مشخصات کتاب

Modern Biopharmaceuticals: Design, Development and Optimization

ویرایش:  
 
سری:  
ISBN (شابک) : 9783527311842, 9783527620982 
ناشر: Wiley-Blackwell 
سال نشر: 2005 
تعداد صفحات: 2012 
زبان: English 
فرمت فایل : PDF (درصورت درخواست کاربر به PDF، EPUB یا AZW3 تبدیل می شود) 
حجم فایل: 196 مگابایت 

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توضیحاتی درمورد کتاب به خارجی

The biopharmaceutical market has come along way since 1982 when the first biopharmaceutical product, recombinant human insulin, was launched.
Over 120 such products are currently being marketed around the world including nine blockbuster drugs. The global market for biopharmaceuticals, which is currently valued at US$41 billion, has been growing at an impressive compound annual growth rate of 21% over the previous five years.

With over one third of all pipe-line products in active development are biopharmaceuticals, this segment is set to continue outperforming the total pharmaceutical market and could easily reach US$100 billion by the end of this decade.Content:
Chapter 1 Beginning to Understand the End of the Chromosome (pages 36–48): Thomas R. Cech
Chapter 2 The Role of Pharmacogenetics/Pharmacogenomics in Drug Development and Regulatory Review: Current Status (pages 49–70): Shiew?Mei Huang and Lawrence J. Lesko
Chapter 3 Large?scale Detection of Genetic Variation: The Key to Personalized Medicine (pages 71–98): Joerg Geistlinger and Peter Ahnert
Chapter 4 A Systems Biology Approach to Target Identification and Validation for Human Chronic Disease Drug Discovery (pages 99–125): Bonnie E. Gould Rothberg, Carol E. A. Pena and Jonathan M. Rothberg
Chapter 5 The Development of Herceptin®: Paving the Way for Individualized Cancer Therapy (pages 127–150): Thorsten S. Gutjahr and Carsten Reinhardt
Chapter 6 Adenovirus?based Gene Therapy: Therapeutic Angiogenesis with Adenovirus 5 Fibroblast Growth Factor?4 (Ad5FGF?4) in Patients with Chronic Myocardial Ischemia (pages 151–181): Michael McCaman, Francisco J. Castillo, Farah Fawaz, Yasushi Ogawa, Erik Whiteley, Elisabeth Lehmberg, Mei Tan, Jacob Kung, Bruce Mann, Erno Pungor and Gabor M. Rubanyi
Chapter 7 MIDGE Vectors and dSLIM Immunomodulators: DNA?based Molecules for Gene Therapeutic Strategies (pages 183–211): Manuel Schmidt, Barbara Volz and Burghardt Wittig
Chapter 8 Nonprotein?coding RNAs and their Potential as Biopharmaceuticals (pages 213–227): Maciej Szymanski, Jan Barciszewski and Volker A. Erdmann
Chapter 9 Double?stranded Decoy Oligonucleotides as new Biopharmaceuticals (pages 229–241): Andreas H. Wagner and Heiko E. Von der Leyen
Chapter 10 Rational siRNA Design for RNA Interference: Optimizations for Therapeutic Use and Current Applications (pages 243–268): Anastasia Khvorova, Queta Boese and William S. Marshall
Chapter 11 The First Cloned Human Embryo: An Unlimited Source of Stem Cells for Therapeutic Cloning (pages 269–282): Woo Suk Hwang, Byeong Chun Lee, Sung Keun Kang and Shin Yong Moon
Chapter 12 Myocardial Regeneration Strategies using Human Embryonic Stem Cells (pages 283–304): Izhak Kehat, Oren Caspi and Lior Gepstein
Chapter 13 Gene and Cell?based Therapies for Cardiovascular Disease (pages 305–324): Abeel A. Mangi
Chapter 14 Spheramine®: A Cell Therapeutic Approach to Parkinson's Disease (pages 325–351): Elke Reissig, Hermann Graf and Friedrich?Joachim Kapp
Chapter 15 Applying Human Cells to Organogenesis and Transplantation (pages 353–373): Benjamin Dekel and Yair Reisner
Chapter 1 Mechanisms of Serine Proteinase Activation: Insights for the Development of Biopharmaceuticals for Coagulation and Fibrinolysis (pages 376–393): Rainer Friedrich
Chapter 2 Application of the Principle of Polyvalency to Protease Inhibition (pages 395–417): Luis Moroder
Chapter 3 A New Technology Standard for Safety and Efficacy in Factor VIII Replacement Therapy: Designing an Advanced Category rFVIII Concentrate (pages 419–449): Norbert Riedel and Friedrich Dorner
Chapter 4 Biopharmaceutical Drugs from Natural Sources (pages 451–496): David J. Newman, Gordon M. Cragg and Barry R. O'Keefe
Chapter 5 Biopharmaceuticals as Targeting Vehicles for In situ Radiotherapy of Malignancies (pages 497–535): Raymond M. Reilly
Chapter 6 New Directions in Tumor Therapy ?Amino Acid Depletion with GlutaDON® as Treatment for Cancer (pages 537–547): Rolf Kalhammer and Natarajan Sethuraman
Chapter 7 AIDS Gene Therapy: A Vector Able to Selectively Destroy Latently HIV?1?infected Cells (pages 549–568): Francisco Luque Vaquez and Ricardo Oya
Chapter 8 Combinatorial RNA?based Therapies for HIV?1 (pages 569–580): Kevin V. Morris and John J. Rossi
Chapter 1 Design of Modern Biopharmaceuticals by Ultra?high?throughput Screening and Directed Evolution (pages 582–603): Markus Rarbach, Wayne M. Coco, Andre Koltermann, Ulrich Kettling and Manfred Eigen
Chapter 2 Learning from Viruses: High?throughput Cloning using the Gateway System to Transfer Genes without Restriction Enzymes (pages 605–620): Jonathan D. Chesnut
Chapter 3 Target Validation: An Important Early Step in the Development of Novel Biopharmaceuticals in the Post?genomic Era (pages 621–647): Christoph P. Bagowski
Chapter 4 Genetically Modified Mice in Medical and Pharmaceutical Research (pages 649–660): Cord Brakebusch
Chapter 5 An NIH Model Organism for Biopharmaceutical and Biomedical Research: The Lower Eukaryote Dictyostelium discoideum (pages 661–693): Thomas Winckler, Ilse Zundorf and Theodor Dingermann
Chapter 6 Releasing the Spring: Cofactor? and Substrate?assisted Activation of Factor IXa (pages 695–702): Hans Brandstetter and Katrin Sichler
Chapter 7 Accelerating Diagnostic Product Development Process with Molecular Rational Design and Directed Evolution (pages 703–719): Harald Sobek, Rainer Schmuck and Zhixin Shao
Chapter 1 Manufacture of Recombinant Biopharmaceutical Proteins by Cultivated Mammalian Cells in Bioreactors (pages 723–759): Florian M. Wurm
Chapter 2 Alternative Strategies and New Cell Lines for High?level Production of Biopharmaceuticals (pages 761–777): Thomas Rose, Karsten Winkler, Elisabeth Brundke, Ingo Jordan and Volker Sandig
Chapter 3 PER.C6® Cells for the Manufacture of Biopharmaceutical Proteins (pages 779–807): Chris Yallop, John Crowley, Johanne Cote, Kirsten Hegmans?Brouwer, Fija Lagerwerf, Rodney Gagne, Jose Coco Martin, Nico Oosterhuis, Dirk?Jan Opstelten and Abraham Bout
Chapter 4 Use of the Glutamine Synthetase (GS) Expression System for the Rapid Development of Highly Productive Mammalian Cell Processes (pages 809–832): John R. Birch, David O. Mainwaring and Andrew J. Racher
Chapter 5 Biopharmaceuticals Derived from Transgenic Plants and Animals (pages 833–892): Julio Baez
Chapter 6 Production of Recombinant Proteins in Plants (pages 893–917): Victor Klimyuk, Sylvestre Marillonnet, Jorg Knablein, Michael McCaman and Yuri Gleba
Chapter 7 Humanized Glycosylation: Production of Biopharmaceuticals in a Moss Bioreactor (pages 919–929): Gilbert Gorr and Sabrina Wagner
Chapter 8 ExpressTec: High?level Expression of Biopharmaceuticals in Cereal Grains (pages 931–947): Ning Huang and Daichang Yang
Chapter 9 Biopharmaceutical Production in Cultured Plant Cells (pages 949–965): Stefan Schillberg, Richard M. Twyman and Rainer Fischer
Chapter 10 Producing Biopharmaceuticals in the Desert: Building an Abiotic Stress Tolerance in Plants for Salt, Heat, and Drought (pages 967–994): Shimon Gepstein, Anil Grover and Eduardo Blumwald
Chapter 11 The First Biopharmaceutical from Transgenic Animals: ATryn® (pages 995–1020): Yann Echelard, Harry M. Meade and Carol A. Ziomek
Chapter 12 Producing Modern Biopharmaceuticals: The Bayer HealthCare Pharma Experience with a Range of Expression Systems (pages 1021–1032): Heiner Apeler
Chapter 13 Advanced Expression of Biopharmaceuticals in Yeast at Industrial Scale: The Insulin Success Story (pages 1033–1044): Asser Sloth Andersen and Ivan Diers
Chapter 14 Baculovirus?based Production of Biopharmaceuticals using Insect Cell Culture Processes (pages 1045–1062): Wilfried Weber and Martin Fussenegger
Chapter 15 Robust and Cost?effective Cell?free Expression of Biopharmaceuticals: Escherichia Coli and Wheat Embryo (pages 1063–1081): Luke Anthony Miles
Chapter 16 Contract Manufacturing of Biopharmaceuticals Including Antibodies or Antibody Fragments (pages 1083–1101): J. Carsten Hempel and Philipp N. Hess
Chapter 1 Thirty Years of Monoclonal Antibodies: A Long Way to Pharmaceutical and Commercial Success (pages 1104–1145): Uwe Gottschalk and Kirsten Mundt
Chapter 2 Modern Antibody Technology: The Impact on Drug Development (pages 1147–1186): Simon Moroney and Andreas Pluckthun
Chapter 3 Molecular Characterization of Autoantibody Responses in Autoimmune Diseases: Implications for Diagnosis and Understanding of Autoimmunity (pages 1187–1209): Constanze Breithaupt
Chapter 4 Molecular Imaging and Applications for Pharmaceutical R&D (pages 1211–1241): Joke G. Orsel and Tobias Schaeffter
Chapter 5 Design and Development of Probes for In vivo Molecular and Functional Imaging of Cancer and Cancer Therapies by Positron Emission Tomography (PET) (pages 1243–1270): Eric O. Aboagye
Chapter 6 Ligand?based Targeting of Disease: From Antibodies to Small Organic (Synthetic) Ligands (pages 1271–1299): Michela Silacci and Dario Neri
Chapter 7 Ultrasound Theranostics: Antibody?based Microbubble Conjugates as Targeted In vivo Contrast Agents and Advanced Drug Delivery Systems (pages 1301–1324): Andreas Briel, Michael Reinhardt, Mathias Maurer and Peter Hauff
Chapter 8 Development of Multi?marker?based Diagnostic Assays with the ProteinChip® System (pages 1325–1342): Andreas Wiesner
Chapter 9 Early Detection of Lung Cancer: Metabolic Profiling of Human Breath with Ion Mobility Spectrometers (pages 1343–1358): Jorg Ingo Baumbach, Wolfgang Vautz, Vera Ruzsanyi and Lutz Freitag
Chapter 1 Advanced Drug Delivery Systems for Biopharmaceuticals (pages 1360–1391): Gesine E. Hildebrand and Stephan Harnisch
Chapter 2 Poly(ethylene) Glycol Conjugates of Biopharmaceuticals in Drug Delivery (pages 1393–1418): Michael D. Bentley, Mary J. Bossard, Kevin W. Burton and Tacey X. Viegas
Chapter 3 Novel Vaccine Adjuvants Based on Cationic Peptide Delivery Systems (pages 1419–1443): Karen Lingnau, Christoph Klade, Michael Buschle and Alexander Von Gabain
Chapter 4 The Evolving Role of Oralin™ (Oral Spray Insulin) in the Treatment of Diabetes using a Novel Rapid Mist™ Diabetes Management System (pages 1445–1461): Pankaj Modi
Chapter 5 Improvement of Intestinal Absorption of Peptide and Protein Biopharmaceuticals by Various Approaches (pages 1463–1486): Akira Yamamoto
Chapter 6 DNA Vaccine Delivery from Poly(ortho ester) Microspheres (pages 1487–1506): Chun Wang, Herman N. Eisen, Robert Langer and Jorge Heller
Chapter 7 Liposomal In vivo Gene Delivery (pages 1507–1519): Shigeru Kawakami, Fumiyoshi Yamashita and Mitsuru Hashida
Chapter 8 Programmed Packaging: A New Drug Delivery System and its Application to Gene Therapy (pages 1521–1536): Kentaro Kogure, Hidetaka Akita, Hiroyuki Kamiya and Hideyoshi Harashima
Chapter 9 Bionanotechnology and its Role to Improve Biopharmaceuticals (pages 1537–1554): Oliver Kayser
Chapter 1 Analytics in Quality Control and In vivo (pages 1556–1579): Michael Hildebrand
Chapter 2 Design, Development and Optimization: Crystal Structures of Microsomal Cytochromes P450 (pages 1581–1602): Dijana Matak Vinkovic, Sheena Whyte, Harren Jhoti, Jose Cosme and Pamela A. Williams
Chapter 3 Mettox™: A Suite of Predictive In silico and In vitro Assays for Metabolic and Genotoxicological Profiling of Preclinical Drug Candidates (pages 1603–1636): Michael Murray
Chapter 4 Considerations for Developing Biopharmaceuticals: FDA Perspective (pages 1637–1667): Kurt Brorson, Patrick G. Swann, Janice Brown, Barbara Wilcox and Marjorie A. Shapiro
Chapter 5 The Regulatory Environment for Biopharmaceuticals in the EU (pages 1669–1708): Axel F. Wenzel and Carina E. A. Sonnega
Chapter 1 Healthcare Trends and their Impact on the Biopharmaceutical Industry: Biopharmaceuticals Come of Age (pages 1710–1740): Alexander Moscho, Markus A. Schafer and Kristin Yarema
Chapter 2 mondoBIOTECH: The Swiss biotech BOUTIQUE (pages 1741–1754): Dorian Bevec and Fabio Cavalli
Chapter 3 G?CSF and Bioequivalence: The Emergence of Healthcare Economics (pages 1755–1769): James Harris
Chapter 4 Bioinformatics: From Peptides to Profiled Leads (pages 1771–1801): Paul Wrede and Matthias Filter
Chapter 5 Engineering and Overproduction of Polyketide Natural Products (pages 1803–1832): Martha Lovato Tse and Chaitan Khosla

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