Microbial Reagents in Organic Synthesis

Front Matter....Pages i-x
Front Matter....Pages 1-1
Cyclase Mediated Synthesis of Terpenoids....Pages 3-24
(R)- and (S)-Cyanohydrins - Their Enzymatic Synthesis and Their Reactions....Pages 25-33
Chemical-Enzymatic Synthesis of Carbohydrates....Pages 35-42
A Building Block Strategy for Asymmetric Synthesis: The DHAP-Aldolases....Pages 43-55
Transferase Catalyzed Synthesis: Applications in Series of Aminoacids and Monosaccharides....Pages 57-66
Acyloin Formation Mediated by Benzoylformate Decarboxylases....Pages 67-75
Front Matter....Pages 77-77
Organic Synthesis Via Biocatalytic Methods — A Chemoenzymatic Approach to the Synthesis of FK506....Pages 79-92
Use of Enzymes as Catalysts in Key Reactions Leading to the Synthesis of Optically Active Natural Products and Analogues....Pages 93-111
New Enzymatic Methods for the Selective Functionalization of Carbohydrate Derivatives....Pages 113-122
Efficient Synthesis of Optically Active Carbohydrates and Other Oxygenated Compounds Through Bio-Oxidation of Chlorinated Aromatics....Pages 123-134
Chemoenzymatic Synthesis of Natural Products and Bioactive Compounds....Pages 135-147
Biotransformations Applied to the Synthesis of Vitamins and Pharmaceuticals....Pages 149-158
Front Matter....Pages 159-159
A Direct Route from Hydantoins to D-Amino Acids Employing a Resting Cell Biocatalyst With D-Hydantoinase and D-Carbamoylase Activity....Pages 161-174
The Use of Immobilized Penicillin G Acylase in Organic Synthesis....Pages 175-188
Are Proteases Suitable Tools for the Formation of Peptide Bonds?....Pages 189-198
Enzymatic Aminolysis, Hydrazinolysis and Oximolysis Reactions....Pages 199-208
Microbial and Enzymatic Transformation of Nitriles....Pages 209-223
Resolution of Racemates with Lipases and Effect of Reaction Conditions on Enantioselectivity....Pages 225-238
Selectivity Enhancement Of Candida Cylindracea Lipase: Covalent Enzyme Modification and Control of Micro-pH....Pages 239-247
Lipase Catalyzed Organic Synthesis....Pages 249-260
Front Matter....Pages 159-159
Kinetics and Validation of Mathematical Models of Enantioselective Transesterification in Organic Solvents....Pages 261-272
Enzymatic enantioselective ester hydrolysis by carboxylesterase NP....Pages 273-288
A Kinetic Interpretation of Acids and Alcohols Influence on the Enantioselectivity in Enzyme Catalysed Resolutions....Pages 289-298
Asymmetrized Tris (Hydroxymethyl)Methane and Related Synthons as New Highly Versatile Chiral Building Blocks. Chemoenzymatic Preparation and Synthetic Applications....Pages 299-310
Front Matter....Pages 311-311
A Comparative Study of Chemical versus Biological Functionalizations of Synthetic Intermediates....Pages 313-321
Enantioselective Sulfoxidations Catalyzed by Chloroperoxidase and Horseradish Peroxidase....Pages 323-331
Use of Biooxygenation in Fine Organic Synthesis....Pages 333-346
The Enzymatic Baeyer-Villiger Oxidation....Pages 347-360
Beauveria Sulfurescens Mediated Oxidation of Dihydroartemisinin Derivatives....Pages 361-373
Front Matter....Pages 375-375
Comparison of Chemical and Biochemical Reduction Methods for the Synthesis of (R)-2-Hydroxy-4-Phenylbutyric Acid....Pages 377-388
Stereochemical Control in Microbial Reduction....Pages 389-398
Approaches to 2-Methyl-1-Alkanols of High Enantiomeric Purities Via Enzyme Mediated Reactions....Pages 399-410
Microbial Alcohol/Aldehyde Oxidoreductases in Enantioselective Conversions....Pages 411-420
Stereocontrolled Reduction of β-Ketoesters with Geotrichum Candidum ....Pages 421-440
Usefull Enzymes from Plant Cell and Organ Cultures....Pages 441-453
Back Matter....Pages 455-490