Methods of Assessing the Reinforcing Properties of Abused Drugs

Front Matter....Pages i-xiv
Intravenous Self-Administration: Response Rates, the Effects of Pharmacological Challenges, and Drug Preference....Pages 1-33
Screening for Drug Reinforcement Using Intravenous Self-Administration in the Rat....Pages 35-43
Assessing Drugs for Abuse Liability and Dependence Potential in Laboratory Primates....Pages 45-85
Interpretation of Lesion Effects on Stimulant Self-Administration....Pages 87-103
Second-Order Schedules of Drug Injection....Pages 105-115
Intravenous Drug Self-Administration: A Special Case of Positive Reinforcement....Pages 117-141
Oral Drug Self-Administration: Drugs as Reinforcers....Pages 143-160
Oral Self-Administration of Alcohol: A Valid Approach to the Study of Drug Self-Administration and Human Alcoholism....Pages 161-171
Intracranial Self-Administration Procedures for the Assessment of Drug Reinforcement....Pages 173-187
Prediction of Drug Abuse Liability from Animal Studies....Pages 189-198
Conditioned Reinforcement as a Measure of the Rewarding Properties of Drugs....Pages 199-210
Reinstatement of Drug-Taking Behavior as a Method of Assessing Incentive Motivational Properties of Drugs....Pages 211-227
Place Conditioning: A Simple and Effective Method for Assessing the Motivational Properties of Drugs....Pages 229-240
Conditioned Place Preference: A Parametric Analysis Using Systemic Heroin Injections....Pages 241-273
Anatomical and Neurochemical Substrates of Drug Reward Determined by the Conditioned Place Preference Technique....Pages 275-290
Applications and Limitations of the Drug Discrimination Method for the Study Of Drug Abuse....Pages 291-340
Drug Discrimination: Methods of Manipulation, Measurement, and Analysis....Pages 341-372
The Study of Structure-Activity Relationships Using Drug Discrimination Methodology....Pages 373-390
Tests Involving Pressing for Intracranial Stimulation as an Early Procedure for Screening Likelihood of Addiction of Opioids and Other Drugs....Pages 391-420
Brain Stimulation Rewards: Measurement and Mapping by Psychophysical Techniques and Quantitative 2-[ 14 C]Deoxyglucose Autoradiography....Pages 421-445
A Comparison of Two Methods Designed to Rapidly Estimate Thresholds of Rewarding Brain Stimulation....Pages 447-462
A Multifunctional On-Line Brain Stimulation System: Investigation of Alcohol and Aging Effects....Pages 463-478
Combined Microinjection and Brain Stimulation Reward Methodology for the Localization of Reinforcing Drug Effects....Pages 479-488
Addiction Research Center Inventory (ARCI): Measurement of Euphoria and Other Drug Effects....Pages 489-524
Operant Analysis of Human Drug Self-Administration: Marihuana, Alcohol, Heroin and Polydrug Use....Pages 525-558
A Drug Preference Procedure for use with Human Volunteers....Pages 559-572
Clinical Procedures for the Assessment of Abuse Potential....Pages 573-590
Operationalizing and Measuring the Organizing Influence of Drugs on Behavior....Pages 591-617
The Mouse as a Subject in the Study of Neural Mechanisms of Reward....Pages 619-633
An Overview of Assessing Drug Reinforcement....Pages 635-658