Mitochondrial Disorders: From Pathophysiology to Acquired Defects

Front Matter....Pages N1-III
Introduction....Pages 1-2
Front Matter....Pages 3-3
The Mitochondrial Machinery....Pages 5-15
Mitochondria in neurodegeneration....Pages 17-35
Apoptosis and Oxidative Stress in Mitochondrial Disorders....Pages 37-45
Mitochondria and Ageing....Pages 47-58
Cardiac Mitochondrial Dysfunction in Aging and in Ischemia/Reperfusion Role of Oxygen Free radicals and Cardiolipin....Pages 59-69
Deregulation of Mitochondrial Apoptosis in Cancer....Pages 71-87
Front Matter....Pages 89-89
Drug induced Hepatotoxicity and Mitochondrial Dysfunction....Pages 91-105
The Carnitine System Involvement in Mitochondrial Pharmacologic Sensitivity....Pages 107-130
Mitochondrial Toxicity of Anti-Retroviral Drugs....Pages 131-140
Mitochondrial Damage in HIV Patients treated with Highly Active Antiretroviral Therapy....Pages 141-152
Hyperlactatemia and HIV-infected Patients with Nucleoside Analog Reverse-transcriptase Inhibitors Treatment: the Clermont HIV Cohort Study....Pages 153-160
Severe Lactic Acidosis and Multiple Organ Failure in HIV Patients treated with Nucleoside Analogues reverse Transcriptase Inhibitors: a Pilot Study of Treatment with L-Carnitine....Pages 161-172
Mitochondrial Dysfunction in Perinatal Exposure to Antiretroviral Nucleoside Analogues....Pages 173-181
Front Matter....Pages 183-189
Neurological Features of Genetic and Acquired Metabolic Mitochondrial Defects....Pages 191-191
Clinical Heterogeneity associated to Dysfunction of Mitochondrial DNA: the Example of the 3243 “MELAS” Mutation....Pages 193-210
Inborn and Acquired Mitochondrial Leucodystrophy....Pages 211-219
Mitochondrial Dysfunction, Epilepsy, and Antiepileptic Drugs....Pages 221-229
Friedreich Ataxia as an Example of the Dual Genome Control of Mitochondrial Function....Pages 231-245
Front Matter....Pages 247-253
How Wide are Mitochondria Involved in Exercise Intolerance ?....Pages 191-191
Mitochondrial Defects in Myositis and Inclusion Body Myopathies....Pages 255-263
Mitochondrial Dysfunction and the Gastrointestinal System....Pages 265-274
Mitochondrial Diabetes: Clinical Specificity and Diagnosis....Pages 275-285
Front Matter....Pages 287-294
Treatment of Mitochondrial Diseases....Pages 295-303
....Pages 305-305