Mechanisms of Epileptogenesis: The Transition to Seizure

Front Matter....Pages i-x
Brain Metabolism and Pathophysiology of Human Epilepsy....Pages 1-15
Electrophysiology of the Interictal-Ictal Transition in Humans....Pages 17-38
Initiation and Spread of Seizures in Man: Analytical Methods for Monitoring Seizures....Pages 39-56
Cellular Mechanisms of Interictal-Ictal Transitions....Pages 57-71
Primary Generalized Seizures with Spike and Wave Discharge....Pages 73-83
Mechanisms of Kindling: A Speculative Hypothesis....Pages 85-99
Some Subcortical Mechanisms Involved in Experimental Generalized Seizures....Pages 101-110
Anatomical and Neurochemical Substrates of Clonic and Tonic Seizures....Pages 111-152
Frequency Dependent Changes in Excitatory Synaptic Efficacy....Pages 153-167
Modulation of Inhibition and the Transition to Seizures....Pages 169-181
Nonsynaptic Mechanisms and Interictal-Ictal Transitions in the Mammalian Hippocampus....Pages 183-198
Coupling of Energy Metabolism and Ictal Transformation....Pages 199-203
NMR Studies of Metabolism in Experimental Models....Pages 205-220
Mechanisms of Anticonvulsant Action....Pages 221-238
New and Old Antiepileptic Drugs....Pages 239-254
Tactical Considerations Leading to Surgical Treatment of the Partial Epilepsies....Pages 255-279
Back Matter....Pages 281-287