Medical bioinformatics and biochemistry (diabormatics)

Medical Bioinformatics  and Biochemistry
(Diabormatics)
Medical Bioinformatics  and Biochemistry
(Diabormatics)
Contents
Preface
Chapter 1
Diabetes and Diabormatics:  An Introduction
	Abstract
	Introduction
	1.1. Diabetes: An Introduction
	1.2. Role of Insulin and Glucagon in Regulating Blood Glucose Level
	1.3. Medications for Diabetes
	Conclusion
	References
Chapter 2
Combined Effect of Vitamin C and E Dose on Type 2 Diabetes Patients
	Abstract
	Introduction
	2.1. Use of Vitamin C and E  for Diabetes Treatment
	Conclusion
	References
Chapter 3
In-Silico Structure Modelling  and Docking Studies Using Dipeptidyl Peptidase-4 (DPP4) Inhibitors against Diabetes Type-2
	Abstract
	3. Introduction
	3.1. Methodology
		3.1.1. Sequences Retrieval and Alignment
		3.1.2. Molecular Modelling of DPP4
		3.1.3. Docking of DPP4 (NP_001926) with SKK
	3.2. Results and Discussion
		3.2.1. Building of Protein Model
		3.2.2. Model Reputation
		3.2.3. Model Validation
	Conclusion
	References
Chapter 4
Homology Modelling and Structural Validation of Type 2 Diabetes Associated Transcription Factor  7-Like 2 (TCF7L2)
	Abstract
	Introduction
	4.1. Methodology
		4.1.1. Operating System
		4.1.2. Sequence Retrieval, Alignment and Homology Modelling
		4.1.3. Model Reputation
	4.2. Results
		4.2.1. Building of Protein Model
		4.2.2. Model Reputation
		4.2.3. Model Validation
	Conclusion
	References
Chapter 5
Effect of Vitamin E and C Supplementation on Oxidative Stress in Diabetic Patients
	Abstract
	Introduction
	5.1. Methodology
	5.2. Results and Discussion
	Conclusion
	References
Chapter 6
In Silico Structure Analysis of Type 2 Diabetes Associated Cysteine Protease Calpain-10 (CAPN10)
	Abstract
	Introduction
	6.1. Methodology
		6.1.1. Operating System
		6.1.2. Retrieval of Sequences and Sequence Alignment
		6.1.3. Molecular Modelling of Calpain10
	6.2. Results and Discussion
		6.2.1. Building of Protein Model
		6.2.2. Model Reputation
		6.2.3. Model Validation
	Conclusion
	References
Chapter 7
To Evaluate the Role of Leptin in Diabetes for Male  and Female Subjects
	Abstract
	Introduction
	7.1. Methodology
	7.2. Results
	Conclusion
	References
Chapter 8
Study of Leptin and Adiponectin  in Type 2 Diabetes Mellitus
	Abstract
	Introduction
	8.1. Materials and Methods
	8.2. Results
	Conclusion
	References
Chapter 9
Study on Correlation  of Inflammatory Markers  on Type-II Diabetes
	Abstract
	Introduction
	9.1. Uric Acid as an Inflammatory Marker in Diabetes Mellitus
	9.2. CRP as an Inflammatory Marker in Diabetes Mellitus
	9.3. Methods
		9.3.1. Sample Size and Sampling method
	Conclusion
	References
Chapter 10
Nano-Diabetology
	Abstract
	Introduction
	10.1. Detection of Insulin and Blood Sugar
		10.1.1. By Micro-Physiometer
		10.1.2. By Implantable Sensor
	10.2. Methodology
		10.2.1. Conventional
		10.2.2. Microsphere
		10.2.3. Nano-Pump
		10.2.4. Artificial Pancreas
	10.3. Role of Nano Technology  in Glucose Monitoring
		10.3.1. Glucose Nanosensors
		10.3.2. Layer-by-Layer (LBL) Technique
		10.3.3. Carbon Nanotubes
		10.3.4. Quantum Dots (QDs)
	10.4. Development of Patient-Friendly Insulin Delivery Nanoparticle Formulations
		10.4.1. Anti-Oxidative Role of Nanoparticles
	10.5. Applications of Nanomedicine  in Health Care and Disease
	Conclusion
	References
Chapter 11
Effect of Ajowan Seed Powder on Oxidative Stress in Normal  and Niddm Patients
	Abstract
	Introduction
	11.1. Methodology
		11.1.1. Statistical Analysis
	11.2. Results
	Conclusion
	References
About the Editors
Index
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