Models for Assessing Drug Absorption and Metabolism

Front Matter....Pages i-xxii
General Principles in the Characterization and Use of Model Systems for Biopharmaceutical Studies....Pages 1-11
Methods for Evaluating Intestinal Permeability and Metabolism in Vitro ....Pages 13-34
Cultured Intestinal Epithelial Cell Models....Pages 35-50
Intestinal Rings and Isolated Intestinal Mucosal Cells....Pages 51-66
Models of Drug Absorption in Situ and in Conscious Animals....Pages 67-84
Model Systems for Intestinal Lymphatic Transport Studies....Pages 85-102
Buccal Tissues and Cell Culture....Pages 103-113
Isolated Hepatocytes....Pages 115-120
Cultured Rat Hepatocytes....Pages 121-159
Isolated Perfused Liver....Pages 161-192
Isolated Renal Brush Border and Basolateral Membrane Vesicles and Cultured Renal Cells....Pages 193-210
Use of an Isolated Perfused Kidney to Assess Renal Clearance of Drugs....Pages 211-238
Brain Microvessel Endothelial Cell Culture Systems....Pages 239-258
Methods to Study Drug Transport in Isolated Choroid Plexus Tissue and Cultured Cells....Pages 259-283
Brain Perfusion Systems for Studies of Drug Uptake and Metabolism in the Central Nervous System....Pages 285-307
 In Vitro Nasal Models....Pages 309-323
Models for Investigation of Peptide and Protein Transport across Cultured Mammalian Respiratory Epithelial Barriers....Pages 325-346
Drug Transport across Xenopus Alveolar Epithelium in Vitro ....Pages 347-359
 In Situ and in Vivo Methods for Pulmonary Delivery....Pages 361-374
 In Vitro Viable Skin Model....Pages 375-386
Isolated Perfused Porcine Skin Flap Systems....Pages 387-407
Vaginal Epithelial Models....Pages 409-424
Ocular Epithelial Models....Pages 425-436
Back Matter....Pages 437-444