Mitochondria in Pathogenesis

Front Matter....Pages 1-1
Flow Cytometric Analysis of Mitochondrial Function....Pages 3-20
Confocal Microscopy of Mitochondrial Function in Living Cells....Pages 21-49
Front Matter....Pages 51-51
Primary Disorders of Mitochondrial DNA and the Pathophysiology of mtDNA-Related Disorders....Pages 53-80
Transmission and Segregation of Mammalian Mitochondrial DNA....Pages 81-93
Cardiac Reperfusion Injury: Aging, Lipid Peroxidation, and Mitochondrial Function....Pages 95-111
Front Matter....Pages 113-113
Ca 2+ -Induced Transition in Mitochondria: A Cellular Catastrophe?....Pages 115-124
Physiology of the Permeability Transition Pore....Pages 125-152
Control of Mitochondrial Metabolism by Calcium-Dependent Hormones....Pages 153-175
The Permeability Transition Pore in Myocardial Ischemia and Reperfusion....Pages 177-199
Mitochondrial Calcium Dysregulation during Hypoxic Injury to Cardiac Myocytes....Pages 201-213
Mitochondrial Implication in Cell Death....Pages 215-246
Role of Mitochondria in Apoptosis Induced by Tumor Necrosis Factor-α....Pages 247-263
The ATP Switch in Apoptosis....Pages 265-277
Front Matter....Pages 279-279
Reactive Oxygen Generation by Mitochondria....Pages 281-300
Role of the Permeability Transition in Glutamate-Mediated Neuronal Injury....Pages 301-316
Mitochondrial Dysfunction in the Pathogenesis of Acute Neural Cell Death....Pages 317-331
Varied Responses of Central Nervous System Mitochondria to Calcium....Pages 333-340
Mitochondrial Dysfunction in Oxidative Stress, Excitotoxicity, and Apoptosis....Pages 341-359
Mitochondria in Alcoholic Liver Disease....Pages 361-377
Mitochondrial Changes after Acute Alcohol Ingestion....Pages 379-391
Front Matter....Pages 279-279
Mitochondrial Dysfunction in Chronic Fatigue Syndrome....Pages 393-410
Front Matter....Pages 411-411
Bile Acid Toxicity....Pages 413-423
Reye’s Syndrome and Related Chemical Toxicity....Pages 425-450
Purinergic Receptor-Mediated Cytotoxicity....Pages 451-466
Doxorubicin-Induced Mitochondrial Cardiomyopathy....Pages 467-488
Drug-Induced Microvesicular Steatosis and Steatohepatitis....Pages 489-517