Microenvironments in the Lymphoid System

Front Matter....Pages i-xxiv
Front Matter....Pages 1-1
Prospects for Understanding the Role of Lymphoid Microenvironments in B Cell Differentiation In Vivo ....Pages 3-8
Pre-B Cells in Rat Bone Marrow: Identification, Surface Markers and Isolation....Pages 9-16
T Cell Markers on Pre-B Cells in the Rat....Pages 17-26
Ig Light Chain Gene Rearrangement and Chromosomal Abnormality in the Lama Early B-Lineage Tumour of the Rat....Pages 27-33
In Vivo Regulation of B Lymphocyte Production in the Bone Marrow: Effects and Mechanism of Action of Exogenous Stimuli on Pre-B Cell Proliferation and Lymphocyte Turnover....Pages 35-46
Influence of the XID Mutation on B Lymphocyte Development in Adult Mice....Pages 47-55
In Vitro Growth and Differentiation of Rat B Cell Subpopulations....Pages 57-64
B Cell Production in Adult Rats....Pages 65-71
The Paradox of High Rates of B Cell Production in Bone Marrow and the Longevity of Most Mature B Cells....Pages 73-80
Monoclonal Antibodies to Rat B Lymphocyte (Sub-)Populations....Pages 81-89
Effect of Early Embryonic Bursectomy on Lymphocyte Differentiation and Maturation....Pages 91-99
Evidence for the Existence of Two Distinct Types of Peyer’s Patches in Sheep....Pages 101-109
Evidence of Differences Between Peyer’s Patches and Germinal Centers....Pages 111-118
Differentiation of B Lymphocytes in Sheep. II. Surface Phenotype of B Cells Leaving the ‘Bursa-Equivalent’ Lymphoid Tissue of Sheep, Ileal Peyer’s Patches....Pages 119-126
Origin and Fate Of IgE-Bearing Lymphocytes: Modulation of IgE Isotype Expression on Peyer’s Patch Cells....Pages 127-130
Immunoglobulin Isotypes and Antibody Specificity Repertoire of “Spontaneously” Occurring (“Background”) Immunoglobulin-Secreting Cells in Germfree Mice Fed Chemically Defined Ultrafiltered “Antigen-Free” Diet....Pages 131-138
Comparative Analysis of the Development of B Cells in Marginal Zones and Follicles....Pages 139-144
Germinal Center Cells: Antigen Specificity, Heavy Chain Class Expression and Evidence of Memory....Pages 145-151
The Development of Specific Antibody Producing Cells in the Spleen of Rabbits During the Primary and Secondary Immune Response....Pages 153-159
The Ontogenetic Development of the Follicular Dendritic Cell in Rat Spleen....Pages 161-166
Front Matter....Pages 1-1
Origin and Turnover of Follicular Dendritic Cells and Marginal Zone Macrophages in the Mouse Spleen....Pages 167-170
Mouse Lymph Node Follicular Dendritic Cells: Quantitative Analysis and Isolation....Pages 171-183
Antigen/Antibody Retention by Follicular Dendritic Cells (FDC)....Pages 185-191
Antigenic Phenotype of Rodent Follicular Dendritic Cells in Vitro and in Situ ....Pages 193-202
B Cell Differentiation: B Cell Subsets and Factors, Organs or Structures Involved in B Lymphocyte Genesis....Pages 203-211
Front Matter....Pages 213-213
Precursors of T-Cell Mitogen Reactive Cells and their Suppressors in the Mouse Fetal Liver....Pages 215-221
Thymus Homing Clonogenic Bone Marrow Cells....Pages 223-227
The Role of the Thymic Cortex and Medulla in T Cell Differentiation....Pages 229-234
Intrathymic Differentiation in the Rat....Pages 235-244
Stromal Cell Populations in the Developing Thymus of Normal and Nude Mice....Pages 245-249
New Surface Antigens on Cells in the Early Phase of T-Cell Differentiation, Detected by Monoclonal Antibodies....Pages 251-260
Studies on the Role of the Thymus in the Selection and Clonal Expansion of T-Cell Precursors....Pages 261-271
Culture of Mouse Thymic Epithelial Cells and Studies of Age-Related Changes....Pages 273-282
Heterogeneity of Human Thymus Epithelial Cells Revealed by Monoclonal Anti-Epithelial Cell Antibodies....Pages 283-288
Heterogeneity of the Human Thymus Epithelial Microenvironment at the Ultrastructural Level....Pages 289-297
T Cell Differentiation Within TNC Related Lympho-Epithelial Complexes in the Thymus Cortex....Pages 299-305
The Relation Between Thymic Interdigitating Cells and Dendritic Cells....Pages 307-312
“T-Cells” in Nude Rats....Pages 313-321
T-Cells and T-Cell Subsets in Rat Bronchus Associated Lymphoid Tissue (BALT) in Situ and in Suspension....Pages 323-329
K Cell Activity is Independent of Both Thymus and Spleen....Pages 331-339
Front Matter....Pages 213-213
Use of Transgenic Mice with Human MHC Class 1 Gene (HLA-A2)....Pages 341-347
Effect of Sympathectomy on the Maturation of Fetal Thymocytes Grown within the Anterior Eye Chambers in Mice....Pages 349-356
The Effect of Dioctyltin Dichloride on the Thymus and T-Cell Differentiation in the Rat....Pages 357-365
Front Matter....Pages 367-367
Antibody Responses to T-Dependent Antigens: Contributions of Dendritic Cells and Helper T Lymphocytes....Pages 369-376
Development of Dendritic Cells from Rat Bone Marrow....Pages 377-381
The Relation Between Rat Lymph Node Interdigitating Cells in Situ and Dendritic Cells in Suspension....Pages 383-388
Dendritic Cells and Macrophages as Antigen Presenting Cells in Ovalbumin-Induced T Lymphocyte Proliferation in vitro....Pages 389-394
Veiled Cell Lymphocyte Interaction....Pages 395-399
A Comparison Between Antigen-Laden Cells and Dendritic Cells in Afferent and Efferent Lymph....Pages 401-408
The Heterogeneity of Mononuclear Phagocytes in Lymphoid Organs: Distinct Macrophage Subpopulations in Rat Recognized by Monoclonal Antibodies ED1, ED2 and ED3....Pages 409-419
Macrophages Migrate from the Marginal Zone into the Germinal Centre of the Rodent Spleen....Pages 421-426
Splenic Dependence of the Antibody Response to the TI-2 Antigen, DNP-Ficoll: Effect of the Ficoll Carrier on the Tissue Distribution of 125-I-Ficoll Conjugates....Pages 427-435
Evidence that Static but Not Recirculating B Cells are Responsible for Antibody Production Against Dinitrophenol on Neutral Polysaccharide, A TI-2 Antigen....Pages 437-442
T-Lymphocytes in Rat Lymphoid Follicles are a Subset of T Helper Cells....Pages 443-449
Functional Differences Associated with Quantitative Distribution of Ia Antigens on Mouse B Cells....Pages 451-455
Evidence for a Clonal Development of Specific Antibody Forming Cells in the Spleen....Pages 457-462
Modification of Immune Induction by Adjuvant....Pages 463-469
Footpad Responses in Nude Mice Immunized with Chicken Erythrocytes....Pages 471-476
Cellular Characteristics of the Rosette Forming Cells in the Mouse Spleen....Pages 477-486
The Bursa of Fabricius as a Trapping Mechanism for Environmental Antigens....Pages 487-493
Front Matter....Pages 367-367
Maternal Autoimmune Disease Influences Self-Tolerance in Offspring....Pages 495-502
The Role of Suppresor T Lymphocytes in the Maintenance of Tolerance to Alloantigens in Bone Marrow Chimeras Prepared with Total Lymphoid Irradiation (TLI)....Pages 503-509
The Role of Memory Suppressor T Cells in Self Tolerance: Induction in Utero and in Athymic Mice....Pages 511-520
The Long-Lasting State of Specific Nonresponsiveness Induced By Intravenous Immunization with Alloantigens is Due to the Generation of Recirculating Suppressor T Cells....Pages 521-529
Pathogenesis of the Intestinal Phase of the Graft-Versus-Host Reaction inn F 1 Hybrid Mice....Pages 531-538
Graft Versus Host Reaction in the Rat: Effect of Cyclosporin A and Cyclophosphamide on Lymphocyte Subsets Involved in GvHR....Pages 539-544
Graft Versus Host Disease in the Rat: Ia Expression on Target Tissues....Pages 545-554
Induction of Class I and Class II Antigens During Rejection of Allografted Human Hearts....Pages 555-563
Enhanced Regeneration of Transplanted Splenic Tissue by Increased Work Load....Pages 565-569
Retinoid Effects on Murine Immune Responses....Pages 571-577
Effect of Avridine on Enteric Antigen Uptake and Mucosal Immunity to Reovirus (1/Lang)....Pages 579-590
Front Matter....Pages 591-591
Regulation of the Size of the Recirculating B Cell Pool of Adult Rats....Pages 593-601
The Influence of Complement Receptors on the Localization of Lymphocytes in Vivo....Pages 603-608
Interaction of High Endothelial Venules with T and B Cells after Antigenic Stimulation....Pages 609-614
Human Lymphocyte-High Endothelial Venule Interaction: Functional and Molecular Characterization....Pages 615-620
T Cell Clones: A Model of a Non-Recirculating Phase of T Cell Differentiation....Pages 621-627
Radiosensitivity of the Circulation of DTH Effector T Lymphocytes : An Accurate Estimate Using a Quantitative Assay....Pages 629-636
Evidence for Local Neuromodulation of T Cell Migration in Vivo....Pages 637-645
Lymphocyte Migration from Peyer’s Patches by Diapedesis through M Cells into the Intestinal Lumen....Pages 647-654
Emigration of Newly Formed Lymphocytes From Ileal Peyer’s Patches in Lambs....Pages 655-660
Front Matter....Pages 591-591
Patterns of Migration of Labelled Blood Lymphocyte Subpopulations: Evidence for Two Types of Peyer’s Patch in the Young Pig....Pages 661-668
Interaction Mechanism of Clustering Lymphocytes: Specificity Molecular Properties and its Relation to Migration....Pages 669-674
Exploiting Lymphocyte Traffic to Deliver Radioactivity or Ricin to Lymphatic Tissues....Pages 675-680
Front Matter....Pages 681-681
TMF, A Thymic Epithelial Glycoprotein: Chemotaxis of Hematopoietic Precursor Cells....Pages 683-691
Characterization of T Cell Growth Factor Responsive Thymocytes in Guinea Pigs....Pages 693-700
Lymphokine Production by T Lymphocytes Isolated from Murine Small Intestinal Epithelium....Pages 701-711
Resistance to the Induction of T Cell-Mediated Autoimmunity Correlates with Lower IL 2 Production....Pages 713-720
Detection of Antibody-Induced Feedback Suppression in Spleen Cell Populations of Primed and Unprimed Mice....Pages 721-727
IgD-Induced Enhancement of the Immune Response....Pages 729-738
Regulation of Isotype Expression in the Immune Response to Type-2 Thymus Independent Dextran Antigens....Pages 739-747
Organ-Selective Impairment of Phagocytosis by Cadmium....Pages 749-755
Quantitation of Murine IgE in an Automatic Elisa System....Pages 757-765
Double Immunoenzymatic Staining Employing Rat and Mouse Monoclonal Antibodies....Pages 767-775
Front Matter....Pages 777-777
Monoclonal Antibodies as Therapeutic Tools In Vivo....Pages 779-787
Immunosuppression with Monoclonal Antibodies — Rules for Effective Serotherapy....Pages 789-795
Interaction of Rat Monoclonal Antibodies with Human Killer Cells....Pages 797-803
Therapeutic Potential of Monoclonal Antibodies to the Leucocyte Common Antigen....Pages 805-812
Elimination of Graft Versus Host Disease in Matched Allogeneic Leukemic Transplant Recipients Using Campath-1....Pages 813-818
The Immunotherapeutic Effect of Anti Lyt-1 Antibodies on Local and Metastatic Tumor Growth....Pages 819-826
Chemotactic Anti-Tumour Antibodies: In Vitro Results with Four Different Antibody Preparations....Pages 827-832
Front Matter....Pages 777-777
A Monoclonal Antibody with Selectivity for Human Kappa Myeloma and Lymphoma Cells which has Potential as a Therapeutic Agent....Pages 833-841
Derivatives of Anti-Idiotype Antibodies in the Treatment of B-Cell Lymphoma....Pages 843-853
Protective Effects of Monoclonal Antibodies and Immunopurified Glycoproteins in Primary HSV-1 Infection....Pages 855-861
A New Indicator of Human Malignant Tumour Found on Erythrocytes....Pages 863-868
Rat Monoclonal Antibodies for Bone Marrow Transplantation — The Campath Series....Pages 869-875
Front Matter....Pages 877-877
Changes of Lymphoid Microenvironments in Human Diseases — A Short Review....Pages 879-887
The Small Subpopulation of T Cell Marker + /Tdt + Cells in the Human Bone Marrow may Represent Prothymocytes....Pages 889-899
M + Lymphocytes of the Human Foetal Liver are Precursors of T Lymphocytes....Pages 901-908
M Receptor and T-Cell Differentiation in the Human Foetal Liver: An in Vitro Study....Pages 909-913
Is Ia Antigen Expression by Thymic Epithelial Cells Constitutive?....Pages 915-919
The Thymus in “Bare Lymphocyte” Syndrome....Pages 921-928
The Thymus in Myasthenia Gravis: An Immunohistologic Study....Pages 929-936
B Cell Function in Acute Malaria....Pages 937-947
The Origin of B-Chronic Lymphocytic Leukaemia (B-CLL) and its Relationship to Hairy Cell Leukaemia (HCL)....Pages 949-956
Increased Representation of a Subpopulation of Early B Cells in the Peripheral Blood of Patients with Rheumatoid Arthritis....Pages 957-961
Nodular Lymphocyte Predominance Type of Hodgkin’s Disease is a B Cell Lymphoma....Pages 963-969
Two Monoclonal Antibodies Raised Against a Burkitt Lymphoma Cell Line Recognise Separate Components of Lymphoid Follicles....Pages 971-978
Isolation of Germinal Centre (Gc) Cells is Greatly Improved by using the Protease Dispase to Prepare Cell Suspensions....Pages 979-984
Follicular Dendritic Cells Isolated from Human Tonsils....Pages 985-991
Follicular Dendritic Cells in Human Germinal Centres and Lymphomatous Follicles; A Morphological Comparison....Pages 993-998
Front Matter....Pages 877-877
The Nature of the Folliculoid Structures in Eosinophilic Lymphfolliculoid Granuloma (Kimura’s Disease)....Pages 999-1008
Norman and Neoplastic Langerhans Cells: Phenotypic Comparison with Other Types of Macrophages....Pages 1009-1015
Ia + T10 + Blast Cells in Acute Lymphoblastic Leukaemia are Precursors of T + and B + Cells....Pages 1017-1025
A Study of Lymph Node Lymphocytes in Rheumatoid Arthritis....Pages 1027-1032
Benign and Malignant Lymphocytic Skin Infiltrates Immunological Patterns Recognized by Immunohistochemical Staining with Monoclonal Antibodies....Pages 1033-1041
Differential Expression of Class II MHC Antigens on Cells Derived from Human Tissue....Pages 1043-1050
Beta-Adrenergic Regulation of the Blood Lymphocyte Phenotype Distribution in Normal Subjects and Splenectomized Patients....Pages 1051-1062
Characterisation of Mononuclear Cell Infiltrates by Monoclonal Antibodies in Normal and Neoplastic Colorectal Tissue....Pages 1063-1068
Human Lymphocyte Subpopulation in Lymphadenopathies in Homosexual Men....Pages 1069-1076
Back Matter....Pages 1077-1079