Mitochondrial Pathogenesis: From Genes and Apoptosis to Aging and Disease

Front Matter....Pages N2-ix
Overview....Pages 1-6
Mitochondrial Genome Single Nucleotide Polymorphisms and Their Phenotypes in the Japanese....Pages 7-20
Mitochondrial DNA Variation in the Aboriginal Populations of the Altai-Baikal Region....Pages 21-35
Mitochondrial ALDH2 Deficiency as an Oxidative Stress....Pages 36-44
Mitochondrial Reactive Oxygen Species Generation and Calcium Increase Induced by Visible Light in Astrocytes....Pages 45-56
Radical Metabolism Is Partner to Energy Metabolism in Mitochondria....Pages 57-60
Mitochondrial Nucleoid and Transcription Factor A....Pages 61-68
Regulation of Mitochondrial Transcription Factor A Expression by High Glucose....Pages 69-77
Regulation and Role of the Mitochondrial Transcription Factor in the Diabetic Rat Heart....Pages 78-85
The Mitochondrial Production of Reactive Oxygen Species in Relation to Aging and Pathology....Pages 86-100
Biological Significance of the Defense Mechanisms against Oxidative Damage in Nucleic Acids Caused by Reactive Oxygen Species....Pages 101-111
Mitochondrial Swelling and Generation of Reactive Oxygen Species Induced by Photoirradiation Are Heterogeneously Distributed....Pages 112-122
Mitochondrial Dysfunction via Disruption of Complex II Activity during Iron Chelation—Induced Senescence-like Growth Arrest of Chang Cells....Pages 123-132
Mitochondrial DNA Mutation and Depletion Increase the Susceptibility of Human Cells to Apoptosis....Pages 133-145
Resistance of ρ 0 Cells against Apoptosis....Pages 146-153
Mitochondrial DNA 4,977-bp Deletion in Paired Oral Cancer and Precancerous Lesions Revealed by Laser Microdissection and Real-Time Quantitative PCR....Pages 154-167
Role of Oxidative Stress in Pancreatic β-Cell Dysfunction....Pages 168-176
Initiation of Apoptotic Signal by the Peroxidation of Cardiolipin of Mitochondria....Pages 177-184
Diabetes Mellitus with Mitochondrial Gene Mutations in Japan....Pages 185-192
Accumulation of Somatic Mutation in Mitochondrial DNA and Atherosclerosis in Diabetic Patients....Pages 193-204
Changes of Mitochondrial DNA Content in the Male Offspring of Protein-Malnourished Rats....Pages 205-216
Mitochondrial Encephalomyopathies....Pages 217-231
Mitochondrial Encephalomyopathies....Pages 232-245
Comprehensive Molecular Diagnosis of Mitochondrial Disorders....Pages 246-258
Molecular Pathogenetic Mechanism of Maternally Inherited Deafness....Pages 259-271
Genetic and Functional Analysis of Mitochondrial DNA-Encoded Complex I Genes....Pages 272-283
Genome-Wide Analysis of Signal Transducers and Regulators of Mitochondrial Dysfunction in Saccharomyces cerevisiae ....Pages 284-298
Enhanced Detection of Deleterious Mutations by TTGE Analysis of Mother and Child’s DNA Side by Side....Pages 299-303
Quantitative PCR Analysis of Mitochondrial DNA Content in Patients with Mitochondrial Disease....Pages 304-309
Somatic Mitochondrial DNA Mutations in Oral Cancer of Betel Quid Chewers....Pages 310-316
Association of the Mitochondrial DNA 16189 T to C Variant with Lacunar Cerebral Infarction....Pages 317-324
Mechanisms of Cell Death Induced by Cadmium and Arsenic....Pages 325-331
Cadmium-Induced Nephropathy in Rats Is Mediated by Expression of Senescence-Associated Beta-Galactosidase and Accumulation of Mitochondrial DNA Deletion....Pages 332-338
Investigation of Common Mitochondrial Point Mutations in Korea....Pages 339-344
Leber’s Hereditary Optic Neuropathy: The Spectrum of Mitochondrial DNA Mutations in Iranian Patients....Pages 345-349
Back Matter....Pages 351-352