 507-511
Bacterial Transposons....Pages 513-521
The Virus-Cell Gene Balance Model of Cancerogenesis....Pages 523-527
Comparative Analysis of RNA Tumor Virus Genomes....Pages 529-552
Detection of Integrated Type-C Viral DNA Fragments in Two Primates (Human and Gibbon) by the Restriction Enzyme Blotting Technique....Pages 553-560
Genetic Transmission of Moloney Leukemia Virus: Mapping of the Chromosomal Integration Site....Pages 561-568
Integration Sites for Moloney Murine Leukemia Virus DNA in Infected Mouse Cells....Pages 569-573
Release of Particle Associated RNA Dependent DNA Polymerases by Primary Chicken and Quail Embryo Cells....Pages 575-579
Pluripotent Teratocarcinoma — Simian Virus 40 Transformed Mouse Fibroblasts Somatic Cell Hybrids....Pages 581-585
Front Matter....Pages 587-587
Summary of Meeting on Modern Trends in Human Leukemia....Pages 589-592
Back Matter....Pages 593-602