Micro Total Analysis Systems ’98: Proceedings of the uTAS ’98 Workshop, held in Banff, Canada, 13–16 October 1998

Front Matter....Pages i-xvi
Front Matter....Pages 1-1
Cell Sorting in Microfluidic Systems....Pages 39-44
Electrohydrodynamic Pumps for High-Density Microfluidic Arrays....Pages 45-48
Electrokinetic Generation of High Pressures using Porous Microstructures....Pages 49-52
Studies of Hydrostatic Pressure Effects in Electrokinetically Driven μTAS....Pages 53-56
An Electronic Nose Based on A Micromechanical Cantilever Array....Pages 57-60
Chemical Analysis Based on Environmentally Sensitive Hydrogels and Optical Diffraction....Pages 61-64
Mass-Sensing Multianalyte Micro-Array Based Immunoassay by Direct Nir Fluorescence and Quantitative Image Analysis....Pages 65-68
Biology Lab-on-a Chip for Drug Screening....Pages 69-72
Results Obtained using A Prototype Microfluidics-Based Hematology Analyzer....Pages 73-76
Rare Event Cell Surging in a Microfluidic System for Application in Prenatal Diagnosis....Pages 77-80
Simultaneous Self-Referencing Analyte Determination in Complex Sample Solutions Using Microfabricated Flow Structures (T-Sensors™)....Pages 81-84
Fabrication of Injection and Switching Valve for Whole Blood Control....Pages 85-88
DNA Analysis with Capillary Array Electrophoresis Microplates....Pages 1-6
Continuous Flow PCR on A Chip....Pages 7-10
Advances in Integrated Genetic Analysis....Pages 11-16
Photo-Polymer Microchannel Technologies and Applications....Pages 17-22
Parallel Separations in Microfabricated Channels With Capillary Electrophoretic Sample Introduction....Pages 23-26
Novel Interconnection and Channel Technologies for Microfluidics....Pages 27-30
A μTAS Based on Microdialysis for On-Line Monitoring of Clinically Relevant Substances....Pages 31-34
Microdevices for Electrospray Mass Spectrometry....Pages 35-38
Front Matter....Pages 1-1
A Microfluidics-Based Microcytometer: Interfacing Microfluidics with Macrofluidics....Pages 89-92
Microfabricated Biosensors for Measuring Neurotransmitters from Cultured Nerve Cells....Pages 93-96
Anti-Resonant Reflecting Optical Waveguides (ARROWS) as Optimal Optical Detectors for μTAS Applications....Pages 97-100
Probe Beam Deflection of Isotachophoresis on Miniaturized Planar Glass Devices....Pages 101-104
Integration of Microelectrodes with Etched Microchannels for In-Stream Electrochemical Analysis....Pages 105-108
On-Line Detection of Electrophoretic Separations on A Microchip by Raman Spectroscopy....Pages 109-112
Electrophoretic Separations in Ultrathin Channels Using Microelectrode Array Detection....Pages 113-116
Micromechanical Thermogravimetry on Single Zeolite Crystals....Pages 117-120
A One-Spot Electrochemical Transducer for Use in μTAS....Pages 121-124
Various Current Regimes Applicable for Sensing in μTAS....Pages 125-128
Optimisation of Porous Silicon Carrier Matrices Applied in Chip Based Micro Enzyme Reactors....Pages 129-132
Electrochemical Fabrication of Multi Walled Micro Channels....Pages 133-136
Utilizing the {111} Plane Switch-Over Etching Process for Micro Fluid Control Applications....Pages 137-140
Coupling Electrospray Mass Spectrometry to Microfluidic Devices With Low Dead Volume Connections....Pages 141-144
Silicon-Micromachined Separation Columns Coated with Amino Acid Films for an Integrated On-Chip Gas Chromatograph....Pages 145-148
Computer Simulations for Microchip Electrophoresis....Pages 149-152
Electrophoretic Separation of Antisense DNA using Polymer-Solution Filled Capillary by Cross-Injection....Pages 153-156
Integrated Serial Dilution on a Microchip for Immunoassay Sample Treatment and Flow Injection Analysis....Pages 157-160
Minimizing Dispersion Introduced by Turns on Microchips....Pages 161-164
Use of Surfactant Additives for Modification of Electroosmotic Flow and Wall Chemistry....Pages 165-168
Front Matter....Pages 1-1
Sample Matrix Effects on Injection and Sample Loading in Integrated Capillary Electrophoresis Devices....Pages 169-172
Development of a Microfabricated Biochemical Workbench — Improving the Mixing Efficiency —....Pages 173-176
Micro Mixer Incorporated with Piezoelectrially Driven Valveless Micropump....Pages 177-180
Liquid Mixing Studies with an Integrated Mixer/Valve....Pages 181-184
Fabrication of an Integrated Mixing/Reaction Micro Flow Cell for μTAS....Pages 185-188
Micro-Fluidic Diffusion Coefficient Measurement....Pages 189-192
Front Matter....Pages 193-193
Sizing, Fractionation and Mixing of Biological Objects Via Microfabricated Devices....Pages 193-198
Individual Embryo Transport and Retention on a Chip....Pages 199-202
Single Cell Enzymatic Analysis on a Microchip: Lysing of Single Cells and Identification of Their β-Galactosidase Activity....Pages 203-206
Applying Microfluidic Chemical Analytical Systems to Imperfect Samples....Pages 207-212
Building Highly Diverse Arrayed Substance Libraries by Micro Offset Printing....Pages 213-216
Fluorescence Array Biosensor Part 2: Biochemistry and Application....Pages 217-220
An Integrated Microelectronic Hybridization System for Genomic Research and Diagnostic Applications....Pages 221-224
Development of A Generic Microfluidic System for Electrochemical Immunoassay-Based Remote Bio/Chemical Sensors....Pages 225-230
Integrated Microsystem for Sample Introduction, Mixing, Reaction, Separation and Self Calibration of Immunoassays....Pages 231-234
Continuous Flow Versus Batch Process—A few Examples....Pages 235-240
Micro-TAS on Polymer Substrates Micromachined by Laser Photoablation....Pages 241-244
Key Elements of A Transparent Teflon® Microfluidic System....Pages 245-248
An Inexpensive Plastic Technology for Microfabricated Capillary Electrophoresis Chips....Pages 249-252
Microfluidic Manifolds by Polymer Hot Embossing for μ-Tas Applications....Pages 253-256
Front Matter....Pages 193-193
Multiplexed, Disposable, Plastic Microfluidic Systems for High-Throughput Applications....Pages 257-260
Front Matter....Pages 261-261
Impedances for Design of Microfluidic Systems....Pages 299-302
Miniaturized Electrocaloric Flow Controller for Analyte Multiplexing and Cell/Particle Sorting....Pages 303-306
Hydrophobic Microcapillary Vent for Pneumatic Manipulaiton of Liquid in μtas....Pages 307-310
Microfabricated Chips for Capillary Electrophoresis on Quartz Glass Substrates Using a Bonding with Hydrofluoric Acid....Pages 311-314
Microoptical Fluorescence Detection for Chip-Based Multiplexed Analysis Systems....Pages 281-285
Micro-Optical Systems for Fluorescence Detection in μtas Applications....Pages 287-290
Integrated Bio/Chemical Microsystems Employing Optical Detection: A Cytometer....Pages 291-294
Photothermal Ultrasensitive Detection and Microchemistry in the Integrated Chemistry Lab....Pages 295-298
Rapid Electrophoretic and Chromatographic Analysis on Microchips....Pages 315-318
Free Flow Electrophoresis Module Fabricated with Pyrex Glass....Pages 319-322
A Miniaturized Planar Isotachophoresis Separation Device for Transition Metals with Integrated Conductivity Detection....Pages 323-326
Characterization of Silicon-Based Insulated Channels for Capillary Electrophoresis....Pages 327-330
Novel Microfabricated Capillary Array Electrophoresis Chip Fabricated by Synchrotron Radiation and Direct Observation of Dynamics of DNA Molecules Migrating in Microchannels....Pages 331-334
Micro-Genetic Analysis Systems....Pages 261-266
A Microfabricated Fluidic Reaction and Separation System for Integrated DNA Analysis....Pages 267-270
High-Performance DNA Separations in Microchip Electrophoresis Systems....Pages 271-275
Nucleic Acid Concentration and PCR for Diagnostic Applications....Pages 277-280
Continuous Flow Versus Stopped flow in A Micro flow Injection System....Pages 335-338
Microfabricated Channels and Fluid Control Systems for Integrated Flow Injection Analysis....Pages 339-342
Front Matter....Pages 261-261
Microfabricated Dual-Microdialysis and Capillary Isoelectric Focusing Devices for Cleanup and Separations / Mass Spectrometric Analysis of Biomolecules....Pages 343-346
Chip-Based Heterogeneous Immunoassay for Clinical Diagnostic Applications....Pages 347-350
Micro-Analytical (μFIA) Reactor for the Determination of Phosphate as Orthophosphate....Pages 351-354
Investigation of Chemiluminescent Microanalytical Systems....Pages 355-358
Isotachophoresis on Planar Polymeric Substrates....Pages 359-362
Application of Thin Cross-Linked Gelatin Layers in Micro Systems Technology....Pages 363-366
Plastic Microfluid Devices for Clinical Measurements....Pages 367-370
Fabrication Processes for Polymer-Based Microfluidic Analytical Devices....Pages 371-374
μ-Structured Polymers as Components of Chemical Microreactors....Pages 375-378
Development of Microfabricated Valves for μTAS....Pages 379-381
A Silicon Micropump with a High Bubble Tolerance and Self-Priming Capability....Pages 383-386
Flow-Through Microdispensing; Design and Applications....Pages 387-390
Manufacturing of Self-Priming Plastic Micropumps....Pages 391-394
Micromachined Bi-Directional Liquid Pump with Thermally Controlled Dynamic Valves....Pages 395-398
Micro Ball Valve for Fluidic Micropumps and Gases....Pages 399-402
Nanomanipulation Techniques Inside the SEM -First Attempts to Integrate Microfabrication into a SEM....Pages 403-406
Fluidics for a Multi-Analyte Detector Based on Intermolecular Binding Forces....Pages 407-410
Reagent Handling by Manipulation of Magnetic Particles: A New Approach to the Automation and Miniaturisation of Analytical Chemistry....Pages 411-414
Novel DNA Manipulation Based on Local Temperature Control: Transportation and Scission....Pages 415-418
Numerical Simulation of Magnetic Separation of Particles in a Rectangular Microchannel....Pages 419-422
Front Matter....Pages 261-261
Automated Microchip Platform for Biochemical Analysis....Pages 423-426
Automatic Sensor System for Water Analysis....Pages 427-430
Fluoriscence Array Biosensor Part 1: Optics and Fluidics....Pages 431-434
Microseparations and Microfluidic Studies....Pages 435-438
μTAS for Volumetric or Coulometric Titrations of Nanomole Amounts of Analytes in Microliter Samples....Pages 439-442
System Requirements for a Portable Cell Based Sensor....Pages 443-446
Laboratory on Chip for Clinical Applications....Pages 447-450
Front Matter....Pages 451-451
Microfabricated Liquid Chromatography Columns Based on Collocated Monolith Support Structures....Pages 451-455
Towards a Modular Microfluidic System for Proteome Analysis by Mass Spectrometry....Pages 457-462
Integrated Gas Phase Microreactors....Pages 463-468
 In Situ Detection of Cells and Biochemical Reactions by Optical Diffraction....Pages 469-472
Micromachined Flame Analyzers....Pages 473-476
Integrated Chemical Analysis Systems for Gas Phase CW Agent Detection....Pages 477-481
Back Matter....Pages 483-492