Modern Pharmacology With Clinical Applications

Cover......Page 1
LinkToy : )~......Page 0
Preface......Page 2
Table of Contents......Page 3
Section I General Principles of Pharmacology......Page 5
1 Progress in Therapeutics......Page 7
2 Mechanisms of Drug Action......Page 14
3 Drug Absorption and Distribution......Page 24
4 Metabolism and Excretion of Drugs......Page 38
5 Pharmacokinetics......Page 52
6 Drug Metabolism and Disposition in Pediatric and Gerontological Stages of Life......Page 61
7 Principles of Toxicology......Page 68
8 Contemporary Bioethical Issues in Pharmacology and Pharmaceutical Research......Page 78
Section II Drugs Affecting the Autonomic Nervous System......Page 86
9 General Organization and Functions of the Nervous System......Page 88
10 Adrenomimetic Drugs......Page 101
11 Adrenoceptor Antagonists......Page 114
12 Directly and Indirectly ActingCholinomimetics......Page 126
13 Muscarinic Blocking Drugs......Page 139
14 Ganglionic Blocking Drugs and Nicotine......Page 147
Section III Drugs Affecting the Cardiovascular System......Page 155
15 Pharmacological Management of Chronic Heart Failure......Page 157
16 Antiarrhythmic Drugs......Page 166
17 Antianginal Drugs......Page 202
18 The Renin-Angiotensin Aldosterone System and Other Vasoactive Substances......Page 212
19 Calcium Channel Blockers......Page 224
20 Antihypertensive Drugs......Page 231
21 Diuretic Drugs......Page 245
22 Anticoagulant, Antiplatelet, and Fibrinolytic (Thrombolytic) Drugs......Page 262
23 Hypocholesterolemic Drugs and Coronary Heart Disease......Page 274
Section IV Drugs Affecting the Central Nervous System......Page 285
24 Introduction to Central Nervous System Pharmacology......Page 287
25 General Anesthesia: Intravenousand Inhalational Agents......Page 297
26 Opioid and Nonopioid Analgesics......Page 316
27 Local Anesthetics......Page 336
28 Agents Affecting Neuromuscular Transmission......Page 344
29 Central Nervous System Stimulants......Page 354
30 Sedative–Hypnotic and Anxiolytic Drugs......Page 361
31 Drugs Used in Neurodegenerative Disorders......Page 370
32 Antiepileptic Drugs......Page 380
33 Drugs Used in Mood Disorders......Page 391
34 Antipsychotic Drugs......Page 403
35 Contemporary Drug Abuse......Page 412
Section V Therapeutic Aspects of Inflammatory and Selected Other Clinical Disorders......Page 427
36 Antiinflammatory and Antirheumatic Drugs......Page 429
37 Drugs Used in Gout......Page 447
38 Histamine and Histamine Antagonists......Page 455
39 Drugs Used in Asthma......Page 464
40 Drugs Used in Gastrointestinal Disorders......Page 476
41 Drugs Used in Dermatological Disorders......Page 490
42 Drugs for the Control of Supragingival Plaque......Page 505
Section VI Chemotherapy......Page 513
43 Introduction to Chemotherapy......Page 515
44 Synthetic Organic Antimicrobials: Sulfonamides, Trimethoprim, Nitrofurans, Quinolones, Methenamine......Page 521
45 B-Lactam Antibiotics......Page 532
46 Aminoglycoside Antibiotics......Page 544
47 Tetracyclines, Chloramphenicol, Macrolides, and Lincosamides......Page 550
48 Bacitracin, Glycopeptide Antibiotics, and the Polymyxins......Page 558
49 Drugs Used in Tuberculosis and Leprosy......Page 563
50 Antiviral Drugs......Page 573
51 Therapy of Human Immunodeficiency Virus......Page 590
52 Antifungal Drugs......Page 602
53 Antiprotozoal Drugs......Page 612
54 Anthelmintic Drugs......Page 627
55 The Rational Basis for Cancer Chemotherapy......Page 636
56 Antineoplastic Agents......Page 645
57 Immunomodulating Drugs......Page 664
58 Gene Therapy......Page 673
Section VII Drugs Affecting the Endocrine System......Page 682
59 Hypothalamic and Pituitary Gland Hormones......Page 684
60 Adrenocortical Hormones and Drugs Affecting the Adrenal Cortex......Page 693
61 Estrogens, Progestins, and Specific Estrogen Receptor Modulators (Serms)......Page 711
62 Uterine Stimulants and Relaxants......Page 723
63 Androgens, Antiandrogens, and Anabolic Steroids......Page 731
64 Drugs Used in the Treatment of Erectile Dysfunction......Page 742
65 Thyroid and Antithyroid Drugs......Page 749
66 Parathyroid Hormone, Calcitonin, Vitamin D, and Other Compounds Related to Mineral Metabolism......Page 761
67 Insulin and Oral Drugs for Diabetes Mellitus......Page 770
68 Vitamins......Page 784
69 Herbal Medicine......Page 792
Contributing Authors......Page 808