Meeting the Challenges of Blood Safety in the 21st Century: Pathogen Inactivation

Contents......Page 3
References......Page 4
Introduction......Page 5
Transfusion of Pathogens......Page 6
Bacterial Contamination......Page 7
Viral Pathogens......Page 8
Transfusion of Residual Leukocytes......Page 10
Summary......Page 11
References......Page 12
Historical Perspective on Psoralens......Page 14
Sequence Specificity......Page 15
Adduct Frequency in the Actual PCT Process......Page 16
Effect of Inactivation on NAT......Page 17
References......Page 18
Introduction......Page 20
What Has Been Tested and Why?......Page 21
Safety Pharmacology and Acute Toxicity Studies......Page 22
Carcinogenicity Test......Page 23
Risk Assessment of Platelets Treated with the INTERCEPT Blood System......Page 24
Acknowledgement......Page 25
References......Page 26
Incidence......Page 27
Clinical Manifestation......Page 28
Gamma-Irradiation of Blood Components......Page 29
Dose of Gamma-Irradiation,Equipment,and Dosimetry......Page 30
Pathogen Inactivation as an Alternative to Gamma-Irradiation......Page 31
Conclusion......Page 32
References......Page 33
Background......Page 35
Residual Plasma in Platelet Concentrates......Page 36
Data Management and Quality Assurance......Page 37
Conclusion......Page 38
References......Page 39