Mesenchymal Stem Cells in Human Health and Diseases

Cover
Mesenchymal Stem Cells in Human Health and Diseases
Copyright
Dedication
How To Use
Contributors
About the editor
Foreword by Alexzander A.A. Asea
Foreword by Junfeng Ji
Preface
Acknowledgments
1 - Mesenchymal stem cells in regenerative medicine and diseases: hope for better human health
	References
	Further reading
2 - Application of mesenchymal stem cells in human diseases
	Introduction: background and driving forces
	History of mesenchymal stem cells
	Function of mesenchymal stem cells
		Mesenchymal stem cells as seed cells participate in tissue regeneration
			Mesenchymal stem cells for myocardial injury
			Mesenchymal stem cells for osteoarthritis, lower back pain, and cartilage repair
			Mesenchymal stem cells for pulmonary disease
			Mesenchymal stem cells for liver disease
			Mesenchymal stem cells for gastrointestinal disease
		Mesenchymal stem cells as modulators participate in tissue homeostasis and regeneration
	Controversy over and expectations for mesenchymal stem cells
	Conclusion
	References
3 - Immunoregulatory properties of mesenchymal stem cells and their application in immunotherapy
	Immunomodulatory effects of mesenchymal stem cells
	Mechanisms of antiinflammatory effects of mesenchymal stem cells
	Prospective and concluding remarks
	References
4 - Stem cell therapies in ocular repair, regeneration, and diseases
	Introduction
	Stem cell therapy for retinal diseases
	Stem cell therapy for corneal diseases
	Corneal stem cell types
	Corneal and limbal stem cell markers
		Regulatory factors of limbal stem cell proliferation
	Stem cell therapeutic approaches for corneal diseases
	Limbal stem cell deficiency
		The management of patients with limbal stem cell deficiency
			Conjunctival limbal autografts
			Living related conjunctival limbal allograft
			Cadaveric keratolimbal allografts
			Simple limbal epithelial transplantation
	Ex vivo expansion limbal stem cell transplantation
		Cultivated oral mucosal epithelial transplantation
	Conclusions, challenges and future directions
	References
	Further reading
5 - Applications of the stem cell secretome in regenerative medicine
	Introduction
		The potential of stem cells in regenerative medicine
		The concept of the secretome
	Modulation of the stem cell secretome profile
		Three-dimensional cultures and biomaterials
		Preconditioning of stem cells
		Bioreactors
	Application of the stem cell secretome in CNS disorders
		Stroke
		Traumatic brain injury
		Parkinson disease
		Spinal cord injury
	Concluding remarks
	References
6 - Innovation in induced mesenchymal stem cell uses in therapy
	Introduction
	Major sources of induced mesenchymal stromal/stem cells
	Induced mesenchymal stromal/stem cell applications in cell therapy
	Conclusion
	References
7 - Role of mesenchymal stem cells in bone fracture repair and regeneration
	Introduction
	Sources of mesenchymal stem cells for bone regeneration
	Mesenchymal stem cell homing in bone regeneration
	Molecular mechanisms affecting mesenchymal stem cell homing
	External factors affecting mesenchymal stem cell homing
	The application of mesenchymal stem cells in bone tissue regeneration
		Immunogenicity of mesenchymal stem cells
		The isolation and treatment approach of mesenchymal stem cells
		Genetically modified mesenchymal stem cells for bone regeneration
		Application of biological materials and growth factors in mesenchymal stem cell bone repair
	Clinical consequences
	Conclusion
	References
8 - Tendon stem cells and their interaction with microenvironments
	Introduction
	Isolation and culture of tendon stem/progenitor cells
	Characterization of tendon stem/progenitor cells
	Culture conditions
	Cell passage and senescence
	Growth factors
	Mechanical stimulation
	Extracellular matrix and scaffold
	Clinical relevance: the role of tendon stem/progenitor cells in tendon disease
	Conclusion and forecast
	Acknowledgments
	References
9 - Mesenchymal stem cell roles in osteoarthritis (joint) disease
	Conclusion
	References
	Further reading
10 - Mesenchymal stem cells and cancer therapy
	Introduction
	The application of mesenchymal stem cells in cancer treatments
	Limiting factors of the mesenchymal stem cell–mediated cancer therapies
	Conclusions and future directions
	References
11 - Mesenchymal stem cells in human health and diseases: general discussion, remarks, and future directions
	References
Index
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