Metabolic Compartmentation and Neurotransmission: Relation to Brain Structure and Function

Front Matter....Pages i-xxiii
Glutamic Acid, a Putative Neurotransmitter of Cerebellar Granule Cells: Evidence from the Virally Induced Granuloprival Cerebellum....Pages 1-10
Gamma-Aminobutyric and Glutamic Acids as Mammalian Central Transmitters....Pages 11-36
Neurochemical Evidence for Glycine as a Transmitter and a Model for Its Intrasynaptosomal Compartmentation....Pages 37-63
Uptake and Localization of Transmitter Amino Acids in the Nervous System....Pages 65-89
Glial Transport of Amino Acid Neurotransmitter Candidates....Pages 91-97
The Localization of Glutamate Decarboxylase, Choline Acetyltransferase, and Aromatic Amino Acid Decarboxylase in Mammalian and Invertebrate Nervous Tissue....Pages 99-122
Uptake of Transmitter Candidates as an Approach to their Localization....Pages 123-135
The Olfactory Pathway as a Model Cerebral System....Pages 137-143
Techniques for Separation of Neurons and Glia and Their Application to Metabolic Studies....Pages 145-166
Compartmentation of Striatal Dopamine: Problems in Assessing the Dynamics of Functional and Storage Pools of Transmitters....Pages 167-186
Regulation of Synthesis and Release Processes in Central Catecholaminergic Neurons....Pages 187-203
Cyclic AMP and Protein Phosphorylation in the Central Nervous System in Relation to Synaptic Function....Pages 205-228
Ortho- and Retrograde Trophic Effects on Adrenergic Neurons: Regulation of Enzyme Synthesis by the Activity of Preganglionic Fibers and Retrograde Axonal Transport of Nerve Growth Factor....Pages 229-245
Contractile Proteins in Relation to Transmitter Release....Pages 247-271
Physiology of CNS Tissues in Culture....Pages 273-303
The Culture of Established Clones for Neurobiologic Investigation....Pages 305-326
Introduction to Simulation Techniques in Neurochemistry....Pages 327-336
Metabolic Compartmentation in the Brain and Effects of Metabolic Inhibitors....Pages 337-361
Factors Affecting the Development of Metabolic Compartmentation in the Brain....Pages 363-383
Effect of 1-Hydroxy-3-aminopyrrolidone-2 and Other CNS Depressants on Metabolic Compartmentation in the Brain....Pages 385-395
Biochemical Dissection of the Cerebellum—Introduction....Pages 397-402
Biochemical Dissection of the Cerebellum—Subcellular Fractionation of Rat Cerebellum. Electron Microscopy: A Guide and Safeguard....Pages 403-415
Biochemical Dissection of the Cerebellum— Enzyme Composition of Subcellular Fractions, Including Complex Structures Derived from the Cerebellar Glomeruli....Pages 417-426
Biochemical Dissection of the Cerebellum—Functional Properties of the “Glomerulus Particles”....Pages 427-436
Biochemical Dissection of the Cerebellum—Isolation of Perikarya from the Cerebellum with Well-Preserved Ultrastructure....Pages 437-448
Ethanol and Its Relation to Amino Acid Metabolism in Brain....Pages 449-460
An Experimental Model of CNS Changes Associated with Chronic Liver Disease: Portocaval Anastomosis in the Rat....Pages 461-478
Further Support for the Subdivision of the Small Metabolic Compartment: Effect of Halothane....Pages 479-485
Compartmentation of Citric Acid Cycle and Related Enzymes in Distinct Populations of Rat Brain Mitochondria....Pages 487-496
Relationship between Amino Acid and Catecholamine Metabolism in Brain....Pages 497-513
A Model of Glutamate Metabolism in Brain: A Biochemical Analysis of a Heterogeneous Structure....Pages 515-543
Glucose and Ketone-Body Utilization in Young Rat Brains: A Compartmental Analysis of Isotopic Data....Pages 545-558
Transmethylation and Transsulfuration Enzymes in Rat Brains: Their Subcellular Distribution....Pages 559-565
Some Processes Involved in Regulating the Function of Brain 5-Hydroxytryptamine....Pages 567-576
The Kinetics of 5-Hydroxyindoleacetic Acid Excretion from Rat Brain and CSF: Preliminary Studies and Multicompartment Analysis....Pages 577-584
Synthesis and Storage of Acetylcholine in Cholinergic Nerve Terminals....Pages 585-607
The Origin and Some Possible Mechanisms of the Release of Acetylcholine at Synapses....Pages 609-619
Dynamics of Acetylcholine Compartments at Rest and During Nerve Activity....Pages 621-639
Preferential Release of Newly Synthesized Acetylcholine by Cortex Slices from Rat Brain....Pages 641-649
Maturation and Aging of Vertebrate Neurons....Pages 651-682
Back Matter....Pages 683-721