Metallic Biomaterial Interfaces

Metallic Biomaterial Interfaces......Page 4
Contents......Page 8
Preface......Page 14
List of Contributors......Page 16
I Interface Influence of Materials and Surface Modification......Page 24
1 Introduction......Page 26
References......Page 27
2.1 Preparation of Titanium and Titanium Alloys......Page 28
2.2 Development of Wear-Resistant Nanocrystalline and Dispersion Strengthened Titanium Materials for Implants......Page 30
2.3 Amorphous Titanium–Silicon Alloys: New Materials for Implants......Page 34
References......Page 41
3.1 Patterning by Mechanical Treatment......Page 42
3.2.1 Bioactive Nanostructures......Page 46
3.2.2 Micro Structured Titanium Surfaces Produced by Chemical and Electrochemical Etching......Page 51
3.2.3 Enhanced Hydrophobicity Achieved by Etching and Coating......Page 53
3.3.2 Laser Direct Writing......Page 60
3.3.3 Surface Microprocessing of Titanium Films by Self-limited Oxidation......Page 64
3.4 Plasma Processes......Page 67
References......Page 70
4.1.1 Sol–Gel Coatings......Page 74
4.1.2 Anodic and Thermal Oxide Coatings......Page 88
4.2 Biomimetic Apatite Formation......Page 94
4.3 Surface Modification by Covalent and Noncovalent Attachment of Biomolecules......Page 104
4.3.1 Immobilization of RGD Peptides......Page 106
4.3.2 Improving the Biocompatibility of Titanium- and Cobalt-Based Biomaterials by Covalent Immobilization of Crosslinked Collagen......Page 111
4.3.3 Modifying Titanium Surfaces with Glycosaminoglycanes for Hemocompatibility......Page 115
4.3.4 Surface Modification of Titanium for Improvement of the Interfacial Biocompatibility......Page 125
4.3.5 Biofunctionalization of Titanium Substrates Using Maleic Anhydride Copolymer Films......Page 129
References......Page 133
II Physical and Physicochemical Surface Characterization......Page 140
1 Introduction......Page 142
2.1 Mechanical Characterization......Page 144
2.2 Optical Characterization......Page 148
2.3.1 DC Methods......Page 152
2.3.2 Impedance Spectroscopic Interface Characterization: Titanium in Contact with Electrolyte and Biosystem......Page 156
References......Page 163
3.1 Electronic Structure of the Interface......Page 166
3.2 Spectro-electrochemistry of the Surface......Page 171
References......Page 175
4 Physical Characterization of Protein Adsorption: Time-Resolved Determination of Protein Adsorption Using Quartz Crystal Microgravimetry with Dissipation Monitoring (QCM-D)......Page 176
References......Page 184
5 Computer Simulations: Modeling of Protein Adsorption on Nanostructured Metallic Surfaces......Page 186
References......Page 191
III Biological Characterization of the Interface and Materials-Related Biosystem Reactions......Page 194
1.1 Characterization of Surface-Dependent Protein Adsorption......Page 196
1.2.1 Hyaluronan-Mediated Adhesion......Page 202
1.2.2 Integrin-Mediated Adhesion on Nanostructures......Page 205
1.3 Surface Structure-Dependent Protein Expression in Adsorbed Cells......Page 207
References......Page 210
2.1.1 Influence of the Material Interface on Cell Migration......Page 214
2.1.2 Titanium–Cell Interface: Cell Biology and Growth Behavior......Page 219
2.2 Endothelial Cell-Specific Aspects in Biocompatibility Testing In Vitro......Page 227
References......Page 234
3.1 Cell Structure–Cell Function Dependence on Titanium Surfaces......Page 238
3.2.1 Cell Biological Response on Polished, Structured and Functionally Coated Titanium Alloys......Page 246
3.2.2 Effect of Nanostructures on Orientation and Physiology of Osteoblasts......Page 256
3.2.3 Cell Response to Ti6Al4V Modified with TiO(2) and RGDS Peptides on Different Surface Roughness......Page 260
3.2.4 Endothelial Cell Morphology on Functionalized Microstructured Titanium......Page 262
3.3 Resistivity of Cells Under Shear Load......Page 265
References......Page 268
Index......Page 272